Role of candesartan against cerebral ischemia and oxidative damage in normotensive rats

Objective Angiotensin Ⅱ (Ang Ⅱ ) contributes to modulating blood pressure by stimulation of Ang Ⅱ AT1 receptors. We devised a rat transient middle cerebral artery occlusion (MCAO) model to assess whether oxidative damage is decreased after pretreatment with Angiotensin Ⅱ AT1 receptor blocker (ARB). Methods After 2 weeks pretreatment with ARB 0. 5 and 1 mg/kg, the male Wister rats were subjected to 2 h middle cerebral artery occlusion (MCAO). At 24 h, the lumen diameter of middle cerebral artery, the plasma level of 8-hydroxy-2'-deoxyguanosine (8-OHdG), and HIF-1 a levels were recorded and compared. Results After pretrcatment with ARB 0.5 and 1 mg/kg, blood pressure did not significantly change compared with that of controls. In the group of candesartan at 1 mg/(kg· day), the lumen diameter was significantly increased compared to that in control group [(86.0±5.0) μm vs. (69.0± 2.1) μm; P<0. 01, n = 6- 8]. The plasma 8-OHdG levels of ARB pretreatment groups were decreased. In immunohistochemical findings, 8-OHdG- and HIF-1α-containing cells in ARB pretreatment groups were decreased. Conclusion Brain ischemia and oxidative damage can be reversed by AT1 receptor blockade in normotensive rats after transient cerebral artery occlusion.     

高速公路中收费和清分的动态解决方案

在高速公路收费和清分过程中,由于新增的高速公路和收费站点特别是环型路段的增加使得原有的静态算法已经不适宜于现实情况。本文提出了高速公路中基于最短路径和环型路段的动态收费和清分解决方案,并给出了详细的基于环型路段的动态算法。环型路段问题解决后,可以判知车辆实际行车路线,从而大幅提高收费及清分的准确性和效率。     

辽宁滨海公路潮差侵蚀路段路基顶面标高的推算方法

结合辽宁省滨海公路填海路基的实际情况,分析了确定受潮差影响路段路基顶面标高的主要影响因素,提出了滨海公路路基顶面标高的推算方法,并结合实际工程给出应用案例.     

Modeling Feedback Scheme of Empty Cars in Unloading End of Heavy Haul Railway

The transportation organization of heavy haul railway is complex in China, especially, the feedback of empty cars. On the basis of reference to the existing research results, and deep analysis of the characteristics of empty cars distribution of heavy haul railway, the authors construct the feedback schematic model of empty cars in unloading end of heavy haul railway. The minimum quantity of the combined trains and the time for combination is taken as the model goal and solution algorithm on the basis of minimum cost and maximum flow is formulated. Daqin railway is taken as an example and relevant conclusions of feedback scheme of empty cars of heavy haul railway, through an analysis of calculation results, are drawn.     

甲状腺癌组织端粒酶逆转录酶和P53基因表达及其临床意义

目的　探讨端粒酶逆转录酶 (hTERT)和P5 3基因与甲状腺癌的发生、发展及预后的关系以及它们的相互关系。方法　应用免疫组织化学SP法检测 6 0例甲状腺癌、10例正常甲状腺组织、10例结节性甲状腺肿及 10例甲状腺腺瘤组织中hTERT和P5 3的表达。结果　hTERT和P5 3阳性率在甲状腺癌中增高 (P <0 .0 5 ) ;hTERT与P5 3阳性率在未分化癌、有淋巴结转移或Ⅲ、Ⅳ期病例中增高 (P <0 .0 5 ) ;hTERT表达与P5 3表达具有相关性 (P <0 .0 5 )。结论　hTERT与P5 3的过度表达在甲状腺癌的发生发展过程中具有重要作用 ,P5 3突变在转录水平上调控hTERT基因的表达 ,激活端粒酶可能是甲状腺癌发生发展的重要阶段 ;hTERT和P5 3在甲状腺癌中表达的变化可用于评估其生物学行为和判断预后。     

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以主枢纽城市交通信息港的建设为背景，从共用信息平台建设中的网络方案、平台的总体构架、平台的实现和平台安全四个平台建设的主要方面提出交通信息港中共用信息平台的建设方案;从而能够在交通信息网络互联，共同提供信息的前提下，保证交通信息资源的全方位、多角度的共享，真正体现交通信息互连和共享的信息化特征.     

CACC车辆跟驰建模及混合交通流分析

建立协同自适应巡航控制(Cooperative Adaptive Cruise Control,CACC)车辆跟驰模型,并分析不同CACC比例下的混合交通流通行能力,尾部碰撞安全及交通排放.考虑车辆期望车头间距随速度动态变化的交通流特性,建立基于非线性动态车头间距策略的CACC跟驰模型,推导不同CACC比例下的混合交通流基本图模型,分析CACC提高通行能力的交通流运行机理.设计高速公路上匝道瓶颈数值仿真实验,评估不同CACC比例下的车辆尾部碰撞安全隐患,以及油耗、CO、HC、NOx的排放.研究结果表明,本文建立的CACC模型能够在交通流速度基本不变的情况下,以较高的交通流密度显著提升通行能力,同时有利于车辆尾部碰撞安全风险及交通排放的降低.     

Decomposing and Cluster Refinement Design Method for Application-Specific Network-on-Chips

Along with higher and higher integration of intellectual properties (IPs) on a single chip, traditional bus-based system-on-chips (SoC) meets several design difficulties (such as low scalability, high power consumption, packet latency and clock tree problem). As a promising solution, network-on-chips (NoC) has been proposed and widely studied. In this work, a novel algorithm for NoC topology synthesis, which is decomposing and cluster refinement (DCR) algorithm, has been proposed to minimize the total power consumption of application-specific NoC. This algorithm is composed of two stages: decomposing with cluster generation, and cluster refinement. For partitioning and cluster generation, an initial low-power solution for NoC topology is generated. For cluster refinement, the clustering is optimized by performing floorplan to further reduce power consumption. Meanwhile, a good tradeoff between power consumption and CPU time can be achieved. Experimental results show that the proposed method outperforms the existing work.     

长江经济带战略背景下长江上游港口群发展

水运是长江上游省份进出口贸易和地区间物资运输的重要方式。首先,论述了长江上游内河航运地位的变迁和未来发展态势。改革开放以后长江作为东西向物流运输大通道的功能逐渐发挥,未来上游地区的江海联运仍然具有明显优势。其次,探讨了长江上游港口群的发展历史、发展态势及亟须协调的问题。主要港口由单一商贸功能向商贸加生产的综合功能转变,并通过多式联运积极拓展腹地,但港口生产能力过剩,且核心港区功能还有待加强。最后,对长江经济带战略背景下长江上游内河航运和港口群的发展提出建议,指出要加快形成港口群合力,建设重庆长江上游航运中心,完善核心港区功能。     

考虑排放约束的电动汽车混行交通路网均衡模型

随着电动汽车的推广和使用,电动汽车与燃油汽车在路网中交互运行,形成了混行交通环境.本文构建考虑排放约束和途中充电的电动汽车混行交通路网均衡模型.首先,分别定义了电动汽车用户与燃油汽车用户的出行成本函数,其中电动汽车用户出行成本包含行驶时间、充电排队时间及充电时长.其次,构建了考虑排放约束的混行交通路网均衡模型,证明了解的唯一性,推导了模型对应的KKT条件,且与Wardrop第一原理等价.然后,将均衡模型表述为包括用户均衡条件、排放约束、守恒约束的互补性条件形式,通过引入间隙函数,进一步将其转化为等价的无约束最优化问题,并利用基于梯度的算法进行求解.最后,通过算例验证了均衡模型及算法的有效性,结果表明:(1)考虑路网排放约束将影响混行交通量和充电站充电流量空间分布;(2)总需求和电动汽车渗透率不变的条件下,提高减排力度会导致路网总行程时间的增加;(3)给定减排力度时,可以确定路网总行程时间最小时对应的电动汽车最优渗透率.