刚构体系独塔斜拉桥施工期抖振响应

为了更准确地计算桥梁抖振响应,以采用刚构体系的某带大挑臂钢箱结合梁独塔斜拉桥最大双悬臂施工阶段为研究对象,首先在有限元建模中重点讨论因塔梁固结处节点刚性区建模方法不同而导致的桥梁结构动力特性差异;随后运用二维不可压非定常雷诺平均URANS数值模拟方法,识别大挑臂钢箱主梁断面静力三分力系数和气动导纳;最后基于Davenp...     

港口通航环境对船舶航行安全的影响分析及评价

港口通航环境是发展航运所依托的重要资源之一。为了预防和减少海难事故的发生,降低港口船舶航行的危险程度,除了提高操船者的素质、船舶性能,还需要改善船舶通航环境。从水文气象因素、港口条件因素、航道条件因素、交通因素、水上水下施工作业5个方面对船舶通航安全的影响进行了分析,论述了港口通航环境安全评价的主要内容,提出了改善通航环境的治理对策。     

小门岛5万吨级煤码头工程潮流泥沙数模研究

使用TK-2D软件对小门岛5万吨级煤码头工程进行了研究,对港池开挖后的流速变化进行了分析,对泥沙回淤强度进行了预报。研究结果表明:(1)大、小门岛围垦工程及5万吨级煤码头港区开挖工程实施后,与现状情况相比,小门水道及开挖区涨、落潮流速普遍增加;(2)在大、小门岛围垦工程基础上5万吨级煤码头港区开挖后,与大、小门岛围垦工程情况相比,小门水道及开挖区涨、落潮流速减小;(3)港区开挖后,泥沙淤积不严重,开挖后水深能够维持住。     

物流基础设施投资机制研究

从我国物流基础设施投资机制的现状和存在的问题出发,借鉴国外发达国家物流投资模式,在综合分析的基础上提出了改善我国物流基础设施投资机制的相关对策和建议。     

基于轮速计算的乘用车小备胎识别策略开发及应用

汽车小备胎具备占用空间小,成本低廉的优势,在各类乘用车均得到较广泛的应用。但小备胎在滚动半径,轮辋偏置距等参数上与全尺寸备胎有一定差别,影响驾驶员在加速、制动及转向中的体验及行驶安全。通过对安装了小备胎的轮速进行计算,设置小备胎轮速识别门限,并建立小备胎识别状态机,整车搭载的控制单元如整车控制器,车身电子稳定控制系统等,可在车辆行驶一定时间后侦测到车辆是否安装小备胎。控制单元通过发送备胎识别总线报文,使整车关联节点接收到小备胎使用信息,针对小备胎的安装,提示驾驶员谨慎驾驶,调用动力控制单元驾驶模式,从而降低小备胎行驶中的安全风险,提升驾驶员驾驶体验。     

城市热环境规划调控研究—— 以郴州东部新城控规为例

城市夏季高温问题频发,城市气候环境急需缓解和优化.主要研究新城层面的热环境规划调控策略,采用基于CTTC模型的室外热环境分析工具DUTE(Design Urban Thermal Environment),以郴州市东部新城控制性详细规划为例,对新城范围内150个街区在控规指导下的室外热环境进行了微气候模拟和优化设计.使...     

实业家与慈善事业的结合——近代江苏实业家与晚清"义赈"的兴起

晚清时期的民间慈善事业在光绪初年时已发生一些新的变化,具体表现为江苏实业家成立新式慈善机构、改变传统赈灾观念、从事募捐善款、制定高效的放赈方式。实业家积极投身于大规模的民间赈灾活动,有力的促进了晚清时期“义赈”活动的兴起。     

沉思人与自然关系中的人类中心原则

现代高科技的迅猛发展,在给人类带来巨大利益的同时,也带来了许多令人难以预料的消极影响。其中,环境问题就是人类共同关注的现实问题,文章认为,坚持环境道德中的人类中心原则,才能维护人类与自然环境的关系,以达到人与自然的和谐发展。     

DIFFERENTIAL EXPRESSION OF GENES IN OMENTAL FAT OF NORMAL WEIGHT AND OBESE SUBJECTS AND OBESE DIABETIC PATIENTS USING cDNA MICROARRAY

Objective To identify genes differentially expressed in omental fat of normal weight subjects,obese subjects and obese diabetic patients. Methods Using a high-density cDNA microarray, gene expression profile of omental fat from normal weigh subjects, obese subjects and obese diabetic patients were compared.Results Totally, 119 and 257 genes were up-regulated in obese subjects and obese diabetic patients respectively,while 46 and 58 genes were down-regulated. A total of 77 genes, including PDK4, which switched from carbohydrate to fatty acids as the primary source of fuel, were up-regulated in both obese and obese diabetic patients, while 8 genes, including key enzymes in lipid synthesis, such as HMG-CoA synthase, fatty acid synthase and stearoyl-CoA desaturase, were down-regulated in both groups. Tyrosine-3-monooxygenase/tryptophan 5-monooxygenase activation protein θ ( YWHAZ) , a negative regulator for insulin signal transduction, was up-regulated only in obese diabetic patient, but not in normal-glycemic obese subjects. Conclusion The study demonstrated that decrease of lipogenesis along with increase of fatty acids oxidation of adipose tissue could be a common cause of insulin resistance in obesity and type 2 diabetes, while block of insulin signal transduction may trigger the transition from obesity to diabetes. Further exploration of these genes will be useful in the understanding of the pathogenesis of obesity and diabetes.     

SIMPLE METHOD OF PUNCHING AND RE-LOCATING TISSUES FOR MANUAL CONSTRUCTION OF TISSUE MICROARRAY

A series of human tissue samples and cultured cell lines were formalin-fixed and paraffin-embedded. Specimen cylinder ( 1.2 - 1.8mm) were punched by a modified bone marrow biopsy needle and arrayed on a recipient paraffin block. Microscopic analysis on the sections from this tissue microarray (TMA) block demonstrated that the spots of tissues and cells were well preserved, and the cultured cell samples were successfully embedded from 5 × 104 to 2 × 105 in number. These TMA sections were also suitable for immunohistochemistry and RNA in situ hybridization.