Radiosensitivity of β-elemene on rabbit VX2 renal transplant carcinoma model

Objective To investigate the effects of low dosage ofβ-elemene on the radiosensitivity of rabbit VX2 renal transplant carcinoma model. Methods We took the rabbit VX2 renal transplant carcinoma as the model. Experimental rabbits were divided into three groups： the control group, the radiation group, and the radiation ＋β-elemene （radiosensitivity） group. The change of tumor was observed by Spiral CT and B ultrasound to compare its regrowth period. The tumor was measured by light microscopy and electron microscopy. Results The tumor in radiosensitivity group was restrained obviously and the sensitization enhancement ratio （SER） of β-elemene was 1.89. Different apoptosis was observed under transmission electron microscopy. Conclusion Low dosage β-elemene can enhance the radiosensitivity of rabbit VX2 renal transplant carcinoma model and induce the apoptosis of tumor cells, but the mechanism needs further study. It promotes apoptosis in mechanisms in vitro.     

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为了描述无信号交叉口混合车流的等待延误特性，论文建立了由大小两种车型构成的混合车流的等待延误公式。本文在分析了目前无信号交叉口延误研究方法存在某些不足的基础之上，以可接受间隙理论为基础，建立了无信号交叉口大小两种车型构成的次要车流的等待延误公式。通过选取适当的参数数据，分析了次要车流等待延误与主要车流流量、次要车流不同车型比例构成的关系，结果表明该公式较为符合无信号交叉口实际情况。     

常州市交通数据库建设经验与启示

为了更好地为城市交通规划提供翔实的基础资料和科学化的评测手段,交通数据库的建设势在必行.首先介绍了常州市交通数据库的建设背景及意义,然后回顾整个交通数据库的建设流程,通过成立专门的调查机构,制定科学的调查方法,加上强强联合、优势互补的咨询单位和出色的总体策划,成功地完成了交通数据库的建设.最后,总结了一些不足之处,如项目时间不充足,数据库总体设计反馈延误,调查方案未得到全面落实,部分现状基础数据还有待补充,人才培养未跟上等等.     

U型桥台构造型式探讨

U型桥台是公路桥梁下部结构常用的构造，在工程实践中，U型桥台常常出现开裂．依据规范的有关条文，结合有限元数值分析结果，给出了常用桥台的构造内坡比和增设桥台外坡的建议值；进一步提出了改善桥台受力和减小变形的措施和设计方法，包括在前墙与侧墙交汇处增设倒角、前墙与侧墙外侧设置钢筋砼圈梁、在侧墙两侧设置预应力砼拉筋法或钢筋砼拉梁法等，供设计和加固时参考．     

PRELIMINARY STUDY OF OMENTUM TRANSPOSITION TO BRAIN FOR TREATMENT OF ALZHEIMER'S DISEASE

Objective To learn the effect of omemtum transposition to the brain of patients with Alzheimer's disease. Methods Ten consecutive patients, aged 58 - 81 years old, underwent graft of their elongated pedicled omentum onto their left frontal-temperal-parietal cerebral cortex. Those patients, who had more than five years of dementia with low mini mental-state examination (MMSE) scores of 2 -15, were diagnosed by a neurologist. All subjects underwent single photon evoked computer tomography (SPECT) pre- and post-operatively.SPECT results were analyzed semi-quantitatively by calculation of the left/right radioactivity counts symmetry index (Si). The patients were followed up to one year. The outcome was evaluated by the neurologist with a modified scale of activities of daily living (mADL) as well as the MMSE. Results Three months following the surgery,the Si of SPECT increased from ( 98. 7 ± 1.9) % to ( 103. 9 ± 2.3 ) % ( P = 0. 0307). The neurological and neuropsychological testing scores increased insignificantly during the follow-up period. By the one year, the MMSE score rose from 8. 7 ± 1.4 to 10. 7 ± 1.8 ( P ＞ 0. 05 ), while the mADL from 13.3 ± 1.8 to 16. 9 ± 2. 0 ( P ＞ 0. 05 ). One of the patients suffered a heart attack, two had epileptic episodes postoperatively. Conclusion We believe that omental transposition to the brain augments cerebral blood flow, which might be helpful to decelerate the processing of Alzheimer's disease. However, it is still a potentially risky procedure for the elderly.     

北京市公共交通票制票价改革的交通影响评估

通过采集北京市公共交通客运量、客流压力、乘客乘车距离、票价水平等方面的数据,并借助乘客出行意愿调查,分析了公共交通票制票价改革对城市交通特别是公共交通运行的影响。     

CT reconstruction with priori MRI images through multi-group datasets expansion

Computed tomography (CT) reconstruction with a well-registered priori magnetic resonance imaging (MRI) image can improve reconstruction results with low-dose CT, because well-registered CT and MRI images have similar structures. However, in clinical settings, the CT image of patients does not always match the priori MRI image because of breathing and movement of patients during CT scanning. To improve the image quality in this case, multi-group datasets expansion is proposed in this paper. In our method, multi-group CT-MRI datasets are formed by expanding CT-MRI datasets. These expanded datasets can also be used by most existing CT-MRI algorithms and improve the reconstructed image quality when the CT image of a patient is not registered with the priori MRI image. In the experiments, we evaluate the performance of the algorithm by using multi-group CT-MRI datasets in several unregistered situations. Experiments show that when the CT and priori MRI images are not registered, the reconstruction results of using multi-group dataset expansion are better than those obtained without using the expansion.     

集装箱船舶装箱排序问题的两阶段算法

集装箱船舶装箱排序问题综合集装箱装船顺序与船舶贝内排箱,是一类典型的组合优化问题.考虑堆场发箱顺序和船舶配载之间的关联,构建集装箱船舶装箱排序问题的数学模型.针对构建的优化模型,鉴于已有方法难以直接对其进行求解,基于两阶段分层求解思想设计SWO-HES两阶段算法.算法第1阶段利用吱呀轮算法(SWO)大邻域导向式搜索的特点优化集装箱装船顺序问题;第2阶段将SWO的结果作为输入,基于启发式规则和演化策略算法(ES)构造混合演化策略算法(HES)优化船舶贝内排箱问题.最后,通过不同规模算例的研究,将SWO-HES与常见智能算法、基于实际装船规则的启发式算法进行对比分析,验证模型与算法的有效性.     

基于偏好顺序集的非补偿式铁路旅客选择行为估计方法

精细化需求预测是铁路提高收益的重要基础.本文考虑了铁路产品属性对于旅客选择行为的影响,构建具有一定偏好顺序的产品集合来表征不同类型的旅客.在此基础上,利用客票存根及余票数据,建立预售期内旅客选择过程的极大似然函数,求解得到不同旅客类型的出现概率.首先通过仿真算例验证了模型的计算可行性,然后通过实证数据,估算了北京南至上海虹桥方向不同旅客类型在各时段的出现概率,进一步统计得到旅客在不同时段下铁路旅客buy-up行为概率及属性敏感度的变化,并提出一些可用于优化售票策略的建议.     

结合VR技术的汽车制动方向稳定性探讨

在受到侧向力的情况下,进行了整车制动过程的建模和仿真。仿真结果表明:ABS系统以滑移率为控制对象,可提高汽车制动时的方向稳定性,对整车制动的安全性有重要作用。通过VR技术可使仿真结果直观的表现。