siRNA AGAINST SURVIVIN SUPPRESSES THE PROLIFERATION OF PANCREATIC CANCER CELL PC-2 AND INDUCES ITS APOPTOSIS

Survivinis a member of the inhibitor of apop-tosis family,whichinhibits cell apoptosis and regu-lates cell division.Survivin is expressed in embry-onic tissues as well as in the majority of humancancers,but is not expressed in most nor mal adulttissues.The highly cancer-specific expression ofSurvivin,coupled withits i mportance in inhibitingcell apoptosis and in regulating cell division,makesit a useful diagnostic marker and ideal target forcancer treat ment[1].RNAi is a process of post trans…     

ROLE OF PERIPHERAL LYMPHOCYTES SIALYL LEWIS（X） （CD15s） ANTIGEN BEFORE AND AFTER KIDNEY TRANSPLANTATION

Objective To investigate the role of peripheral lymphocytes Sialyl Lewis（x） （CD15s） antigen before and after kidney transplantation. Methods Flow cytometry technique was applied to examine the expression of peripheral lymphoid cell surface CD15s antigen after renal transplantation, and to evaluate various therapeutic regimen. Results The statistic analysis results of peripheral lymphoid cell surface CD15s antigen expression level showed that there was significant difference among the patients with acute rejection, long-term dialysis and with normal renal function post-transplant; significant difference of CD15s expression level between group of rejection and infection; no significant difference of CD15s expression among the different groups treated by various therapeutic regimens. Conclusion The different therapeutic regimen has no influence to CD15s expression; Detection of peripheral lymphoid cell surface CD15s antigen expression periodically, intelligently make convenience to understand suitable status of immunosuppression.     

An Experimental Study on the Drag Property of High Temperature Particles Falling into Cold Liquid Pool

This experiment is to study the special resistant induced by the high-speed evaporation surrounding the moving high-temperature particles. An observable equipment was designed, in which the first 11 experiments were performed by pouring one or several Zirconia spheres with various high-temperature and a diameter of 3-10mm into a water pool. The particles falling-down speeds were recorded by high-speed photographic instrumentation,and pressures and water temperatures were measured. A comparison between the experiments with cold and hot spheres respectively, employing three different sphere types each, was presented. The experimental data, com-pared with the theory of the evaporation drag model, are nearly identical.     

CLASSIFICATIONS OF EEG SIGNALS FOR MENTAL TASKS USING ADAPTIVE RBF NETWORK

Objective This paper presents classifications of mental tasks based on EEG signals using an adaptive Radial Basis Function (RBF) network with optimal centers and widths for the Brain-Computer Interface (BCI) schemes. Methods Initial centers and widths of the network are selected by a cluster estimation method based on the distribution of the training set. Using a conjugate gradient descent method, they are optimized during training phase according to a regularized error function considering the influence of their changes to output values. Results The optimizing process improves the performance of RBF network, and its best cognition rate of three task pairs over four subjects achieves 87.0%. Moreover, this network runs fast due to the fewer hidden layer neurons. Conclusion The adaptive RBF network with optimal centers and widths has high recognition rate and runs fast. It may be a promising classifier for on-line BCI scheme.     

基于加速度计的无陀螺捷联惯性制导系统设计

针对舰炮武器系统射击精度低的问题,研究了适宜在炮弹中应用的基于微加速度计的无陀螺捷联惯性制导系统.采用三种方法对载体的角速度进行解算并分析了各种方法的利弊,提供了载体运动参数解算模型,通过仿真计算验证无陀螺方案的可行性,为惯性制导炮弹的发展提供了参考.     

SBS改性沥青混合料损伤模型分析

通过SBS改性沥青混合料的单轴拉伸试验,分析了粘弹性模型与损伤模型的特性,并耦合成粘弹性连续损伤模型;从能量的角度考虑了SBS改性沥青混合料的疲劳损伤特性和损伤效应,并建立了一种与拉伸应变水平相关的疲劳损伤模型。模型与试验吻合较好,可预测不同拉伸应变水平下SBS改性沥青混合料的疲劳寿命。     

离体毛囊切片两种制作方法的比较及凋亡检测

目的对人头皮游离毛囊(HF)切片制作及凋亡检测方法进行比较。方法分别将石蜡切片法和冰冻切片法应用于游离毛囊;利用原位缺口末端标记法(TUNEL)进行荧光染色与3,3′-二氨基联苯胺(DAB)染色,检测未经培养的游离毛囊及培养5 d的游离毛囊的不同部位凋亡细胞情况。结果在对游离毛囊形态检测中,各组毛囊在外根鞘(ORS),毛球(HB)下部,真皮鞘(DS)及毛乳头(DP)中的凋亡细胞数并无显著性差异(P>0.05)。结论冰冻切片法应用于游离毛囊简单有效,TUNEL原位荧光结合DAB染色适合于检测毛囊细胞凋亡情况。     

船与刚性桥墩的碰撞性能分析

运用非线性有限元基本理论，采用国际上广泛使用的大型结构分析程序LS—DYNA，建立了船舶、刚性桥墩的三维有限元计算模型．分析了碰撞力的大小、船首及构件的损伤和吸能特性，并与经验公式计算结果进行了比较，得出了有关船撞力大小和分布规律的结论．     

高强混凝土的试件强度及检验

分析了影响高强混凝土试件强度检测结果的主要因素,试件强度与构件混凝土强度的相关性;提出了构件混凝土强度检验中存在的问题和措施。     

重庆山区农村公路建设技术指标采用探讨

通过对重庆山区的农村公路实地调查、结合重庆地区地形、地质、以及经济状况,对重庆地区山区农村公路建设技术指标的采用进行探讨,并提出技术指标的采用应遵循的原则.