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Objective To study if using autologous lung as a substitute of oxygenator in cardiopulmonary bypass is better than the conventional cardiopulmonary bypass with artificial oxygenator in pulmonary preservation.Methods Twelve piglets were randomly divided into two groups ( n = 6). The isolated lung perfusion model was established. The experimental animals underwent continuous lung perfusion for about 120 min. While the control animals underwent 90 min lung ischemia followed by 30 min reperfusion. Another 12 piglets were randomly divided into two groups ( n =6). The experimental animals underwent bi-ventricular bypass with autologous lung perfusion.While control animals underwent conventional cardiopulmonary bypass with artificial oxygenator. The bypass time and aortic cross clamping time were 135 min and 60 min respectively for each animal. The lung static compliance ( Cstat), alveolus-artery oxygen difference ( PA-aO2 ), TNF-α, IL-6 and wet to dry lung weight ratio (W/D) were measured. Histological and ultra-structural changes of the lung were also observed after bypass. Results After either isolated lung perfusion or cardiopulmonary bypass, the Cstat decreased, the PA-aO2 increased and the content of TNF-α increased for both groups, but the changes of experimental group were much less than those of control group. The lower W/D ratio and mild pathological changes in experimental group than those in control group were also demonstrated. Conclusion Autologous lung is able to tolerate the nonpalsatile perfusion. It can be used as a substitute to artificial ogygenator in cardiopulmonary bypass to minimize the inflammatory pulmonary injury caused mainly by ischemic reperfusion and interaction of the blood to the non-physiological surface of artificial oxygenator. 相似文献
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Objective To investigate fingernail growth rate (FNGR) role in the physiological or pathological status of the fingernails in normal Chinese population. Methods The FNGR was measured with vernier caliper. The data of 1 595 fingernails from 208 normal Chinese subjects (including 96 men and 112 women; age ranging from 14 to 78 years) were analyzed. Results The average FNGR was (0.104±0.027) mm per day. Higher growth rates were observed in males than in females, in the young individuals than in the old individuals, in summer than in winter, and in the right hand than in the left hand, respectively. The FNGR differed among fingernails and decreased in order of precedence: middle fingernails, index fingernails or ring fingernails, thumb and little fingernails. Conclusion FNGR was significantly associated with age, gender and temperature. Different fingernail grew at an individual speed. 相似文献
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Growing numbers of users and many access control policies which involve many different resource attributes in service-oriented environments bring various problems in protecting resource.This paper analyzes the relationships of resource attributes to user attributes in all policies, and propose a general attribute and rule based role-based access control(GAR-RBAC) model to meet the security needs. The model can dynamically assign users to roles via rules to meet the need of growing numbers of users. These rules use different attribute expression and permission as a part of authorization constraints, and are defined by analyzing relations of resource attributes to user attributes in many access policies that are defined by the enterprise. The model is a general access control model, and can support many access control policies, and also can be used to wider application for service. The paper also describes how to use the GAR-RBAC model in Web service environments. 相似文献
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A kind of new design method for two-degree-of-freedom(2DOF)PID regulator was presented,in which,a new global search heuristic--improved generalized extremal optimization(GEO)algorithm is applied to the parameter optimization design of 2DOF PID regulator.The simulated results show that very good dynamic response performance of both command tracking and disturbance rejection characteristics can be achieved simultaneously.At the same time,the comparisons of simulation results with the improved GA,the basic GEO and the improved GEO were given.From the comparisons,it is shown that the improved GEO algorithm is competitive in performance with the GA and basic GEO and is an attractive tool to be used in the design of two-degree-of-freedom PID regulator. 相似文献
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Adaptive synchronization in NW small-world dynamical networks was studied.Firstly,an adaptive synchronization method is presented and explained.Then,it is applied to two different classes of dynamical networks,one is a class-B network,small-world connected R o¨ssler oscillators,the other is a class-A network,small-world connected Chua's circuits.The simulation verifies the validity of the presented method.It also shows that the adaptive synchronization method is robust to the variations of the node systems parameters.So the presented method can be used in networks whose node systems have unknown or time-varying parameters. 相似文献