Can mixed logit reveal the actual data generating process? Some implications for environmental assessment

Recent advances in the specification of the utility function of mixed logit models allow the analyst, in principle, to consider a vast variety of individual heterogeneity. Nevertheless, when estimating the model it is common practice to experience severe difficulties in discriminating between different specifications to infer the “true” data generating process. We investigate possible sources for this difficulty focusing on the confounding effects inherent in two basic assumptions of discrete choice model utilities: linearity in the parameters and added error terms. We analyse the role of these assumptions in giving rise to confounding effects and why this increases the difficulty of discriminating among different structures. Finally, we investigate how these problems may affect benefit appraisal using these models. Empirical evidence is provided for two different environmental contexts and a more typical transport context using various kinds of data.     

桥梁支座典型病害分析及对策

随着桥梁建设的飞速发展和荷载等级的不断提高,支座也被广泛地使用于桥梁中,同时也出现了支座使用、安装和耐久性问题等等,这些问题都是影响结构安全性和耐久性的重要因素,需要通过科学手段、方法加以诊断、评价。     

二尖瓣脱垂综合征患者QT离散度分析

测定了30例二尖瓣脱垂综合征伴室性心律失常患者的QTd。结果发现，二尖瓣脱垂组QTd、QTcd、JTd显著延长，说明心室肌复极有局部的不均一性和电不稳定性，离散度与室性心律失常的发生密切相关，可能是室性心律失常发生的机理之一。QTd不仅能预测室性心律失常及猝死，而且能指导临床用药，是一很好的临床观察指标。     

Carrier冷藏集装箱微电脑控制器常见故障及检测

本文阐述了Carrier冷藏集装箱微电脑控制器常见的不显示不工作,锂电池报警,供风、回风温度报警等故障的原因及检测方法.     

我国铁路货运集中化推进模式的研究

铁路广泛实行货运集中化,成为铁路运输组织现代化的主要发展趋势之一。在研究国内外铁路货运集中化的基础上,分析铁路货运集中化的经济效益,提出了我国实施铁路货运集中化的阶段推进模式。     

不规则波作用下带挑檐直立堤爬高与越浪量试验

通过物理模型实验,对带挑檐直立堤在不规则波作用下的爬高和越浪量进行观测,分析墙顶超高、挑檐宽度以及波坦等影响因素。结果表明:直立堤波浪爬高主要与波高有关,周期影响不大;堤顶超高、挑檐宽度和波坦是直立堤越浪量的重要影响因素,但挑檐宽度对直立堤越浪量的影响程度与堤顶超高有关。根据试验结果,提出了直立堤波浪爬高和越浪量计算方法,为实际工程设计提供参考。     

Spatial impacts of road pricing: Accessibility, regional spillovers and territorial cohesion

Road pricing policies are gaining prominence in EU countries. These policies have positive impacts leading to mobility patterns which are socially and environmentally more desirable, but they also have negative impacts. One negative impact is to be found in regional accessibility, due to the increase in generalized transport costs. This study presents a methodology based on accessibility indicators and GIS to assess the accessibility impacts of a road pricing policy. The methodology was tested for the Spain’s road network considering two road pricing scenarios. It enables not only the more penalized regions to be identified but also negative road pricing spillover effects between regions. These effects are measured in terms of accessibility changes occurring in one region produced by charges implemented in another region. Finally, the study of accessibility disparities (by calculating inequality indexes for each of the scenarios considered), provides policymakers with useful information regarding the impact of road pricing policies from the point of view of territorial cohesion.     

siRNA沉默MAPK p42对肝癌SMMC7721增殖和凋亡的影响

目的应用siRNA沉默SMMC7721细胞MAPK p42,并观察其对增殖和凋亡的影响。方法应用SilencerTMsiRNA构建试剂盒合成2条MAPK p42siRNAs和一条随机对照siRNAs,用脂质体LipofectaminTM 2000将其转染入肝癌SMMC-7721细胞株。应用Western blot检测MAPK p42表达,MTT法检测细胞增殖情况,流式细胞仪分析细胞周期及其细胞凋亡。结果与对照相比,MAPK p42siRNA明显抑制MAPK p42表达。MAPK p42siRNA抑制了SMMC-7721细胞的生长,将细胞阻滞于细胞周期S期,进而诱导了细胞凋亡的发生。结论 MAPK p42靶向siRNA可能为肝癌基因治疗的重要手段。