抑郁症患者血清甲状腺激素水平变异分析

目的　了解血清甲状腺激素水平与抑郁症的关系。方法　对 6 4例门诊及住院抑郁症患者中双相抑郁障碍 34例、单相抑郁障碍 30例治疗前后血清三碘甲状腺原氨酸 (T3 )、甲状腺素 (T4)和促甲状腺激素 (TSH)进行检测 ,同时以30名健康志愿者作为对照组。治疗前后应用汉密尔顿抑郁量表 (HAMD)和Montgomery Asbery抑郁量表 (MADRS) ,评定抑郁症状的严重程度。结果　患者组治疗前后T3 [(1.98± 0 .5 2 )nmol·L-1,(1.90± 0 .5 8)nmol·L-1]均明显高于对照组 [(1.5 8± 0 .2 7)nmol·L-1],单相抑郁障碍患者治疗后T4[(93.4 1± 2 9.4 1)nmol·L-1]低于治疗前 [(10 4± 2 0 .2 4 )nmol·L-1],并恢复到正常范围 ,HAMD和MADRS评分也随之明显下降。结论　提示抑郁症患者甲状腺激素水平改变与症状的消失有关 ,甲状腺激素异常是继发于情绪障碍 ,双相抑郁障碍与单相抑郁障碍在病因学方面可能不同。     

THE GENE EXPRESSION OF BDNF IN NORMAL RABBIT RETINA

Objective To investigate the distribution of brain-derived neurotrophic factor(BDNF) protein in the rabbit retina. Methods Immune response material in the retina was observed using BDNF antibody by the method of immunohistochemistry. Results BDNF gene expression was mainly found in the RGCs, also in innernuclei cells and outernuclei cells in rabbit retina. Conclusion RGC is not only the target cell of BDNF, but also express the BDNF protein. BDNF from multi-sources participates in the regulation of RGCs.     

Decomposing and Cluster Refinement Design Method for Application-Specific Network-on-Chips

Along with higher and higher integration of intellectual properties (IPs) on a single chip, traditional bus-based system-on-chips (SoC) meets several design difficulties (such as low scalability, high power consumption, packet latency and clock tree problem). As a promising solution, network-on-chips (NoC) has been proposed and widely studied. In this work, a novel algorithm for NoC topology synthesis, which is decomposing and cluster refinement (DCR) algorithm, has been proposed to minimize the total power consumption of application-specific NoC. This algorithm is composed of two stages: decomposing with cluster generation, and cluster refinement. For partitioning and cluster generation, an initial low-power solution for NoC topology is generated. For cluster refinement, the clustering is optimized by performing floorplan to further reduce power consumption. Meanwhile, a good tradeoff between power consumption and CPU time can be achieved. Experimental results show that the proposed method outperforms the existing work.     

Research on Web Page Classification Method Based on Query Log

Web page classification is an important application in many fields of Internet information retrieval, such as providing directory classification and vertical search. Methods based on query log which is a light weight version of Web page classification can avoid Web content crawling, making it relatively high in efficiency, but the sparsity of user click data makes it difficult to be used directly for constructing a classifier. To solve this problem, we explore the semantic relations among different queries through word embedding, and propose three improved graph structure classification algorithms. To reflect the semantic relevance between queries, we map the user query into the low-dimensional space according to its query vector in the first step. Then, we calculate the uniform resource locator (URL) vector according to the relationship between the query and URL. Finally, we use the improved label propagation algorithm (LPA) and the bipartite graph expansion algorithm to classify the unlabeled Web pages. Experiments show that our methods make about 20% more increase in F1-value than other Web page classification methods based on query log.     

Research on Spatially Adaptive High-Order Total Variation Model for Weak Fluorescence Image Restoration

Photoacoustic imaging acquires the absorption contrast of biological tissue with ultrasound resolution. It has been broadly investigated in biomedicine for animal and clinical studies. Recently, a micro-electro-mechanical system (MEMS) scanner has been utilized in photoacoustic imaging systems to enhance their performance and extend the realm of applications. The review provides a recap of recent developments in photoacoustic imaging using MEMS scanner, from instrumentation to applications. The topics include the design of MEMS scanner, its use in photoacoustic microscopy, miniature imaging probes, development of dual-modality systems, as well as cutting-edge bio-imaging studies.     

大型体育赛事交通战略研究

大型体育赛事对城市客运交通和物流保障等方面带来巨大挑战,迫切需要城市政府制定相关交通战略.基于大型体育赛事交通需求构成和特征分析,从短时高强度客流、高品质交通保障能力、绿色交通等方面研讨赛事给城市交通带来的挑战.为应对这些挑战,需要从城市和赛事两方面制定对应战略.城市层面,需要着眼于长远发展目标,以赛事为契机推动空间结...     

最小化网络总时延启发式遗传算法

路由选择算法是用于决定计算机网络每个结点输入的信息包应当从哪一个输出线路发送出去,以便使得某种指定的费用最小。提出了一种新的有效启发式遗传路由算法,以使网络总时延最小。该算法采用了启发式遗传路由方案,从而获得近似最优解。采用遗传算法的方法可以减少网络路由算法的运算规模,实现逐步求解。与其他已知类似算法相比较,该算法具有较小的时间复杂性。     

我国交通事故现状及预防对策研究

对比分析了我国与发达国家交通事故状况，分析我国交通事故的特点，提出了预防和减少我国交通事故的对策，希冀促进我国道路交通安全水平的提高。     

STUDY ON THE THERAPEUTIC EFFECTS OF GINSENOSIDE Rg-1 AND GASTRODINE ON AD MODEL RATS INDUCED BY β-AMYLOID PEPTIDE （25-35）

Alzheimer sdisease(AD)isadegenerativedis orderofcentralnervoussysteminhumanbeing.It ischaracterizedbylossofmemory,cognitivede clineandmisbehavior,aswellasoxidativedamage isincreasedandmetabolicrateisdecreased.Major pathologicalmarksofADareextracellarsenil…     

5-氮胞苷对宫颈癌细胞系DAPK1异常甲基化的影响

目的　观察宫颈癌细胞系SiHa及HeLa中凋亡相关蛋白激酶 1(DAPK1)的表达与甲基化修饰之间的相关性,以及5 氮胞苷对细胞DAPK1表达和生长的影响。方法　应用甲基化特异性PCR法分析细胞中DAPK1的甲基化状态;采用RT- PCR及免疫组化SABC法检测不同浓度 5- 氮胞苷干预对宫颈癌细胞 DAPK1 mRNA及蛋白表达的影响;MTT法观察5 -氮胞苷对细胞增殖的影响。结果　DAPK1基因在宫颈癌细胞 SiHa中有甲基化修饰,5- 氮胞苷干预能使其甲基化的DAPK1基因重新表达并抑制细胞生长。结论　DAPK1 的甲基化修饰是宫颈癌发生重要机制之一,5 -氮胞苷能使甲基化的DAPK1去除甲基化修饰,重新表达并恢复抑癌作用。