TSH RECEPTOR GENETIC ALTERATIONS IN THE AUTONOMOUSLYFUNCTIONING THYROID ADENOMAS

Objective To determine the relationship between TSH receptor gene mutations and autonomously functioning thyroid adenomas (AY‘]rAs). Methods The thyroid samples from 14 cases of diagnosed AFTAs were analyzed, with normal thyroid specimens adjacent to the tumors as controls. The 155 base pairs DNA fragments which encompassed the third cytoplasmic loop and the sixth transmembrane segments in the TSH receptor gene exon 10 were amplified by Polymerase chain reaction (PCR) and analyzed by the single-strand conformation polymorphism (SSCP). Direct sequencing of the PCR products was performed with Prism Dye Terminator Cycle Sequencing Core Kit.Results 6 of 14 AFTA specimens displayed abnormal migration in SSCP analysis. In sequence analysis of 3 abnormally migrated samples, one base substitution at nucleotide 1957 (A to C) and two same insertion mutations of one adenosine nucleotide between nucleotide 1972 and 1973 were identified. No mutations were found in controls. Conclusion This study confirmed the presence of TSH receptor gene mutations in AFTAs; both one-point substitution mutation and onebase insertion mutation were found to be responsible for the pathogenesis of AFTAs.     

EFFECTS OF FILTER MEMBRANES ADSORBING INFLAMMATORY MEDIATORS IN HEMOFILTRATION

Sepsisischaracterizedbyreleaseofexcessiveamountofproinflammatorycytokinesinthecircu lation ,leadingtoa generalizedanduncontrolledhostresponse .Aconsiderablenumberofexperimen talandclinicalinvestigatorshavereportedemploy inghemofiltration (HF)toeliminatecytokinesandchemokines .Thisexcessiveinflammatoryresponsecouldbedownregulatedwithremovalofcytokinesandothermediators .Thesedatashowedthatthemechanismofmediatorseliminationwaslinkedtoconvectionandadsorptionbyhemofiltration .Ad sorptionappearstob…     

计算机软件在沥青砼路面级配质量监督中的应用

在公路沥青混凝土路面配合比设计中,矿料配合比设计是一个重要环节。研究发现,通过使用计算机和Excel软件,在各种表格的单元格中设置相应计算公式、宏和绘图步骤,输入各种配合矿料的累计通过百分率后,通过简单的人机对话,完成各种矿料百分含量数据的输入和调整,自动生成各种图表;在质量监督中,通过现场检测混合矿料的级配,输入现场矿料、水泥混合累计通过百分率可自动判定其级配是否合格。     

A1-A1接头共晶接触反应钎焊的研究

本文研究了用Zn和Zn—Cu作中间夹层金属与Al形成共晶液相实现Al—Al接头的共晶反应钎焊。试验表明用Zn作中间夹层虽可与母材铝形成低熔点共晶液相,但由于对铝的强烈溶蚀作用,无法形成钎焊接头;在Al和Zn之间添加很薄的一层铜箔,可以防止Zn对Al的溶蚀,并与Zn、Al形成共晶液相,形成良好的钎焊接头。     

Fatigue damage calculation for oil tanker and container ship structures

The fatigue behaviour of longitudinal stiffeners of oil tankers and container ships, subjected to dynamic loads, is analysed. The following dynamic load components are considered: hull girder vertical wave bending moment, alone and combined with the horizontal wave bending moment, hydrodynamic pressure and inertial forces caused by cargo acceleration.

The spectral method was selected to calculate the fatigue damage, based on S—N curves and Miner's rule. Following this approach, the fatigue damage may be calculated as a function of a stress parameter Ω_p, which represents the cumulative effect of wave induced loads in the unit of time and incorporates the combined effects of stress level and its occurring frequency.

Simple formulas for Ω_p of oil tankers and container ships are given, obtained from the results of hydrodynamic analyses performed on several ships, in different wave environments.

Several examples show the applicability of the methods to real ship structures. The method, however, still needs to be calibrated because of the simplifying hypotheses introduced in the loading conditions.     

汽油/天然气汽车的燃料转换控制原理

介绍了汽油/天然气双燃料汽车的燃料转换控制原理,阐述了转换开关控制器逻辑控制单元的工作原理。     

A hybrid firefly algorithm for optimizing fractional proportional-integral-derivative controller in ship steering

In this paper, a new algorithm which integrates the powerful firefly algorithm(FA) and the ant colony optimization(ACO) has been used in tracking control of ship steering for optimization of fractional-order proportional-integral-derivative(FOPID) controller gains. Particle swarm optimization(PSO) algorithm is also used to optimize FOPID controllers, and their performances are compared. It is found that FA optimized FOPID controller gives better performance than others. Sensitivity analysis has been carried out to see the robustness of optimum FOPID gains obtained at nominal conditions to wide changes in system parameters, and the optimum FOPID gains need not be reset for wide changes in system parameters.     

城市轨道交通第三轨供电系统集电靴的力学性能试验研究

城市轨道交通第三轨供电系统集电靴的安装不仅关系着其自身设备的安全性,还影响城市轨道交通列车的供电质量,介绍了集电靴力学性能试验的传动和测试原理,确定了集电靴力学性能试验的方案。通过试验研究得到集电靴的静态刚度、等效阻尼等参数,为集电靴力学模型的建立、集电靴的设计与维修提供数据资料。     

船舶靠泊操纵评估模型

在船舶操纵模拟器培训和评估中,实现模拟操纵结果的自动评价并保证评价的公正、客观和准确已成为一个亟待解决的问题.通过对船舶靠泊操纵的深入研究,分析评估船舶靠泊操纵的指标,确定评估指标的隶属度值和权重,构建了船舶靠泊操纵评估模型.利用面向对象的Visual C#程序语言完成评估系统的开发和验证工作.     

拓扑优化技术在拱式纵梁码头结构中的应用

近年来,结构拓扑优化设计已成为结构优化研究领域的热点。针对新型的拱式纵梁码头结构,基于ANSYS有限元理论,采用拓扑优化方法对拱式纵梁的拱轴线线型进行选择,将得出的拱轴线应用于拱式纵梁码头结构中。通过实例证明了拓扑优化生成的拱轴线的合理性及其在工程应用中的可行性。