原发性小血管炎患者多系统临床表现和肾脏病理分析

目的分析原发性小血管炎患者多系统的临床表现和肾脏病理特点。方法选取我院1996年1月至2007年8月间明确诊断的原发性小血管炎患者共78例,患者均有肾脏损害,并行肾活检,总结分析患者的临床病理资料。结果78例中15例胞浆型抗中性粒细胞胞浆抗体(cANCA)阳性,均识别蛋白酶3(PR3);62例环核型抗中性粒细胞胞浆抗体(PANCA)阳性,均识别髓过氧化物酶(MPO)。临床表现呈多器官受累:不规则发热;浮肿、血尿、蛋白尿、肾功能减退;咳嗽、咯血、胸痛、肺部浸润;鼻塞伴有脓性分泌物;关节肿痛等。肾活检可见小血管壁节段性纤维素样坏死,新月体多见。免疫荧光无免疫球蛋白或微量免疫球蛋白及补体C3沉积。治疗采用糖皮质激素联用细胞毒药物或吗替麦考酚酯,部分患者同时给予透析治疗,治疗有效率达85.9%。结论原发性小血管炎并不少见,且以显微镜下型多血管炎居多;患者以中老年为主;ANCA检测有助于早期诊断及复发判断;及时治疗可逆转。     

KCNE2蛋白在自发性高血压大鼠心脏组织中的分布和表达

目的研究KCNE2蛋白在自发性高血压大鼠(SHR)心脏不同部位的分布和表达差异,及鼠龄对其表达水平的影响。方法提取幼龄和高龄SHR心肌不同部位(心室、室隔膜和心房)组织的膜蛋白,利用Western印迹技术和图象分析方法,比较KCNE2蛋白在样品之间免疫强度差异。结果SHR心肌不同部位组织中均有KCNE2蛋白的分布;同龄大鼠心肌不同部位组织中KCNE2蛋白的表达均无显著性差异;但在高龄大鼠的右心室和室隔膜组织中,KCNE2蛋白的表达显著高于其在幼龄大鼠相同组织中的表达。结论KCNE2蛋白在SHR心脏不同部位均有分布;在高龄大鼠右心室和室隔膜组织中,KCNE2蛋白的表达水平均高于其在幼龄大鼠同一组织中的表达。     

列车空气制动均衡速度的局部稳定性

为了研究空气制动工况下列车均衡速度的稳定性,分析了列车均衡速度与单位合力函数单调性的关系.当单位合力函数单调递减时,列车均衡速度稳定,否则,其均衡速度不稳定.因此,在空气制动工况下,单位合力函数在部分速度区间单调递减,均衡速度存在局部稳定性,并采用二分法计算了均衡速度稳定的速度区间.以SS4型机车牵引中磷闸瓦空货车为例,列车运行限速和制动初速度为100 km/h,其临界速度为53.5 km/h,当列车速度为53.5~100 km/h时,空气制动下均衡速度是稳定的.     

西安市城区绝经后妇女骨密度与女性生理因素的相关性

目的探讨绝经后妇女女性生理因素与腰椎、髋部骨密度的关系。方法对西安市城区281名绝经后妇女进行了女性生理因素的流行病学调查,并测定了腰椎、髋部骨密度。结果相关分析显示年龄、绝经年限、生育活产子女数和骨密度均呈显著负相关(P<0.01),而行经年限、身高、体重及体重指数(BMI)和骨密度均呈显著正相关(P<0.01)。比较骨质疏松组、骨量减少组和骨量正常组,年龄、绝经年限、生育活产子女数等,骨质疏松组明显高于骨量减少组和正常组(P<0.05);而平均每次月经持续天数、行经年限、身高、体重、BMI等,骨质疏松组明显低于骨量减少组和正常组(P<0.05)。结论西安市城区绝经后妇女的年龄、行经年限、绝经年限、生育活产子女数、身高、体重和BMI等与其腰椎和髋部的骨密度有明显的相关性。     

Explaining obesity with urban form: a cautionary tale

In recent years, there has been a dramatic increase in studies exploring associations between the built environment and obesity. Many studies have found that built environment characteristics, such as high-density land developments, mixed-land uses, and connected street networks, are associated with lower rates of obesity. However, depending on the research field and the researcher, how one specifies the experimental model and how sociodemographic characteristics of the population are defined and included in the model has led to different policy conclusions and implications. This is not a surprising observation; however, it is one that does seem to have been lost in current discussions. This article highlights several data-processing, model-specification, and model-estimation factors that should be comprehensively considered in studies of the built environment and obesity. Empirical results based on data from Atlanta, GA, USA, illustrate that the association between the built environment and obesity is sensitive to how age, income, and educational attainment are included in the model. Also, a detailed examination of land-use-mix measures shows that it is difficult to create this measure and that results are sensitive to the treatment of missing values. Models that distinguish between overweight and obese individuals are shown to provide richer insights into the associations among obesity, built environment, and sociodemographic characteristics for the Atlanta area. The article concludes by offering modeling recommendations for future studies.

浅谈如何根据驾校学员心理特征因材施教

多年从事汽车驾驶教员工作 ,针对数学中出现的各种问题 ,经过多年的潜心研究 ,终于得出了一些独特见解 ,即必须根据学员的心理特征因材施教、因人施教 ,才能提高教学质量 ,完成好汽车驾驶教员工作。     

Local shopping as a strategy for reducing automobile travel

Transportation - Suburban development in the US is widely criticized for its contribution to automobile dependence and its consequences. Not surprisingly, then, a return to more urban-style...     

梯形动铁式交流焊机优化设计研究

对梯形动铁式交流焊机的优化目标进行了探讨,在此基础上建立了动铁式交流焊机优化设计的数学模型,编制了计算机优化设计软件,利用该软件对焊机进行了优化设计,结果表明:利用该软件所设计的交流焊机具有较低的制造成本和较高的综合性能     

灌砂法在路基压实度检测中的应用

结合工程实践,浅谈灌砂法在路基压实度检测中的应用.     

Optimization of isolation structure under wind load excitation and experimental study of the wind resistant bearing

The method of collaborative work between steel plate anti-wind bearing (AWB) and rubber isolation bearing is proposed to study the vibration reduction effect of isolation structure under stronger wind load, and the function mechanism is explained. Based on a practical project, three kinds of schemes with different isolation layers are put forward, the finite element software ETABS is used for time history analysis, and comparison is made on the seismic response of different isolated structure and aseismic structure. Comparison result shows that the isolation layer with rubber bearing and AWB can work reasonably, but further optimization on the designed parameters is needed. Moreover, the design value of horizontal bearing capacity of lead rubber bearing (LRB) is appropriate to be close to the seismic isolation layer under wind load excitation. Finally, numerical simulation and comparative analysis of shear test of the AWB are conducted. With a very small yield displacement and yield strength over 80% of the set of horizontal bearing capacity, the AWB is validated to satisfy the working conditions which provide the horizontal bearing capacity under normal operating conditions and designed earthquake. The AWB yields and malfunctions, when the maximum displacement is less than the displacement of the isolation layer.