基于支撑树法的高速公路多路径识别问题研究

随着高速公路的不断建设,开始出现环路,路网密度不断增大,由此产生两点之间车辆行驶的多路径识别问题,是高速公路联网收费及管理中迫切需要解决的问题。通过深度优先搜索算法搜索出需要在交通网络中添加标识站的路段,把交通网络网状结构图转化为支撑树树状结构图,从而实现多路径的识别。     

The β-amyloid protein induces S100β expression in rat hippocampus through a mechanism that involves IL-1

Objective To explore the effect of β-amyloid protein (Aβ) on S100β expression in rat hippocampus and its mechanisms. Methods At 7 days after bilateral stereotaxis injection of different dose of fibrillar Aβ 25-35 and interluekin-1 receptor antagonist (IL-1ra) into the rat CA1 region, the learning and memory abilities of rats were tested with passive avoidance task. Amyloid deposition was detected by using Congo red staining technique. Nissl staining and immunohistochemical techniques were used to analyze the number of neurons, and GFAP and the S100β expression in hippocampal CA1 region , respectively. Results After fibrillar Aβ injection, the step-through latency of rats was significantly shortened compared to that of the control group. The GFAP positive astrocytes were found surrounding amyloid deposition. Neuronal loss occurred in the pyramidal cell layer of CA1 region. The number of S100β positive cells in Aβ-treated group was significantly increased compared with that in the control group. After IL-1ra injection, the number of S100β positive cells was significantly decreased. Conclusion Intrahippocampal injection of Aβ 25-35 could cause similar pathologic changes of Alzheimer's disease. Aβ 25-35 was capable of up-regulating S100β expression in a dose-dependent manner. The injection of IL-1ra could attenuate the effect of Aβ on S100β expression.     

PROLIFERATION AND MIGRATION OF EPENDYMAL CELLS IN THE BRAIN OF ADULT RATS AFTER PERMANENT FOCAL CEREBRAL ISCHEMIA

Objective Ependymal cells are thought to be the primary source of neural stem cells in the adult central nervous system. The purpose of this study is to examine spatial and temporal profiles of ependymal cell proliferation and migration after focal cerebral ischemia. Methods Eighty male Sprague Dawley rats underwent permanent middle cerebral artery occlusion after injection of 10/μL of 0.2% Dil into the lateral ventricle. Rats were sacrificed and brain sections were acquired for pathological evaluation and laser confocal imaging at day 1,3,7,11,14,21 and 28 after ischemia. Results The density of Dil-labeled cells in the ischemic ipsilateral subventricular zone was significantly higher than that in the control group and these labeled cells dispersed in the ischemic ipsilateral subventricular zone and/or were located in ependyma from day 1 to 11. In the ischemic ipsilateral cortex, some Diilabeled cells occurred in peri-infarction and infarction of parietal region at day14 and peaked at day 21 when some Dil-labeled cell nodules were found in this region. During postischemic day 14--28, a significant decrease in labeled celldensity in the ischemic ipsilateral subventricular zone was coincident with a significant increase in labeled cells density in the cortex (peri-infarction and infarction). Conclusion The results indicate that ependymal cells proliferate and migrate after focal cerebral ischemia in the adult rat brain.     

灵长类主要运动区和背侧运动前区的丘脑联系

目的　观察灵长类主要运动区和背侧运动前区的丘脑起源。方法　采用束路示踪技术 ,将 2种逆行示踪剂分别注射到猴子的主要运动区 (M 1)和背侧运动前区 (PMd)。结果　丘脑腹外核嘴侧部 (VLo) ,腹内侧核(VM ) ,腹后外侧核嘴侧部 (VPLo) ,腹外侧核尾侧部 (VLc) ,中央中核 (CM ) ,中央外侧核 (CL)和腹后内侧核(VPM )均有纤维投射到M 1。丘脑腹外侧核嘴侧部 (VLo) ,腹后外侧核的嘴侧部 (VPLo) ,腹外侧核的尾侧部(VLc)和背内侧核 (MD)则主要投射到背侧运动前区 (PMd)。结论　M1和PMd具有不同的丘脑起源 ,这种起源既有重叠也有分离 ;小脑和基底神经节通过不同的丘脑核团影响运动区皮层的活动     

高性能混凝土早期自收缩机理及诊治原理

分析了高性能混凝土的早期自收缩特点,论述了其早期自收缩机理,针对高性能混凝土自收缩集中在早期、对后期裂缝影响较大的特点,提出掺用粉煤灰,利用其早期水化速度慢来改善高强混凝土硬化速度,从而降低混凝土早期自收缩程度,提高耐久度。     

一种基于混沌序列的数字水印算法实现及分析

数字水印技术是进行数字产品保护的一种重要手段.提出了一种基于混沌序列的数字水印算法,在水印嵌入原始图像之前,利用混沌发生器生成的随机序列对水印图像进行置乱处理;水印位置的确定采用边缘提取的方法,简单易行.     

车头间距与高速公路交通流混沌

为了分析交通流混沌的转化机理，探讨了车头间距与高速公路交通流混沌的关系．提出了一种快速判别交通流混沌的最大李雅普诺夫指数改进算法，并用此改进算法和功率谱法研究了高速公路实测交通流的混沌问题，绘制了实测交通流的功率谱曲线．通过分析功率谱曲线，可以明显地观察到交通流频谱出现了噪声和宽峰的变化；用最大李雅普诺夫指数改进算法计算实测交通流的最大李雅普诺夫指数，结果表明，高速公路实测交通流中存在混沌现象．研究表明，车头间距的变化是交通流混沌现象产生的根本原因．     

肥胖高血压患者糖、脂质代谢紊乱的临床对照研究

目的观察肥胖高血压患者血脂、血糖、胰岛素指数及血清、脂肪组织中脂蛋白脂酶(LPL)含量和活性变化,探讨糖、脂质代谢紊乱与肥胖高血压及代谢综合征的发病关系。方法选取122例肥胖高血压患者及等量正常组病例进行对照研究,测定体质量指数(BMI)、腰臀围比(WHR)、血压、血脂、血糖、血胰岛素,并计算胰岛素敏感指数(ISI),部分病例测定血清及脂肪组织的LPL含量和活性。结果肥胖高血压组患者的血清甘油三脂(TG)、空腹血糖(FBS)、血胰岛素(INS)水平均显著高于对照组(P<0.01),而血清LPL含量、HDL水平、ISI显著低于对照组(P<0.01);两组间脂肪组织中LPL的含量无显著差别(P>0.05)。相关分析发现,血淸LPL含量与BMI(r=-0.64)、WHR(r=-0.59)、TG(r=-0.78)呈显著性负相关(P<0.01),与ISI(r=0.53)、HDL(r=0.46)呈正相关;脂肪组织中LPL含量及活性与上述指标均无相关性(P>0.05)。结论肥胖高血压患者多合并有糖、脂质代谢紊乱和胰岛素抵抗,血清LPL在其代谢紊乱中可能发挥重要作用。     

申嘉湖京杭古运河大桥设计浅议

针对申嘉湖高速公路京杭古运河大桥提出了预应力混凝土连续梁桥和斜拉桥两种不同的桥式方案。通过经济性、安全性、实用性、耐久性和施工等方面的比选,建议采用55m 80m 55m的变截面连续箱梁桥方案,并运用桥梁博士对主梁进行了施工阶段和使用阶段的内力计算和估索计算。验算结果表明,所选的预应力混凝土连续梁桥方案是合理的。     

固体粉末法渗钛、渗铝及钛铝共渗的研究

本文对固体粉末法渗钛、渗铝及钛铝共渗进行了研究,获得了可行的工艺方案,并揭示了渗钛层、渗铝层、钛铝共渗层的显微硬度与组织的关系。