高应力软岩隧道超前导洞法应力释放试验研究

隧道穿越高地应力软弱围岩时,常常发生大变形地质灾害。隧道大变形灾害危害程度极大,主要表现为处理风险大、整治费用高、工期被延误。预防和治理高应力软岩隧道大变形是隧道工程界的一个重难问题。文章通过在兰渝铁路木寨岭隧道和毛羽山隧道进行超前导洞应力释放试验,得出了超前导洞法应力释放对大变形的控制作用。试验结果表明,在隧道内设置的超前导洞与隧道拱顶及边墙距离约3m左右时,超前导洞一般在3~7 d内达到应力释放效果;,正洞扩挖时变形量可减少约30%~40%。与不采用超前导洞法相比,正洞扩挖时变形量可减少约30%~40% 。     

Examining the effect of land-use function complementarity on intra-urban spatial interactions using metro smart card records

Transportation - Spatial interaction is an important phenomenon that reflects the human–land relationship and has long been a core topic in multiple fields, such as urban planning,...     

面向互联互通的全自动运行系统测试方案

全自动运行系统是未来智能化、智慧化发展的方向。以FAO互联互通需求为出发点,针对FAO互联互通系统的特点,搭建适合互联互通的全自动运行系统测试环境,提出FAO系统互联互通测试方案。     

街道设计导则与城市道路系统的优化提升 ——从通行能力到空间品质的转变

街道作为城市中承担交通、活动、生态等多重功能的重要公共空间,其品质提升与精细化设计受到越来越多的重视.街道设计导则作为一种新型的道路空间专项研究,近年来在国内外城市方兴未艾.通过对国内外城市街道设计导则编制和学术研究情况进行全面系统的回顾与梳理,总结其编制经验,对中国城市街道设计导则编制的理念目标、体例和主要内容等方面进行特征分析.进一步反思城市道路交通规划的理念与目标,提出街道设计导则对城市道路交通规划的独特借鉴价值,并探索两者之间的良性互动策略.     

铁路信号集中监测系统安全隔离机制研究

随着铁路信息化的快速发展,铁路多个系统之间实现了互联互通、信息共享和协同工作。然而不同安全等级的业务系统进行通信也带来了一系列严重的网络安全威胁。通过网络物理安全隔离技术.可以将信号集中监测系统(CSM)和列车运行控制系统(CTCS)之间的网络通信协议剥离,有效阻断网络入侵和病毒传播.保障列车运行控制系统的网络安全。     

Research of Springing and Whipping Influence on Ultra-Large Containerships’ Fatigue Analysis

Rules of Classification Societies all around the world have made changes on design wave loads’ value and fatigue influence factor modification due to the influence of springing and whipping on ultra-large containerships. The paper firstly introduced 3-D linear hydroelastic theory in frequency domain and 3-D nonlinear hydroelastic theory in time domain, considering large amplitude motion nonlinearity and slamming force due to the severe relative motion between ship hull and wave. Then the spectrum analysis method and time domain statistical analysis method were introduced, which can make fatigue analysis under a series of standard steps in frequency and time domain, respectively. Finally, discussions on the influence factor of springing and whipping on fatigue damages of 8500TEU and 10000TEU containerships with different loading states were made. The fatigue assessment of different position on the midship section was done on the basis of nominal stress. The fatigue damage due to whipping can be the same as the fatigue damage due to springing and even sometimes can be larger than the springing damage. Besides, some suggestions on calculating load case selection were made to minimize the quantity of work in frequency and time domain. Thus, tools for fatigue influence factor modification were provided to meet the demand of IACS-UR.     

1-磷酸鞘氨醇在人胃癌细胞与血管内皮细胞增殖中的作用

目的　 1 磷酸鞘氨醇是新发现的细胞外递质和细胞内第二信使。研究它在人胃癌细胞与血管内皮细胞的增殖及凋亡调控中的作用。方法　光镜观察二甲基鞘氨醇作用前后的细胞形态 ;MTT法检测细胞的增殖能力 ;电镜观察细胞的超微结构及有无凋亡发生。结果　①抑制 1 磷酸鞘氨醇生成后 ,胃癌细胞与血管内皮细胞形态发生明显变化。②二甲基鞘氨醇几乎可以完全抑制两种细胞的增殖。③一定剂量时可诱导两细胞凋亡。结论　 1 磷酸鞘氨醇在人胃癌细胞与血管内皮细胞的形态、增殖和凋亡的调控中起重要作用。     

RXPERIMENTAL AND CLINICAL STUDY OF CREATINE KINASE BB ACTIVITY FOR TH E DIAGNOSIS ON BRAIN DAMAGE

Ｔｈｅｂｒａｉｎｔｙｐｅｃｒｅａｔｉｎｅｋｉｎａｓｅｉｓｏｅｎｚｙｍｅ(ＣＫ ＢＢ)ｉｎｃｅｒｅｂｒｏｓｐｉｎａｌｆｌｕｉｄ(ＣＳＦ)ｈａｄｃｌｏｓｅｒｅｌａｔｉｏｎｓｗｉｔｈｈｅａｄｉｎｊｕｒｙ ,ｗｈｉｃｈｈａｄａｔｔｒａｃｔｅｄｐｅｏｐｌｅ’ｓａｔｔｅｎ ｔｉｏｎ[1] .Ｈｏｗｅｖｅｒ,ｔｈｅｒｅｗｅｒｅｆｅｗｓｔｕｄｉｅｓａｂｏｕｔｔｈｅｄｉ ａｇｎｏｓｉｓｏｎｈｅａｄｉｎｊｕｒｙｖａｌｕｅｏｆＣＫ ＢＢ ,ａｎｄｐｒｏｇｎｏ ｓｉｓ .Ｉｎｏｒｄｅｒｔｏｓｔｕｄｙｔｈｅｄｉａｇｎｏｓｉｓａｎｄｐｒｏｇｎ…     

MOLECULAR CLONING OF HUMAN NEUROTROPHIN-4 GENE

Ｎｅｕｒｏｔｒｏｐｈｉｎ 4 (ＮＴ 4 )ｉｓａｍｅｍｂｅｒｏｆｈｅｎｅｕ ｒｏｔｒｏｐｈｉｎｆａｍｉｌｙｏｆｓｔｒｕｃｔｕｒａｌｌｙｒｅｌａｔｅｄ ｐｒｏｔｅｉｎｓ[1] ,ｔｈａｔａｌｓｏｉｎｃｌｕｄｅｓｎｅｕｒｏｔｒｏｐｈｉｎ 3(ＮＴ 3) ,ｎｅｕ ｒｏｔｒｏｐｈｉｎ 6 (ＮＴ 6 ) ,ｎｅｒｖｅｇｒｏｗｔｈｆａｃｔｏｒ (ＮＧＦ)ａｎｄｂｒａｉｎ ｄｅｉｖｅｄｎｅｕｒｏｔｒｏｐｈｉｃｆａｃｔｏｒ (ＢＤＮＦ) [2 - 6] ,ｗｈｉｃｈｓｕｐｐｏｒｔｓｔｈｅｓｕｒｖｉｖａｌｏｆｖｅｒｔｅｂｒａｔｅｎｅｕｒｏｎｓ[7] .Ａｔｐｒｅ…     

THE ADAPTABLE CHANGE OF THE FUNCTION OF T LYMPHOCYTES FOR PHYSICAL EXERCISE WITH OXYGEN

T lymphocytes are the main immunocytes withactivity and the degree of the activity can directlyaffect the immunity of human bodies. At the sametime, because the lymphocytes are the most sensi-tive cells to physical exercise, many specialistshave paid more attention to the research on it.Many previous researches have proved that physi-cal exercise could induce the of increasing numberof leukocyte in cycle, especially the number ofmonocytes and the degree of the increase is relatedto the amount …