LIGUSTRAZINE REDUCES CARTILAGE DESTRUCTION IN MODEL OF OSTEOARTHRITIS IN RATS

Objective To study the effect and possible mechanism of Ligustrazine-a chinese traditional herbal medicine (CTM) on rat osteoarthritis (OA). Methods OA model was surgically induced. Morphology of articular cartilage was done by HE staining and mankin score was calculated; interleukin-1 and TNFα activity of rat joints was determined by 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method; immunohistochemistry of MMP-13 and Cathepsin K was done by ABC method while the mRNA level for MMP-13, cathepsin K and tissue inhibitor of matrix metalloproteinase 1 (TIMP-1) was evaluated by RT-PCR method. ResultsLigustrazine (60 mg·kg-1·d-1 or 30 mg·kg-1·d-1, but not 10 mg·kg-1·d-1, im, ×8 weeks) reduced morphological changes of articular cartilage of OA rats. IL-1 and TNFα production of OA joints increases, together with MMP-13, cathepsine K and their mRNA levels in articular cartilage. The administration of Ligustrazine (60 mg·kg-1·d-1or 30 mg·kg-1·d-1, im, ×8 weeks) reduced above changes significantly. At the same time, tissue inhibitor of metrix metalloprotease (TIMP1) mRNA level increased also in OA rats while Ligustrazine (60 mg·kg-1·d-1, 30 mg·kg-1·d-1or 10 mg·kg-1·d-1, im, ×8 weeks) had no significant effect on it. Conclusion Ligustrazine (60 mg.kg-1 d-1 or 30 mg·kg-1·d-1, but not 10 mg·kg-1·d-1, im, ×8 weeks) effectively delays articular cartilage degradation of OA rats and could be a potential drug candidate for OA treatment.     

船用柴油机气缸套穴蚀的成因及其预防措施

文章介绍了船用柴油机气缸套穴蚀的现象,分析了穴蚀的成因机理,提出了提高气缸套抗穴蚀能力的一些具体措施,并对船用柴油机气缸套的设计、制造与维修提出一些建议,以延长气缸套的使用寿命。     

政府主导下公铁联运系统三方演化博弈研究

公铁联运作为一种节能高效的运输模式亟需在我国发展.本文从系统角度出发,构建政府与公铁运输企业的三方博弈模型,通过博弈稳定性分析得到公铁联运系统满足稳定性条件的7个均衡点.运用数值仿真研究公铁联运系统理想策略集演化路径,阐明公铁联运系统内各主体演化趋势内在机理.分析各主体初始策略意愿变化下系统的演化趋势,发现公铁运输企业...     

Study on Real-time Look-ahead and Adaptive Parametric Curve Interpolator

The principle of real-time look-ahead was introduced and analysed. An adaptive parametric curve interpolator with a real-time look-ahead function was developed for non-uniform rational B-spline (NURBS) curves interpolation, which considering the maximum acceleration/deceleration of the machine tool. In order to deal with the acceleration/deceleration around the feedrate sensitive corners, the look-ahead function was designed and illustrated. It can detect and adjust the feedrate adaptively. With the help of real-time look-ahead, the acceleration/deceleration can be limited to the range of the machine tool capacity. Thus, feedrate fluctuation is reduced. A NURBS curve interpolation experiment was provided to verify the feasibility and advantages of the proposed interpolator with a real-time look-ahead function.     

Study and Development of the Biped Ice Skating Robot with Passive Wheels

A new passive wheel type of biped ice-skating robot(BISR)which was able to imitate human skating motion was developed. Firstly, the characteristics of two types of human skating gait were introduced; secondly, after simplifying the kinematical model, the BISR's motion principle was presented; then the construction and control system of BISR were proposed; at last, the skating experiment of the BISR in a symmetric gait mode was conducted and some conclusions were drawn.     

计及需求侧的风-光-氢多能互补微电网优化配置

针对多能互补微电网经济成本最优问题,提出一种计及需求侧响应的风-光-氢多能互补微电网优化配置方法.首先,在相关功率约束和控制原则下制定运行控制策略;接着,为最大化直接消纳风光发电,引入激励型需求侧响应,利用混合整数规划优化负荷曲线;进而,建立考虑需求侧响应的优化配置模型,基于等年值成本最小的优化目标,综合考虑系统的必要...     

高速铁路对湖南省县域经济集散效应分析

为研究高速铁路对湖南省县域经济集散效应,选取2008～2017年湖南省124个区县的数据,采用双重差分(Difference in Difference,DID)模型,从经济密度、人口密度、第三产业区位熵、市场内部潜力4个方面来衡量高铁开通对县域经济产生的影响.研究结果表明:高速铁路开通对湖南高速铁路通过的核心县城市人...     

高速交通对区域发展的影响机理与调控策略

为讨论高速交通对区域发展的影响机理,在分析影响因素的基础上,以山东省高速交通建设对17个市级区域经济的影响情况为研究对象,使用面板数据模型构建指标体系.结果表明:高速交通建设会对区域经济产生较大促进作用,其中高速公路拟合系数最高,对区域经济及劳动力就业影响较大;通过对比高速铁路修建前后经济数据变化,得出高速铁路的修建对区域发展不仅具有促进作用、还能吸引大量劳动力的结论.总体看,高速交通建设对山东省17个地市的区域发展有显著影响.最后,从宏观与微观两方面提出相关调控策略,为政府和区域优化二者关系提供参考.     

基于改进密度聚类算法的交通事故地点聚类研究

交通事故特征受地域分布影响显著,本文对交通事故特征进行优化聚类研究.基于 2019年无锡市交通事故数据,调用开放地图接口地理编码解算事故地点经纬度,使用密度聚类算法对事故地点与事故原因进行密度聚类.传统的密度聚类算法依赖距离阈值和样本数阈值的准确输入,为解决这一局限,建立一种自适应搜索距离阈值和样本数阈值的密度聚类模型,并与原始聚类模型进行对比.结果表明,优化算法在参数确定上更加智能,对簇的划分更加准确,对噪声点的识别更加合理.通过机器学习中轮廓系数计算方法计算模型得分,证明了该算法在城市道路交通事故地理位置聚类中的适用性.     

数据驱动跟驰模型综述

车辆跟驰模型是被交通科学与交通工程领域广泛认可的微观交通流模型,是交通流理论 的基础。近年来,信息感知与获取、大数据、人工智能等技术快速发展,推动了数据驱动跟驰模型 的快速发展。数据驱动跟驰模型,是以真实的车辆行驶数据为基础,利用数据科学与机器学习等 理论和方法,通过样本数据的训练、学习、迭代、进化,挖掘车辆跟驰行为的内在规律。本文系统 回顾了数据驱动跟驰模型在过去20余年的发展历程以及由神经网络和深度学习带动的两次研究 热潮,归纳了基于传统机器学习理论的跟驰模型、基于深度学习的跟驰模型、模型与数据混合驱 动的跟驰模型3类数据驱动跟驰模型,并分别介绍了其中的典型代表。分析数据源发现,尽管各 种高精度轨迹数据不断涌现,目前研究仍多使用美国于2006年发布的Next Generation Simulation (NGSIM)高精度车辆轨迹数据,模型的可移植性和泛化能力值得思考与研究。提出关于模型输 入、输出的3个问题：如何考虑更多驾驶行为变量,是否有必要考虑更多行为变量,现有输入、输出 是否可替换。在模型测试与验证方面,发现并讨论了目前测试不充分、对比不完整、缺少统一测 试集与测试标准等问题。最后,探讨了数据驱动跟驰模型原创性与成功的关键因素等问题。期 望通过本文的梳理,帮助研究者更好地了解数据驱动跟驰模型的过去与现状,促进相关研究的快 速发展。