水泥-乳化沥青碎石混合料配合比设计方法研究

C-ETM混合料路用性能优于半刚性基层,而造价却低于普通热拌沥青碎石基层,更适应国内、特别是西部地区的技术经济条件。依据C-ETM混合料的材料组成和强度形成特点,结合室内试验,对C-ETM混合料的配合比设计方法进行研究,提出适应于C-ETM混合料特点的配合比设计方法。     

港口集装箱传送分配系统的分类比较研究

港口集装箱装卸传输的工作效率是码头竞争力的核心,在不同的码头条件下,只有采用合适的集装箱装卸传输系统才能使作业效率达到最佳。基于这个目标,分别以系统构成、效率、优劣点、适用条件为考核标准,对现今港口集装箱装卸传输进行传统系统和新型系统的横向比较及分析,为因地制宜地采用合适的集装箱传输系统提供理论依据。     

限速坡与减速带的设置标准比较

目前国内社区中广泛采用的限速装置(减速带)具有诸多问题,而限速坡在限速效果、对道路交通流的影响、可见性、交通噪声等方面较减速带好,就整体效果来讲,采用限速坡作为我国社区的道路限速装置,更有助于社区交通安全.     

列车牵引系统网侧过流故障实时诊断与保护策略研究

目前机车和动车组牵引系统网侧过流故障存在诊断与保护方式单一且无法准确定位具体故障源的问题,因此提出了一种基于决策树模型的实时诊断方法:通过离线分析网侧过流故障的相关信号,得出其故障特征量并建立决策树模型;实时采集运行过程中的信号并计算其故障特征量,基于决策树模型来实现故障的准确定位;根据故障诊断结果采取不同保护策略,以...     

隧道坡度因素对柴油车烟雾排放量的影响

通过发动机台架模拟, 控制吸入气缸一定废气量而营造隧道污染环境, 进行柴油车在实际道路坡度运行时动态烟雾排放测试, 以及在实际隧道环境下, 柴油车坡度运行时动态烟雾排放测试, 获得在不同坡度环境下柴油车烟雾排放的道路实测数据。结果分析表明, 随着道路坡度的增加, 柴油车烟雾排放量急剧上升, 而在相同坡度下, 车速越高烟雾排放量越大, 且隧道内坡度每增加1 %, 柴油车烟雾排放量大约增加70 %~ 1 2 0 %。     

LED灯具在高速列车照明系统中的应用

随着我国高速铁路事业的发展,旅客对车内照明环境品质的要求越来越高,在我国高速列车照明设计中广泛采用LED灯具作为光源。通过对高速动车组车载灯具与25T型列车传统车载灯具的测试对比,总结出LED灯具在发光效率等方面相对于传统灯具的优势,为高速动车组室内照明设计提供依据。     

Modelling,simulation and applications of longitudinal train dynamics

ABSTRACT

Significant developments in longitudinal train simulation and an overview of the approaches to train models and modelling vehicle force inputs are firstly presented. The most important modelling task, that of the wagon connection, consisting of energy absorption devices such as draft gears and buffers, draw gear stiffness, coupler slack and structural stiffness is then presented. Detailed attention is given to the modelling approaches for friction wedge damped and polymer draft gears. A significant issue in longitudinal train dynamics is the modelling and calculation of the input forces – the co-dimensional problem. The need to push traction performances higher has led to research and improvement in the accuracy of traction modelling which is discussed. A co-simulation method that combines longitudinal train simulation, locomotive traction control and locomotive vehicle dynamics is presented. The modelling of other forces, braking propulsion resistance, curve drag and grade forces are also discussed. As extensions to conventional longitudinal train dynamics, lateral forces and coupler impacts are examined in regards to interaction with wagon lateral and vertical dynamics. Various applications of longitudinal train dynamics are then presented. As an alternative to the tradition single wagon mass approach to longitudinal train dynamics, an example incorporating fully detailed wagon dynamics is presented for a crash analysis problem. Further applications of starting traction, air braking, distributed power, energy analysis and tippler operation are also presented.     

Effects of rosiglitazone on rabbit atherosclerosis

We sought to validate magnetic resonance imaging(MRI) for documenting the effects of rosiglitazone on rabbit atherosclerosis and the possible mechanism by treatment on the lesions.24 New Zealand white rabbits were randomly divided into normal group, control group and treatment group.After 4 weeks, all rabbits underwent MRI.After examination, the number of circulating endothelial progenitor cells(EPCs) and level of lipid, glucose, nitric oxide(NO) and superoxide anion(O-2·) were measured.MRI demonstrated the regression of atherosclerotic lesions by rosiglitazone which has good correlation with histopathology.Treatment not only increased the level of EPCs and NO, but also raised the ability of inhibition of O2-·.MRI is a promising noninvasive technology to detect the effects of therapeutic interventions.Rosiglitazone slows the progression of atherosclerosis that may in part attribute to its improvement of mobilization of EPCs and the reduced oxidative stress.     

RNA结合蛋白La对宫颈癌细胞侵袭转移的影响及其机制

目的探讨RNA结合蛋白La(La)对宫颈癌细胞侵袭转移的作用及其作用机制。方法采用RNA干扰技术沉默La基因在宫颈癌细胞株HeLa中的表达,并通过G418筛选,构建稳定表达的HeLa的La干扰克隆。采用划痕实验、Transwell小室等检测La对宫颈癌细胞侵袭转移的影响。利用Western blot的方法检测细胞中基质金属蛋白酶2(MMP-2)和基质金属蛋白酶抑制剂2(TIMP-2)的表达,并采用明胶酶谱的方法检测细胞培养上清中MMP-2的活性。结果 La干扰后细胞的迁徙和侵袭能力明显降低,对细胞迁徙距离和穿过Transwell小室的细胞数目进行分析后发现,差异有统计学意义;同时发现在细胞中MMP-2的蛋白表达水平及酶活性均降低,而TIMP-2的蛋白表达水平上调。结论 La对宫颈癌的侵袭转移具有促进作用,这种作用可能与其对基质金属蛋白及其抑制剂的调控相关。