首发抑郁症患者海马容积的研究

目的探讨首发抑郁症患者海马容积的特点。方法采用磁共振成像(MRI)技术检测19例首发抑郁症患者和19例正常对照的海马容积。结果治疗前病例组的双侧海马绝对容积(AHV)以及相对容积(AHV/ICV)均低于正常对照组,差异有统计学意义(P<0.05);病例组海马绝对容积(AHV)与病程高度相关。病例组治疗后双侧海马绝对容积(AHV)及相对容积(AHV/ICV)较治疗前增加,且差异有统计学意义(P<0.05)。结论首发抑郁症患者海马容积变化在疾病的发病与转归过程中起着重要的作用。     

浅谈做好建设施工项目的成本控制的分析

从建筑工程项目成本控制涉及工程项目的各个环节入手,通过对成本计划和影响项目成本的主要因素的分析,重点阐述了成本控制应遵循的主要原则和措施,从而提高企业的成本管理水平。     

电控发动机重型车辆装配线终端检测系统的开发

通过对电控发动机重型车辆装配线终端检测系统软件架构和硬件架构分析,介绍该系统的设计和开发方法及系统具有的功能。阐述对于类似系统应该如何选择稳定可靠的硬件及该使用何种软件进行开发。     

公路桥梁震害分析及对策

地震会造成大量桥梁结构的破损,严重影响道路运输的正常运营。采取何种措施降低桥梁震害已成为桥梁工程的热点问题。从桥梁震害破坏形态上将桥梁震害的破坏分为上部结构破坏和下部结构破坏,重点分析了梁体偏移和落梁、支座破坏、伸缩缝和挡块破坏、墩台和基础破坏的现象及成因。结合调查分析,在桥位选择、抗震设计理念以及结构和构造等方面给出桥梁抗震的对策和建议,为桥梁设计、施工提供借鉴和参考。     

灰土挤密桩在辽西湿陷性黄土路基处治中的试验研究

本文对湿陷性黄土路基处治试验路段施工进行总结,对灰土挤密桩处治后的路基进行现场试验和效果分析,掌握了灰土挤密桩的施工工艺及检验方法。     

音乐事件θ波相关分析

通过音乐事件影响不同性别人群情绪变化,对EEG数据中的θ波进行相关计算和分析,得出音乐情绪不仅与θ波有着密切的关系,而且对左右脑半球神经皮质活动的同步性有重大影响.在安静闭眼放松时,女性的同步性高于男性.无论是听喜欢的还是不喜欢的音乐,前额、头顶和顶枕部的同步性高于侧头部.此外,也给出了脑不同部位对音乐事件相关性变化的规律,并得出头顶和顶枕部对区别男女情绪变化有重要作用.     

音乐事件θ波相关分析

通过音乐事件影响不同性别人群情绪变化,对EEG数据中的θ波进行相关计算和分析,得出音乐情绪不仅与θ波有着密切的关系,而且对左右脑半球神经皮质活动的同步性有重大影响.在安静闭眼放松时,女性的同步性高于男性.无论是听喜欢的还是不喜欢的音乐,前额、头顶和顶枕部的同步性高于侧头部.此外,也给出了脑不同部位对音乐事件相关性变化的规律,并得出头顶和顶枕部对区别男女情绪变化有重要作用.     

客流高峰期铁路客运组织策略探讨

客流高峰期需要对铁路运输能力进行重新分配、调整和加强.通过分析、总结高峰期客流的构成成分以及特性,比较客流高峰期与日常旅客运输组织的差异,从合理组织开行临时旅客列车、加强旅客售票组织,以及加强车站内部组织管理三方面来探讨客流高峰期旅客运输组织问题,为如何快速、有效地满足高峰期客流的出行需求、减轻高峰期铁路运输压力提供参考.     

Induction of animal model of Graves' disease in BALB/c mice

Objective To construct an animal model of Graves' disease (GD) by immunizing BALB/c mice with hM12 cells co-expressing major histocompatibility complex (MHC) class Ⅱ molecules and human thyrotropin receptor (TSHR) molecules. Methods BALB/c mice in experimental group (H-2d) were immunized with hM12 cells Intraper-itoncally every 2 weeks for six times, while mice in control group were immunized with M12 cells. Five weeks later, the thyroids were histologically examined, and serum samples were tested for thyroid-stimulating antibodies (TSAb) and thyroid hormone levels. Results One BALB/c mouse in experimental group developed Graves'-like disease. Total T4 and T3 levels in this mouse were above the upper limit of normal, TSAb activity was displayed in its serum. The thyroid histologically showed the features of thyroid hyperactivity including thyrocyte hypercellularity and colloid absorption.None of control mice developed Graves'-like disease. Conclusion An animal model with some characteristics of human Graves' disease was successfully induced and the model will facilitate studies aimed directly at understanding the patho-genesis of autoimmunity in Graves' disease.     

Effects of PYY on the interdigestive migrating myoelectric complex in the small intestine in vivo and the neural and endocrinal mechanisms of the effects

Objective To investigate the effects of peptide YY (PYY) on the interdigestive migrating myoelectrlc complex (MMC) in the small intestine in vivo and explore the neural and endecrinal mechanisms of the effects. Methods Spragne-Dawley rats were supplied with a venous catheter and bipolar electrodes in the duodenum and jejunum for electromyography of stomach and small intestine in wake state. PYY, phentolamine, nitro-L-arginine (L-NNA, the inhibitor of nitric oxide synthase) and atropine were served with PYY respectively. The plasma motilin levels before and after the infusion of PYY were observed. Results At all the three recording points, PYY lengthened the drde length of MMC [from (591.90±128.98)s to (999.25±216.59)s, P<0. 01] and lowered the frequency of phase Ⅲ [from (39.28±8.40) min-1 to (22.08±3.13) min-1 , P<0.01], amplitude of phase Ⅲ [from (0. 320±0.060)mV to (0. 179±0.030)mV, P<0.01], and the portion of phase Ⅲ over the whole circle length [from (28. 61 ± 5.84)% to (15.43 ±5.16)% , P<0.01]. Phentolumine had no influence on the role of PYY. Administered L-NNA combined with PYY, the percentage of phase Ⅲ increased [(42. 09±8.67)%] compared with that of control(P<0.01) and compared with that of PYY administered alone (P<0. 01) too. Atropine combined with PYY showed stronger depressing effects on MMC. No significant difference was found between the plasma motilin levels before and after the infusion of PYY. Conclusion PYY my inhibit the interdigestive intestine motility through the none-adrenergic none-choUnergic tract, while the m-receptor tract and circulating motilin are probably not involved In the depressing effect.