替加色罗对结肠炎大鼠内脏敏感性的影响及其与结肠内P物质和降钙素基因相关肽表达的关系

目的评价替加色罗对结肠炎大鼠内脏敏感性的影响,并探讨其调节内脏敏感性的作用途径。方法成年雄性SD大鼠42只,经三硝基苯磺酸(TNBS)灌肠诱导结肠炎后随机分为4个实验组和4个对照组:其中3个结-直肠扩张(CRD)实验组(n=6)及3个CRD对照组(n=4)分别给大鼠替加色罗和生理盐水灌胃,在灌胃3、7、14 d后记录腹壁肌电活动;1个免疫组化(IH)实验组(n=6)及其对照组(n=6)分别在替加色罗和生理盐水灌胃7d后,采用免疫组织化学法观察大鼠结肠内P物质(SP)和降钙素基因相关肽(CGRP)的表达。结果替加色罗灌胃3 d后,在1.2、1.6mL扩张容量下,大鼠腹肌收缩次数(6.00±1.10,3.17±0.98)较对照组明显减少(9.50±2.52,13.0±2.31,P<0.05)。替加色罗连续灌胃7 d和14 d后,在0.4、0.8、1.2、1.6 mL扩张容量下,大鼠腹肌收缩次数均明显少于对照组(P<0.01)。替加色罗灌胃7 d后,结肠内SP染色评分下降,而CGRP染色强度与对照组比较无明显变化。结论替加色罗可以明显降低结肠炎大鼠对结肠球囊扩张刺激的敏感性,其降低内脏敏感性的作用可能与其抑制胃肠道内脏感觉传入神经表达SP有关。     

雾封层技术在沥青路面预防性养护中的应用

结合雾封层预防性养护技术在桥面铺装层的应用,探讨了雾封层技术的适应性、施工工艺及质量控制要点。采用雾封层后,经检测表明减少了路面的水损坏,延长了道路的使用寿命,取得了较好的效果,可为其他类似工程提供借鉴。     

Direct resolution of the pitch of DNA on positively charged lipid bilayers by frequency-modulation AFM

High resolution structural studies of DNA and DNA binding proteins by atomic force microscopy (AFM) require well-bound samples on suitably flat substrates. Adsorbing the DNA onto a positively charged supported lipid bilayer has previously been shown to be a potentially effective strategy for structural studies with AFM. Here, using our home-built frequency-modulation AFM (FM-AFM), we show that these bilayer substrates are only maximally effective for high resolution AFM when the samples are short, linear DNA, compared with circular plasmid DNA. We find that, with the former sample, the measured width of the DNA is about 2 nm, the known DNA diameter, and there is a clear height modulation along the length of the DNA with a periodicity of about 3.4 nm, in excellent agreement with the known pitch of the double helix. This sample preparation strategy is expected to enable higher resolution studies of DNA and DNA binding proteins with FM-AFM than that can presently be achieved.     

关于静电场电势零点选取的探讨

电势是物理学中一个重要的概念,从理论上讲,在计算电势时,电势零点的选取是任意的,然而在有些情况下,电势零点的选取却是受限制的,本文将探讨如何选取合适的电势零点。     

失速点上湿压缩对于跨音速压气机转子性能的影响

In order to study the effects of wet compression on a transonic compressor,a full 3-D steady numerical simulation was carried out under varying conditions.Different injected water flow rates and droplet diameters were considered.The effect of wet compression on the shock,separated flow,pressure ratio,and efficiency was investigated.Additionally,the effect of wet compression on the tip clearance when the compressor runs in the near-stall and stall situations was emphasized.Analysis of the results shows that the range of stable operation is extended,and that the pressure ratio and inlet air flow rate are also increased at the near-stall point.In addition,it seems that there is an optimum size of the droplet diameter.     

大跨刚架拱桥病害分析及加固研究

在对某座刚架拱桥进行安全检测的现场发现主拱大节点裂缝、横向联系梁破坏等病害。该文根据现场检测结果,分析了刚架拱桥常见病害形式及产生原因。采用BCI评价对该桥进行整体技术状况进行评定,并根据评定结果针对性地提出了对刚架拱桥加固的建议。其检测结果、建议加固措施对同类拱桥病害处理具有借鉴意义。     

铁路产品认证的一致性检查和检验

介绍铁路产品认证一致性的要求及涉及范围，阐述铁路产品认证的一致性检查和检验的范围及方法。     

自动进路原理中触发时刻的最优化分析

首先分析了进路触发时刻对自动进路以及运营效率的影响,然后本着运营效率最大化的原则,针对三种不同的信号布局,详细阐述了进路触发时刻的最优测算原则,最后对自动进路功能在复杂情况下的综合应用进行了分析。     

Fe—21Ni—4Mn合金磁场诱发马氏体形貌和惯习面

本文采用强脉冲磁场、光学显微镜和 H.R.Pak 等提出的惯习面确定方法研究了 Fc-21Ni-4Mn 合金中磁场诱发马氏体形貌和惯习面.结果表明,Fe-21Nj-4Mn 合金冷却形成板条马氏体,而在 Ms 温度以上,磁场诱发形成多片状而少板条马氏体,且随温度升高,磁场诱发马氏体形貌为蝶状.磁场诱发马氏体惯习面与冷却形成的马氏体相同,均为(225),对于蝶状马氏体发现了一种新的对称面(110).     

214国道云南段高边坡稳定性分析

214国道云南段存在大量路堑高边坡，因边坡地质环境十分脆弱，岩体边坡普遍较破碎，土质边坡降雨入渗后，使工程开挖施工中大量边坡失稳。结合工程实践，总结了不同类型边坡稳定情况，并应用数值计算进行了验证。