废弃泥浆在盾构壁后注浆中的应用

在泥水盾构施工过程中不可避免地会产生大量的废弃泥浆,处理泥浆一是需要较高的资金投入,二是可能会对环境造成严重污染。利用废弃泥浆配制壁后注浆砂浆,利用盾构弃浆代替砂浆中的膨润土和水,研究弃浆对壁后注浆砂浆工程性能的影响。结果表明:1)相对体积质量为1.16、黏度为22 s的泥浆配制壁后注浆材料可得到较好的流动性和稠度,并且泌水率优于原配比;2)相对体积质量为1.27、黏度为24 s的泥浆会明显降低砂浆的流动度,对砂浆可泵送能力有一定的影响;3)适当调整水胶比和泥浆相对体积质量,配制壁后注浆材料各方面性能均能达到壁后注浆材料的要求;4)废弃泥浆配制砂浆是一种既经济又环保的弃浆处理回收再利用的工艺工法。     

基于灰色理论的雪山梁隧道施工过程渗漏水水源识别研究

为了解决黄龙景区雪山梁隧道开挖过程中的涌水水源识别问题,结合黄龙景区雪山梁隧道的相关施工资料,依据已有的地质资料和涌突水预测,通过水分析化学实验,采用灰色理论计算方法研究不同水系之间的关联度;而后针对单一水源和混合水源分别进行试验和分析,得出雪山梁隧道出口段内渗漏水来源最可能为大气降水,关联度较高的还有淘金沟上游水系和隧道出口处水系;最后进行比对,得出隧道渗漏水主要来源是大气降水和淘金沟上游水体的结论,并依据现场资料及实地踏勘,验证了灰色理论分析结果的可靠性。     

大型活动交通影响评价方法

大型活动吸引和产生的突增交通量会造成周边地区的交通拥挤。通过比较大型活动与大型商业建设项目的交通影响评价特点和分析大型活动交通管理的影响因素,分别针对“提供一次性服务的大型活动”和“提供长效服务的大型活动”,设计了交通需求的预测方法。以交叉口服务水平分析方法为基础,提出一种了大型活动的交通影响评价方法。以长春市南岭体育场举办的“中国足球甲A联赛”为对象,运用Vissim微观交通仿真软件对所提出的方法进行了初步验证。结果表明,在大型活动条件下,所提出的方法能够确定需要进行交通管制的空间范围。     

公路建设中的环境问题探讨

对公路建设环境保护作了比较深入地分析与探讨,总结归纳了公路施工环境保护工作的重点与措施。     

Effects of rosiglitazone on rabbit atherosclerosis

We sought to validate magnetic resonance imaging(MRI) for documenting the effects of rosiglitazone on rabbit atherosclerosis and the possible mechanism by treatment on the lesions.24 New Zealand white rabbits were randomly divided into normal group, control group and treatment group.After 4 weeks, all rabbits underwent MRI.After examination, the number of circulating endothelial progenitor cells(EPCs) and level of lipid, glucose, nitric oxide(NO) and superoxide anion(O-2·) were measured.MRI demonstrated the regression of atherosclerotic lesions by rosiglitazone which has good correlation with histopathology.Treatment not only increased the level of EPCs and NO, but also raised the ability of inhibition of O2-·.MRI is a promising noninvasive technology to detect the effects of therapeutic interventions.Rosiglitazone slows the progression of atherosclerosis that may in part attribute to its improvement of mobilization of EPCs and the reduced oxidative stress.     

A data model applied to the knowledge-based ICAS

Image-guided computer aided surgery system (ICAS) contributes to safeness and success of surgery operations by means of displaying anatomical structures and showing correlative information to surgeons in the process of operation. Based on analysis of requirements for ICAS, a new concept of clinical knowledge-based ICAS was proposed. Designing a reasonable data structure model is essential for realizing this new concept. The traditional data structure is limited in expressing and reusing the clinical knowledge such as locating an anatomical object, topological relations of anatomical objects and correlative clinical attributes. A data structure model called mixed adjacency lists by octree-path-chain (MALOC) was outlined, which can combine patient's images with clinical knowledge, as well as efficiently locate the instrument and search the objects' information. The efficiency of data structures was analyzed and experimental results were given in comparison to other traditional data structures. The result of the nasal surgery experiment proves that MALOC is a proper model for clinical knowledge-based ICAS that has advantages in not only locating the operative instrument precisely but also proving surgeons with real-time operation-correlative information. It is shown that the clinical knowledge-based ICAS with MALOC model has advantages in terms of safety and success of surgical operations, and help in accurately locating the operative instrument and providing operation-correlative knowledge and information to surgeons in the process of operations.     

铁路车辆编组连挂中车钩缓冲装置冲击特性分析

为了提高车辆编组连挂时的平稳性,保证所运货物的完整无损,通过对铁路车辆编组连挂时车钩缓冲装置的冲击特性进行分析,建立编组连挂时的缓冲装置的力学模型,对模型分析解微分方程得出位移时间曲线、加速度时间曲线以及加速度峰值,从而得出编组连挂的最大加速度与车钩系统的阻尼有关。     

TNFα、Leptin-Rb、NF-κB和PPAR-γ在酒精性肝病大鼠肝细胞中的表达

目的 探讨TNFα、NF-κB、Leptin-Rb和PPAR-γ等在大鼠酒精性肝病中与肝组织炎症、坏死和纤维化的关系.方法 胃造瘘法建立长期大鼠酒精性肝病模型,分别在第4、8、12、24和52周用免疫组化、原位杂交和RT-PCR技术检测不同阶段大鼠肝组织中TNFα、NF-κB、PPAR-γ和Leptin-Rb等的表达.结果 TNFα、NF-κB和Leptin-Rb水平在模型组大鼠肝细胞中,第8周表达逐渐增强,第24周起高水平表达一直持续至52周(P<0.01).PPAR-γ在对照组和第4、8周模型组肝细胞中表达最强,第12周表达开始减弱.TNFα和NF-κB在肝细胞中的表达呈明显正相关关系,与PPAR-γ则呈负相关关系(P<0.01).结论 TNFα和NF-κB与肝细胞病变程度有很好的一致性关系,Leptin-Rb在肝细胞的表达与肝纤维化发展相一致,PPAR-γ则刚好相反.     

快速老化小鼠的学习记忆缺陷及其生化机制

目的用快速老化小鼠(SAMP8)模拟老年痴呆,观察其学习记忆能力,并探讨其学习记忆能力下降的可能机制。方法采用10月龄SAMP8,并用同龄抗快速老化小鼠(SAMR1)作为正常对照。用水迷路检测近记忆以及空间学习记忆能力。用生物化学方法检测大脑皮层线粒体膜电位和ATP酶活力,观察线粒体功能;检测皮层和海马胆碱乙酰基转移酶(ChAT)和乙酰胆碱酯酶(AChE)的活力,观察中枢胆碱能神经功能;检测血清超氧化物歧化酶(SOD)活力和丙二醛(MDA)含量,观察其全身性氧化应激状况。结果与SAMR1相比,SAMP8出现明显的衰老体征,其近记忆和空间学习记忆能力明显减弱,具有衰老和痴呆特征;皮层线粒体膜电位和ATP酶活力显著降低,海马ChAT活力显著下降,AChE活力显著升高,血清SOD活力稍有增高。结论SAMP8可以很好地模拟老年痴呆,其机制包括大脑皮层线粒体功能降低、海马胆碱能神经功能下降以及氧化应激等。