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We sought to validate magnetic resonance imaging(MRI) for documenting the effects of rosiglitazone on rabbit atherosclerosis and the possible mechanism by treatment on the lesions.24 New Zealand white rabbits were randomly divided into normal group, control group and treatment group.After 4 weeks, all rabbits underwent MRI.After examination, the number of circulating endothelial progenitor cells(EPCs) and level of lipid, glucose, nitric oxide(NO) and superoxide anion(O-2·) were measured.MRI demonstrated the regression of atherosclerotic lesions by rosiglitazone which has good correlation with histopathology.Treatment not only increased the level of EPCs and NO, but also raised the ability of inhibition of O2-·.MRI is a promising noninvasive technology to detect the effects of therapeutic interventions.Rosiglitazone slows the progression of atherosclerosis that may in part attribute to its improvement of mobilization of EPCs and the reduced oxidative stress. 相似文献
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高速公路的路堤一般都比较高,且桥涵较多,与一般公路相比,行车速度快,交通量大,对路基路面的要求更高。修建的高速路在穿越具有不良地基的地段时,不仅要求路堤稳定,而且对差异沉降和沉降变形特别是工后不均匀沉降量均有较高的要求。故如何减小工后沉降、减小偏压荷载以保证桥台的稳定,成为在湿软地基上修建桥梁需要重视和解决的问题。 相似文献
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Travel Behavior Analysis of the Females in Beijing 总被引:1,自引:0,他引:1
Meng ZHANG Quanxin SUN Jinchuan CHEN Jifu GUO 《Journal of Transportation Systems Engineering and Information Technology》2008,8(2):19-26
In urban life, compared with the same age group of male contrast, the statistical indicators of female travel behavior show significant differences. According to the sample data of Beijing 2005 travel survey, the paper analyzes the female travel behavior in the travel rate, travel consumption, trip purpose, and travel mode. Furthermore, the paper introduces the concept of the trip chain, to construct a female morning commuter trip chain choice behavior model with noncollection theories and methods, to analyze 10 factors that influence a female individual's choice of a trip chain from the source. Subsequently, model parameters are estimated, to calculate the incidents that can help to quantitatively understand the impact of each factor on a female's choice of the trip chain. The results show that the travel rate of elderly women is far lower than that of elderly men. Female travel proportion in shopping and social activities is obviously higher than that of male travelers, and factors related to the structure of families create important constraints in their average travel time consumption. The main travel mode of the female is walking, which is far more than that of a male. Age, whether they hold licenses, monthly income, and transport ownership are dominant factors for the female's choice of the trip chain. 相似文献
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Frank-Wolfe�㷨��⽻ͨ��������: �Ƚϲ�ͬ�������²��Ժ����������� 总被引:1,自引:0,他引:1
Frank-Wolfe(FW)算法是一类广泛应用于求解交通分配问题的算法。它具有容易编程实现,所需内存少的特点。但是该算法收敛速度较慢,不能得到路径信息。为了提高算法的效率,本文研究三种流量更新策略(all-at-once, one-origin-at-a-time, one-OD-at-a-time)以及不同的步长搜索策略下的FW算法,其中步长搜索策略包括精确线性搜索方法(包括二分法、黄金分割法、成功失败法)和不精确的线性搜索方法(包括基于Wolfe-Powell收敛准则的搜索方法和Gao等提出的非单调线性搜索方法)。最后,本文将上述策略应用于四种不同规模的交通网络中,并给出较适合求解的组合。 相似文献