Effect of ABCA1-V771M polymorphism on plasma lipid levels and its relationship with coronary atherosclerotic heart disease

Objective To explore the risk association of ABCA1-V771M polymorphism with coronary heart disease (CHD) in Hart nationality in Northwest of China. Methods With case-control study, ABCA1-V771M polymorphism was detected in 204 unrelated Hart nationality people in Northwest of China, and all the subjects by coronary angiography were grouped into 106 cases and 98 controls. The genotypes and alleles frequency distribution of ABCA1-V771M polymorphisms were analyzed by PCR-RFLP analysis, and the clinical statistics of serum lipids were compared and its effects of ABCA1-V771M polymorphism on the plasma lipid levels and coronary atherosclerotic heart disease were analyzed. Results The genotypic frequencies of ABCA1-V771M polymorphism matched well under Hardy-Weinberg equilibrium (P>0.05), V and M allelic frequencies were 33.3% and 66.7%. In comparison with VV VM genotype carriers, MM genotypes carriers had much lower plasma levels of HDL-C (P<0. 001) and much higher plasma levels of TG (P<0. 05). M allelic frequency in CHD group was significantly higher than V allelic frequency (P<0. 05). M allele was related with more severity of atherosclerosis in the coronary artery than V allele (P<0.05). However, there was no obvious difference in the incidence of AMI among carriers with three genotypes of ABCA1-V771M polymorphism (P>0.05). Conclusion ABCA1-V771M polymorphism was not only associated with the plasma levels of HDL-C and TG, but also related to the susceptibility and severity of coronary atheroselerotic heart disease. Moreover, M771 allele appeared to be atherogenie among Han population in Northwest of China.     

低阻通风船体的远程控制测试平台开发（英文）

This paper addresses the development and testing of a remotely controlled boat platform with an innovative air-ventilated hull. The application of air cavities on the underside of ship hulls is a promising means for reducing hydrodynamic drag and pollutant emissions and increasing marine transportation efficiency. Despite this concept’s potential, design optimization and high-performance operation of novel air-cavity ships remain a challenging problem. Hull construction and sensor instrumentation of the model-scale air-cavity boat is described in the paper. The modular structure of the hull allows for easy modifications, and an electric propulsion unit enables self-propelled operation. The boat is controlled remotely via a radio transmission system. Results of initial tests are reported, including thrust, speed, and airflow rate in several loading conditions. The constructed platform can be used for optimizing air-cavity systems and testing other innovative hull designs. This system can be also developed into a high-performance unmanned boat.     

A havelock source panel method for near-surface submarines

A panel method is described for calculating potential flow around near-surface submarines. The method uses Havelock sources which automatically satisfy the linearized free-surface boundary condition. Outputs from the method include pressure field, pressure drag, wave resistance, vertical force, trim moment and wave pattern. Comparisons are made with model tests for wave resistance of Series 58 and DARPA SUBOFF hulls, as well as with wave resistance, lift force and trim moment of three length-to-diameter variants of the DSTO Joubert submarine hull. It is found that the Havelock source panel method is capable of determining with reasonable accuracy wave resistance, vertical force and trim moment for submarine hulls. Further experimental data are required in order to assess the accuracy of the method for pressure field and wave pattern prediction. The method is implemented in the computer code “HullWave” and offers potential advantages over RANS-CFD codes in terms of speed, simplicity and robustness.     

A non-geometrically similar model for predicting the wake field of full-scale ships

The scale effect leads to large discrepancies between the wake fields of model-scale and actual ships, and causes differences in cavitation performance and exciting forces tests in predicting the performance of actual ships. Therefore, when test data from ship models are directly applied to predict the performance of actual ships, test results must be subjected to empirical corrections. This study proposes a method for the reverse design of the hull model. Compared to a geometrically similar hull model, the wake field generated by the modified model is closer to that of an actual ship. A non- geometrically similar model of a Korean Research Institute of Ship and Ocean Engineering (KRISO)’s container ship (KCS) was designed. Numerical simulations were performed using this model, and its results were compared with full-scale calculation results. The deformation method of getting the wake field of full-scale ships by the non-geometrically similar model is applied to the KCS successfully.     

Experimental and numerical investigations on vibration characteristics of a loaded ship model

In this paper, vibration characteristics of the structure in the finite fluid domain are analyzed using a coupled finite element method. The added mass matrix is calculated with finite element method (FEM) by 8-node acoustic fluid elements. Vibration characteristics of the structure in finite fluid domain are calculated combining structure FEM mass matrix. By writing the relevant programs, numerical analysis on vibration characteristics of a submerged cantilever rectangular plate in finite fluid domain and loaded ship model is performed. A modal identification experiment for the loaded ship model in air and in water is conducted and the experiment results verify the reliability of the numerical analysis. The numerical method can be used for further research on vibration characteristics and acoustic radiation problems of the structure in the finite fluid domain.     

Numerical calculation of supercavitating flows over the disk cavitator of a subsonic underwater projectile

To deal with the effect of compressible fluids on the supercavitating flow over the subsonic disk cavitator of a projectile, a finite volume method is formulated based on the ideal compressible potential theory. By using the continuity equation and Tait state equation as well as Riabouchinsky closure model, an “inverse problem” solution is presented for the supercavitating flow. According to the impenetrable condition on the surface of supercavity, a new iterative method for the supercavity shape is designed to deal with the effect of compressibility on the supercavity shape, pressure drag coefficient and density field. By this method, the very low cavitation number can be computed. The calculated results agree well with the experimental data and empirical formula. At the subsonic condition, the fluid compressibility will make supercavity length and radius increase. The supercavity expands, but remains spheroid. The effect on the first 1/3 part of supercavity is not obvious. The drag coefficient of projectile increases as the cavitation number or Mach number increases. With Mach number increasing, the compressibility is more and more significant. The compressibility must be considered as far as the accurate calculation of supercavitating flow is concerned.     

天津海河综合开发工程桥梁建设梗概

主要介绍了天津市海河综合开发工程中的桥梁建设情况。按照总体规划要求,从满足功能、景观、区域历史文化需要,以崭新的设计理念进行桥梁设计,营造出现代化的城市氛围,弘扬海河文化,使海河成为独具特色的世界名河。     

开目CAPP在武船机制的应用

武昌造船厂机械制造分厂(简称武船机制)是武昌造船厂的下属核心企业,主要进行武船配套零部件的工艺设计与制造。在推进信息化建设过程中,采用了开目CAPP解决方案,取得了较好的效果。武船机制工艺信息化系统需求分析1.产品和工艺特点分析(1)产品的质量要求高,工期要求严格,对工艺设计质量和效率有很高的要求。(2)采用按订单生产的方式,进行独立的成本核算和控制。(3)需从总厂ERP系统中提取工程任务树,建立工艺设计与制造任务。设计完成的工艺数据也需按照ERP系统要求的格式进行统计并向ERP系统进行传递。(4)不同订单中的工艺专业种类繁…     

地面注汽管线表面散热损失影响因素分析

文中采用Fluent模拟与理论计算结合比较的方法,研究了不同因素对蒸汽管道散热损失的影响规律,并分析了理论计算模型的相对误差.发现增加注汽管线距地面高度,对其散热损失影响较弱;空气温度升高,注汽管道表面散热损失降低;风速和表面发射率对注汽管线表面热损失影响较大;数值模拟结果与理论计算数据相对误差较大.