综合重症监护病房患者呼吸机相关性肺炎的病原学和耐药性分析

目的探讨病原菌在综合重症监护病房(ICU)患者呼吸机相关性肺炎(VAP)中的分布及对常用抗生素的耐药情况。方法对我院2004-2006年综合ICU患者VAP病原菌的分布及耐药性进行回顾性统计分析。结果从302例综合ICU VAP患者下呼吸道深部分泌物标本中分离出347株病原菌,主要病原菌是铜绿假单胞菌(32.3%)、鲍曼不动杆菌(31.1%)、金黄色葡萄球菌(16.7%)、克雷伯菌(7.5%)与凝固酶阴性葡萄球菌(6.1%)。革兰阴性杆菌(G-杆菌)对哌拉西林、头孢噻肟耐药率最高,对碳青霉烯类及加酶抑制剂抗生素耐药率最低;革兰阳性球菌(G 球菌)对青霉素类、克林霉素及红霉素耐药率高,对万古霉素、喹诺酮类抗生素耐药率低。结论G-杆菌是综合ICU患者VAP最主要的病原菌,多重耐药性高;耐甲氧西林金黄色葡萄球菌(MRSA)和耐甲氧西林凝固酶阴性葡萄球菌(MR-SCNS)的分离率高且耐药严重。临床医师应根据病原菌学及抗菌药物敏感性资料,及时选择合理的抗生素控制感染,延缓耐药菌株的产生。     

番茄红素预防高脂喂饲大鼠脂质代谢紊乱的作用及机制探讨

目的探讨番茄红素对高脂喂饲大鼠脂代谢紊乱的作用及机制。方法用高脂饲料喂养大鼠,同时给予番茄红素灌胃,检测体重、血脂和肝组织脂质水平及肝组织的病理学变化,探讨可能的减肥机制。结果番茄红素可显著降低大鼠血清中胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平及动脉粥样硬化指数(AI)(P<0.05),适当升高高密度脂蛋白胆固醇(HDL-C)水平;番茄红素中、高剂量组明显降低肝组织中TC、TG、LDL-C含量(P<0.05),中剂量组明显提高HDL-C水平(P<0.01)。病理观察显示,番茄红素各剂量组脂肪变性及肝细胞肿胀程度减轻,接近正常水平。结论番茄红素具有预防高脂饲料喂饲大鼠血清和肝组织脂代谢紊乱的作用,其机制可能是促进HDL-C合成,减少TC、TG、LDL-C在体内的蓄积。     

勘察设计企业成本核算工作探究

结合勘察设计企业项目成本核算的特点,阐述了做好项目成本核算的意义、项目成本核算的实施。并对项目成本进行分析,针对其存在的问题,提出相关改进建议。     

Development of analytical procedure for selection of control measures to reduce congestions at various freeway bottlenecks

Variable speed limit (VSL) and ramp metering (RM) affect freeway traffic operations in different ways and, accordingly, result in different effects on system travel time. The primary objective of this study is to propose an analytical procedure to help determine which control measure should be selected given different freeway bottlenecks and traffic conditions. The bottlenecks considered included an isolated merge bottleneck, a merge bottleneck with a closely spaced upstream off-ramp, and a diverge bottleneck with a closely spaced upstream on-ramp. Two RM and a VSL control strategies were considered, including the ALINEA, ALINEA/Q and feedback based VSL. The maximum achievable improvements in system efficiency by various control measures were calculated and the results were tested using modified cell transmission models. A coordinated control strategy that combined ALINEA/Q and VSL control was also proposed. The effects of VSL and RM control on system travel time at different freeway bottleneck areas were compared to identify the applicable conditions of different control measures. The analytical procedure was proposed for the selection of control measures at different bottlenecks and the ex-ante estimation of control effects were also discussed.     

川藏铁路某隧道不明气体成因机制研究

为解决复杂地质条件地区隧道工程建设中出现的不明气体问题,以川藏铁路某隧道出现不明气体为切入点,结合工程地质学、地球化学等学科交叉的研究方法与思路,对该不明气体的成因机制及演化特征进行研究,探索一种研究不明气体的新思路。基于现场采样测试与全天候监测,总结分析该不明气体成分特征及其演化规律,得出该不明气体为混合成因气体;同时,从不明气体的工程地质条件入手,着眼于区域油气资源和煤系地层的分布及区域地质构造、岩石裂隙发育情况,排除不明气体由其他地区运移而来的可能;在此基础上,进行岩石室内试验,通过对不明气体赋存环境进行地球化学分析,分别论证气体的有机成因及无机成因,得出该不明气体是原地产生的,经历了有机成因和无机成因2个阶段且储量有限,对工程后期影响不大,为隧道后期顺利施工提供了指导。     

Numerical Analysis of the Mixture Formation in a Two-Stroke Wall-Guided LPG DI Engine for Extended-Range Electric Vehicle

The use of automotive LPG characteristics which are easy to evaporate vaporization and carry. The paper presents a design of extended-range electric vehicle for wall-guided two stroke LPG engine with direct injection combustion system. Based on the modified vehicle LPG spray model, a database describing the characteristics of vehicle LPG fuel was built and imported into the CFD software. And the accuracy of the model is verified by the Schlieren experimental results. The concentration and velocity field of the mixture in the cylinder under different load conditions are numerically analyzed. The analyzed result indicated that the start injection time θ = 60°–70°CA BTDC under part load condition, the plug electrode near the gathering of a richer mixture is easy to be fired at spark ignition time, the obvious formation of mixture in cylinder is formed and the overall air-fuel ratio is above 40: 1. The start-transition working condition and large load conditions in the piston moves upward before closing the exhaust port to start injection LPG. The optimized LPG injection start time θ ensures that the fresh gas is locked in the cylinder when the exhaust port is closed (63°CA ABDC). In the ignition time of the spark plug, an ideal homogeneous mixture in the cylinder is realized.     

Tire wear estimation based on nonlinear lateral dynamic of multi-axle steering vehicle

This paper presents a novel nonlinear dynamic model of a multi-axle steering vehicle to estimate the lateral wear amount of tires. Firstly, a 3DOF nonlinear vehicle dynamic model is developed, including dynamic models of the hydropneumatic suspension, tire, steering system and toe angle. The tire lateral wear model is then built and integrated into the developed vehicle model. Based on the comparison of experimental and simulation results, the nonlinear model is proved to be better than a linear model for the tire wear calculation. In addition, the effects of different initial toe angles on tire wear are analyzed. As simulation results shown, the impact of the dynamic toe angle on the tire wear is significant. The tire wear amount will be much larger than that caused by normal wear if the initial toe angle increases to 1° - 1.5°. The results also suggest that the proposed nonlinear model is of great importance in the design and optimazation of vehicle parameters in order to reduce the tire wear.     

双十字轴万向节转向系统力矩波动的优化设计

汽车转向力是汽车操纵稳定性评价中的重要指标,转向力的力矩波动直接影响着驾驶感受,合理的相位角设计能够有效地减少力矩波动。本文阐述了转向系统力矩波动原理,并运用该方法进行了某车型转向系统的优化设计。     

基于山区复杂路段下的车辆主动限速控制系统研究

山区复杂路段交通事故频发,行车安全问题亟待解决,因此研究该路段下的主动限速控制技术具有重要意义。本文阐述了主动限速控制系统的原理与构成,并且对车辆的运行安全车速进行了分析与建模,提出了主动限速的控制策略。最后通过对该系统软硬件进行了调试,初步验证了其可行性比较合理,能够指导驾驶人的行车安全。     

SCR技术原理探讨

文章介绍车辆排放后处理系统-SCR(发动机排气催化净化技术)技术发展必要性及SCR技术原理。本篇文章是对SCR的一个基本介绍,SCR系统会随着车辆及发动机在硬、软件上配置的变化而发生改变。