Effects of erigeron breviscapus （Vant.） Hand-Mazz pretreatment on pathology and oxyradical level following spinal cord ischemia-reperfusion injury in rabbits

Objective To investigate the effects of erigeron breviscapus (Vant.) Hand-Mazz (erigeron breviscapus) pretreatment on pathology and oxyradical level in the spinal cord after ischemia-reperfusion (I/R) injury in rabbits. Methods A total of 40 New Zealand white rabbits were randomly divided into three groups: sham-operation group with 10 rabbits treated with only abdominal aorta exposure without occlusion, control group with 15 rabbits that underwent ischemia for 50 minutes and treated with matched saline, and experimental group with 15 rabbits that underwent ischemia for 50 minutes and treated with erigeron breviscapus (9mg/kg) injection before ischemia. Malondialdehyde (MDA) level and superoxide dismutase (SOD) activity in the spinal cord were examined at 6 and 24 hours after I/R, respectively. The morphological changes and the number of the spinal cord anterior horn motor neurons were observed and counted under the light microscope and electron microscope, respectively. Results The level of MDA was markedly decreased and SOD activity was increased in the experimental group compared with those in the control group (P<0.01). Compared with that in the control group, the number of motor neurons in the experimental group significantly increased at 24h after I/R (P<0.01) and the morphous of the motor neurons improved. Conclusion Erigeron breviscapus can reduce oxyradical production and the apoptosis of nerve cells, and protect nerve tissue structure and function after spinal cord I/R.     

高速公路施工区交通组织方案研究

首先分析了高速公路施工区交通组织的基本原则,提出施工作业区长度控制问题,并提出了施工区各控制区（警告区、锥形区和缓冲区）的长度标准,深入研究了施工区的限速分级标准和程序,通过推荐新增施工区的各类标志,与现有的施工区交通标志共同构成了施工区的标志系统,在此基础上,对高速公路施工区交通标志和交通安全设施的设置进行了研究。     

一种避免航迹聚集的改进的JPDA方法

提出了使用分类信息来改进传统的JPDA方法,在数据关联过程中综合使用了目标的运动学信息和目标的分类信息,提高了在跟踪波门内目标正确关联的概率,有效避免了航迹聚集现象.理论分析和仿真结果表明,尤其当多个临近目标的属性信息差别明显时,有目标分类信息辅助的JPDA方法可以显著提高跟踪波门内目标的正确关联概率,降低波门内其他目标/杂波的关联概率,使得被跟踪目标的信息更新以正确目标的信息为主.仿真结果验证了算法的正确性和有效性.     

Protective effect of glutamine pretreatment on ischemia-reperfusion injury of spinal cord in rabbits

Objective To investigate the effect of glutamine (Gln) on the content of reduced glutathione hormone (GSH) and aminoglutaminic acid (Glu) of spinal cord following ischemia-reperfusion injury. Methods Totally 40 healthy adult male rabbits were randomly divided into five groups: sham-operation group (S group), ischemia-reperfusion injury group (I/R group), low-dose glutamine group (L Gln group), median-dose glutamine group (M Gln group) and high-dose glutamine group (H Gln group). After glutamine preconditioning, the model of spinal cord ischemia-reporfasion injury was established according to Zivin's method. The general status of animals was observed and the changes of Jacobs scoring were recorded in each group. Malondialdehydes (MDA), GSH, Glu and superoxide dismutase (SOD) activity in lumbar spinal cord tissues were determined using chemical colorimetry. The neuron number and deviation rate in spinal cord anterior horn were observed histopathologically. Results There was no significant difference between L Gin group and I/R group in behavior scoring, SOD activity, content of MDA and Glu, neuron number and deviation rate of spinal cord (P>0.05); however, there was a significant difference in GSH content of spinal cord (P<0.05). M Gln group and I/R group differed significantly (P<0.05) in behavior scoring, SOD activity, content of MDA, Glu, GSH, neuron number and deviation rate of spinal cord. Between H Gln group and M Gln group, there was no significant difference in behavior scoring, content of MDA and Glu, SOD activity, neuron number and aberration rate in spinal cord (P>0.05), whereas there was a significant difference in SOD activity and Giu content (P<0.05). Conclusion Pretreatment with medium-dose glutamine has a protective effect on spinal cord ischemia-reporfasion injury in rabbits, which may be related to the maintenance of GSH content, increase of SOD activity and reduction of MDA.     

不确定语言环境下危险品公路运输路径决策模型

在危险品运输路径选择过程中,由于客观事物的复杂性,部分已知信息往往是不确定的,这给选择最优路径带来了很大的困难.文中先利用不确定的扩展加权算术平均算子对评估矩阵中的不确定语言评估信息进行集结, 然后利用不确定语言混合集结算子对全体决策者给出的决策方案综合属性评估值进行集结,进而利用可能度矩阵确定最优的运输路径,最后用算例验证了方法的可行性.     

基于减法聚类模糊神经网络高速公路混沌控制

研究了基于减法聚类的高速公路混沌系统模糊神经网络控制方法.提出通过数据挖掘技术建立交通流混沌控制器知识库的思想,设计了以密度、上游流量和最大李亚普诺夫指数作为输入,红灯时间作为输出的T-S模糊神经网络混沌控制器.采用减法聚类确定控制器结构提取模糊规则、控制器初始参数;应用模糊神经网络方法对控制器参数进行优化;结合遗传算法对聚类半径进行优化.仿真实验分析了该控制方法的控制效果,证明了该混沌控制方法的有效性.     

保障基本机动性的中央财政公交投入机理

中央财政公交投入不到位是中国城市公交优先发展面临的重要问题,加强中央财政资金投入、完善公交财政保障体系才能确保未来城市公交发展的可持续动力。提出保障公民基本机动性平等是中央政府支持城市公交发展的重要价值基准,从法理上为中央财政承担城市公交支出责任提供依据。从基本公共服务供给最低水平均等化的角度出发,提出中央财政公交投入资金额度的测算方法,为中央财政公交投入的科学决策提供了参考依据。以2010年为目标年进行案例分析,测算得到全国保障基本机动性的中央财政公交投入总额为150.1亿元。     

基于三阶段最小二乘法探究诱增交通量

在诱增交通量的预测中,中国现有统计数据在精度和广度上的局限性,容易造成计算结果存在遗漏变量偏误和测量误差偏误;同时变量之间的相关性容易导致计算结果存在联立性问题。为克服这些问题,采用工具变量法中的三阶段最小二乘法探讨道路供给与交通需求之间的关系。基于国家统计数据库数据,选择车辆出行距离、民用汽车拥有量和交通拥堵水平三个内生变量构建联立方程模型,采用三阶段最小二乘法对联立方程进行估计,并给出短期、长期弹性系数的求解方法。结果表明,道路建设会导致车辆出行距离增加,不能解决中国城市交通拥堵问题,而大力发展公共交通可以降低交通拥堵水平。     

水稳沥青路面冷再生基层材料路用性能研究

水泥稳定冷再生基层材料的路用性能对路面结构有着重要影响,对原路面和基层回收材料进行分析,用掺入不同水泥和新骨料的冷再生基层材料,对处于不同面及基层厚度比的材料进行路用性能试验。通过无侧限抗压强度、劈裂强度、抗压回弹模量以及抗冻性的实验研究,并结合路面弯沉值进行分析,研究结果表明水泥稳定就地冷再生基层材料具有良好的路用性能。     

膨胀岩土地层修建盾构隧道引起的局部膨胀荷载研究

从理论上推导了岩土局部膨胀引起的附加膨胀荷载计算公式;结合数值分析方法,研究了不同位置、不同范围发生地层局部膨胀对衬砌结构接触压力增量的影响.结果表明:膨胀荷载与岩土膨胀力大小、应力水平、地层抗力、膨胀后岩土物性参数等因素有关,因地层局部膨胀引起的衬砌结构承受附加膨胀荷载值小于室内测得的膨胀力;岩土吸水膨胀后,地层抗力显著降低,对地层膨胀区及影响区隧道衬砌结构承受的荷载分布产生显著影响;若膨胀力较小,吸水后软化作用强于膨胀作用,会导致衬砌承受的荷载减小.