Establishment of a uremic apolipoprotein E knockout mouse model to explore the mechanism of uremic atherosclerosis

Objective To establish a uremic apoE-/- mouse model to observe serum biochemical parameters and features of aortic root atherosclerosis (AS) in the model. Methods A uremic model was induced surgically in apoE-/- mice: electrocautery of the right kidney at 8 weeks of age and nephrectomy (NX) of the left one 2 weeks later. Control mice were sham-operated. Two weeks after NX, renal functions were detected in the uremic and control mice to evaluate the efficiency of the model. After 10 weeks of NX, blood samples were taken to determine serum biochemical parameters, and aortic root was collected for frozen sections to investigate the lesion features of AS. Results Two weeks after NX, renal functions declined significantly in the uremic mice compared with the control ones, and remained stable 8 weeks later either in males or in females. Ten weeks after NX, serum levels of TCH, TG and LDL-C were dramatically higher in the uremic mice than in the controls, whereas no differences in serum HDL-C or glucose concentration were found between the two groups. Aortic root plaque relative area increased significantly in the uremic mice compared with the controls either in males or in females; more-over, the lesion area was larger in female mice than in male ones. Conclusion We established a uremic apoE-/- mouse model successfully, and this model is characterized by accelerated atherogenesis which is associated with an increase in serum lipid profile. This experimental model can be a useful tool to study the pathogenesis and therapeutic strategies of uremic AS.     

城市轨道交通电动列车司机值乘方案的优化

以上海轨道交通3号线为例,对电动列车司机值乘的包乘制、轮乘制按实际效果和使用成本进行了优缺点分析;并在此基础上对司机作息安排、人员配置、运作管理情况综合进行优化,以期达到网络运营后节约人力成本的作用.     

山区公路路基排水系统灾害评价体系研究

对公路路基排水设施调查，提出山区高速公路排水设施水毁灾害形式，存在水毁频率最高的“三关键”水力学问题。确定公路排水设施水毁评价。四层次”评价指标体系，建立了将递进的“四层次”过程评价与层次系统模糊评价结合、水毁敏感点评价与排水系统评价结合的方法。提出了排水系统孕灾环境危险性、易损性评价具体的指标体系，水毁经济价值与工程防治措施效益计算方法，及小桥涵敏感点抗水毁具体评价指标体系。     

Load-leveling suspension system with a magnetorheological damper

In this paper, a load-leveling suspension system with a magnetorheological (MR) damper is investigated. In this suspension system, the MR damper is connected to a spring to form a load-leveling suspension system. The system effective stiffness and damping can be adjusted by controlling the MR damper. The characteristics of a load-leveling suspension system are studied first. When the linear damper is replaced with an MR damper, the averaging method is adopted to obtain the steady-state response of the nonlinear system. A comparison demonstrates that the results of the averaging method are in good agreement with those obtained by numerical simulations. The analytical results are then verified experimentally. The load-leveling suspension system studied here is able to adjust both suspension stiffness and damping and, hence, it may provide more effective vibration control in a wider frequency range, when the damper is controlled.     

桥梁静动载试验检测方法

我国近年来公路桥梁建设发展迅猛,而质量是公路桥梁建设的永恒的主题。该文综述了桥梁静动载试验检测方法,及其主要工作内容和发展方向。     

含砂低液限粉土路基冲击压实技术研究

针对含砂低液限粉土路用性能差,常规压实方法难以达到压实度要求等施工难题,采用冲击碾压技术进行路基补压试验,获取冲压遍数、冲压沉降量等施工控制参数。通过试验确定采用沉降与面波法进行冲压质量评价,为全线推广使用冲击压实技术提供技术保障。     

关于CTCS-2级列控系统应急预案的探讨

阐述了CTCS-2级列控系统设备故障后，司机、车站值班员、列车调度员、电务值班员、电务段调度等应如何处理，提出了CTCS-2级列控系统满足动车组安全运行不间断应急处理的总原则。     

管幕内顶进箱涵时顶部管幕力学作用的试验研究

上海市中环线虹许路北虹路下立交工程是目前世界上在饱和含水软土地层中施工的横截面最大的管幕法工程。为了充分研究箱涵顶进过程中管幕的力学作用,根据相似理论,按照实际工程状况进行了室内模型试验,得到了箱涵推进过程中地面和顶部管幕的竖向位移,以及管幕下土压力的变化特征,发现箱涵前端一定范围内的地层主要表现为竖向沉降变形,顶部管幕在箱涵推进过程中起到一定的承载作用,这对于稳定箱涵前端开挖面是有利的。试验结果对实际工程的设计与施工提供了一定的参考。     

湿陷性黄土路基常见病害及防治措施

湿陷性黄土遇水浸湿时， 土的强度显著降低， 对工程造成的危害性很大。 文章通过介绍湿陷性黄土的结构组成及其分类评价， 分析了其产生常见病害及成因， 从设计和施工方面提出了相应的防治措施， 为今后实际工程的设计和施工提供一定的指导和借鉴意义。