A NEW SYSTEM DYNAMIC EXTREMUM SELF-SEARCHING METHOD BASED ON CORRELATION ANALYSIS

Inindustrialprocessesself searchingoptimumcontrolsystemshavebeenwidelyused ,becausetheydonotneedamathematicalmodel,whichhaveblockdiagram (seeFig .1) .Theprincipleistomakethecontrolsystemreachitsoptimumoperatingstatebycontinuousmeasuringandcontrolling.Thenec essaryconditionisthattheplantsmusthaveanex tremumcharacteristic[1 ] .Thekeyofself searchingoptimumcontrolishowtofindthesystemextremum pointautomati cally .Therearemainlytwokindsofself searchingmethods,whicharethecontinuoussearchingandthest…     

血清CPK、LDH、GOT和LAP活性对急性颅脑损伤的诊断价值

对８０例急性颅脑损伤患者血清ＣＰＫ、ＬＤＨ、ＧＯＴ和ＬＡＰ活性进行了测定。结果显示，急性颅脑损伤后血清ＣＰＫ和ＬＤＨ活性显著升高（Ｐ＜０．０５），而血清ＧＯＴ和ＬＡＰＩ活性升高不明显（Ｐ＞０．０５），至于血清酶活性对判断急性颅脑损伤的脑损伤程度和患者预后的价值有待继续探讨。     

X线引导下的骨骼活检

作者用20~#～23~#穿刺针改制的针芯,尖端呈三棱形、针管为“Z”型切口的骨穿刺针,在X线引导下对200例各种骨疾病进行了穿刺活检。本组未出现并发症,该穿刺针适用于除努椎病变外的各种骨疾病检查。X线引导下的骨骼活检是一种安全、有效的诊断和鉴别诊断方法。     

基于满意优化的模糊多目标预测控制算法研究

提出了以满意优化取代传统的最优控制对模糊预测控制中的性能指标进行优化的方法。以模糊多目标单步预测模型为例，给出了系统对某一控制目标的满意优化控制算法，并在此基础上提出了基于满意优化的模糊多目标预测控制算法。     

小鼠前胃癌前病变阻断实验及分子学机制的变化

目的　维甲酸阻断小鼠前胃癌前病变模型 ,观察表皮生长因子受体 (EGFR)、细胞周期素D(CyclinD1)、血管内皮生长因子 (VEGF)在小鼠前胃癌变阻断前后的变化规律。方法　将 10 0只ICR雌性小鼠随机分为 3组 :A组(40只 )用诱癌剂诱导 ;B组 (40只 )在第 6周停用诱癌剂后继续灌喂维甲酸 ;C组 (2 0只 )仅服用等量的生理盐水。实验第 77天将小鼠全部处死 ,取前胃组织切片 ,免疫组化染色。结果　B组癌前病变发生率及癌总发生率均较A组明显降低。EGFR、CyclinD1、VEGF在癌变上皮的表达与组织学分级有关。A、B两组EGFR、CyclinD1、VEGF在癌前病变中表达强度与组别无关。VEGF的表达强度随着EGFR的增加而增强 ,而CyClinD1与EGFR、VEGF表达强度无关。结论　EGFR、CyClinD1、VEGF与癌肿的发生密切相关 ,而表达程度与组织学分级关系不大。在癌变过程中EGFR和VEGF有协同作用。维甲酸可降低VEGF的表达水平 ,对小鼠前胃癌前病变有明显的阻断作用。     

论中国土地资本化中的利益分配问题

中国有关土地问题社会矛盾产生的前提，是土地资本化的必然趋势；产生的经济基础，是土地资本化中的利益分配格局。这种分配显示了利益向开发商倾斜的格局。构成这种格局的根源，是中国特殊的“内公外私”产权制度，以及经济起飞阶段普遍存在的产业资本稀缺性。在特定历史阶段形成这种利益分配格局是必然的，从一定意义上来说也是合理的。此外，从来不存在“起点公平”的分配。     

IMPLEMENTATION OF GRADIENT-BASED ESTIMATION OF HMM PARAMETERS

IntroductionIn Hidden Markov Model ( HMM) - basedspeech recognition systems,it is very importanttoset the parameters of HMMs correctly.Conven-tional training algorithms such as Baum- Welch al-gorithm,are based on the criterion of maximumlikelihood( ML) .The strength of Baum- Welch al-gorithm lies in its fast convergence andmonotonous improvement[1] . For other criteriasuch as maximum mutual information,however,such an algorithm does not exist.In this case,acommon resort is a gradient- b…     

CORRELATIONS BETWEEN BLOOD PRESSURE AND BODY WEIGHT, SERUM LEPTIN IN HIGH CALORIE DIET-INDUCED OBESE RATS

Objective To examine the change of body weight （BW） and blood pressure （BP） in obese rats, clarify relationships between BP and BW and other factors. Methods Male Spraque-Dawley rats were fed either with normal diet （ND） or high calorie diet （HC） for 20 weeks. BW and BP of tail artery were observed biweekly and tetraweekly respectively; serum leptin and fasting insulin （FINS） were detected by enzyme-linked immunoadsordent assay （ELISA） and radioimmunoassay （RIA） respectively. Fasting plasma glucose （FPG） and free fatty acid（FFA） were measured by conventional means. Results BW, abdominal fat weight （AFW）, ratio of abdominal fat weight to body weight （RF/W）, systolic blood pressure （SBP）, diastolic blood pressure （DBP）, serum levels of leptin and FINS, FPG, FFA increased in the HD group after 20 weeks diet intervention （P〈0.05 or P〈0.01 ）. SBP was strongly correlated with BW, leptin, FINS and FFA （P〈0.05）, DBP was correlated with FFA （ r =0.47, P〈0.05）. In addition, leptin was positively correlated with BW, AFW, RF/W, FINS and FFA （P〈0.05 or P〈0.01 ）. Conclusion In this study of high calorie-diet induced rats, the gain of BW is accompanied by increased BP. The obese rats have hyperleptinemia, hyperinsulinemia, hyperglycemia and dyslipidemia which may have important effects on the development of obesityrelated hypertension. RF/W is the key factor in which affect serum leptin level.     

基于效益机制的分局调度货运日计划优化模型

在效益机制下进行货运日计划优化的目的是，在有限的运输资源条件下，使日计划实现运输效益最大化．在分析车站能力、空车供应、限制口能力和分界口交接等诸多运输约束的基础上，通过对运输约束准确的数学描述，建立了以运输效益最大为目标函数、以运输限制为约束的优化模型。     

The β-amyloid protein induces S100β expression in rat hippocampus through a mechanism that involves IL-1

Objective To explore the effect of β-amyloid protein (Aβ) on S100β expression in rat hippocampus and its mechanisms. Methods At 7 days after bilateral stereotaxis injection of different dose of fibrillar Aβ 25-35 and interluekin-1 receptor antagonist (IL-1ra) into the rat CA1 region, the learning and memory abilities of rats were tested with passive avoidance task. Amyloid deposition was detected by using Congo red staining technique. Nissl staining and immunohistochemical techniques were used to analyze the number of neurons, and GFAP and the S100β expression in hippocampal CA1 region , respectively. Results After fibrillar Aβ injection, the step-through latency of rats was significantly shortened compared to that of the control group. The GFAP positive astrocytes were found surrounding amyloid deposition. Neuronal loss occurred in the pyramidal cell layer of CA1 region. The number of S100β positive cells in Aβ-treated group was significantly increased compared with that in the control group. After IL-1ra injection, the number of S100β positive cells was significantly decreased. Conclusion Intrahippocampal injection of Aβ 25-35 could cause similar pathologic changes of Alzheimer's disease. Aβ 25-35 was capable of up-regulating S100β expression in a dose-dependent manner. The injection of IL-1ra could attenuate the effect of Aβ on S100β expression.