Effect of ABCA1-V771M polymorphism on plasma lipid levels and its relationship with coronary atherosclerotic heart disease

Objective To explore the risk association of ABCA1-V771M polymorphism with coronary heart disease (CHD) in Hart nationality in Northwest of China. Methods With case-control study, ABCA1-V771M polymorphism was detected in 204 unrelated Hart nationality people in Northwest of China, and all the subjects by coronary angiography were grouped into 106 cases and 98 controls. The genotypes and alleles frequency distribution of ABCA1-V771M polymorphisms were analyzed by PCR-RFLP analysis, and the clinical statistics of serum lipids were compared and its effects of ABCA1-V771M polymorphism on the plasma lipid levels and coronary atherosclerotic heart disease were analyzed. Results The genotypic frequencies of ABCA1-V771M polymorphism matched well under Hardy-Weinberg equilibrium (P>0.05), V and M allelic frequencies were 33.3% and 66.7%. In comparison with VV VM genotype carriers, MM genotypes carriers had much lower plasma levels of HDL-C (P<0. 001) and much higher plasma levels of TG (P<0. 05). M allelic frequency in CHD group was significantly higher than V allelic frequency (P<0. 05). M allele was related with more severity of atherosclerosis in the coronary artery than V allele (P<0.05). However, there was no obvious difference in the incidence of AMI among carriers with three genotypes of ABCA1-V771M polymorphism (P>0.05). Conclusion ABCA1-V771M polymorphism was not only associated with the plasma levels of HDL-C and TG, but also related to the susceptibility and severity of coronary atheroselerotic heart disease. Moreover, M771 allele appeared to be atherogenie among Han population in Northwest of China.     

地震作用下框架-复合墙结构弹塑性内力计算

框架-复合墙结构是以框架和密肋复合剪力墙共同承担水平地震作用的新型组合式双重抗侧力体系,合理计算弹塑性阶段框架与复合墙的内力是决定大震下结构体系安全性能的关键问题之一.根据6榀典型密肋复合墙试验数据,建立了复合墙体指数式刚度退化模型,量化了墙体在各变形阶段的刚度退化系数.在对比复合墙与框架、混凝土墙、砌体墙刚度退化规律的基础上,分析了复合墙刚度退化对结构受力性能的影响,提出了弹塑性阶段框架-复合墙结构地震内力的实用计算方法,并通过具体算例讨论了结构内力的变化情况.研究结果表明：弹塑性阶段,框架与密肋复合墙刚度退化速度比值呈非线性关系,框架分担总地震剪力的比例增加,但其绝对剪力值增加幅度并不明显;考虑弹塑性阶段复合墙的刚度退化,更好地符合了地震下框架-复合墙结构的实际受力情况.     

Biologically induced modification of seawater viscosity in the Eastern English Channel during a Phaeocystis globosa spring bloom

To identify the potential relationship between Pheaocystis globosa bloom conditions and seawater properties, a hydrobiological survey was performed in the inshore waters of the Eastern English Channel over the course of the phytoplankton spring bloom. Chlorophyll concentration, auto- and hetero/mixotrophic composition of protists and standing stock, and seawater viscosity were measured weekly from March to June 2004. The decline of the bloom is characterized by a massive foam formation in the turbulent surf zone. Before foam formation, seawater viscosity significantly increased, showing a significant positive correlation with chlorophyll concentration. In contrast, after foam formation this correlation was negative, seawater viscosity kept increasing despite a sharp decrease in chlorophyll concentrations. No significant correlation has been found between seawater viscosity and the composition of the phytoplankton assemblages observed during the survey. However, significant positive correlations have been found between seawater viscosity and both the size and the abundance of P. globosa colonies. From the correlation patterns observed between chlorophyll concentration and seawater viscosity, we suggest that the rheological properties of seawater are mainly driven by extracellular materials associated with colony formation and maintenance rather than by cell composition and standing stock.     

On the observability of the fortnightly cycle of the Tagus estuary turbid plume using MODIS ocean colour images

Using three years (2003 to 2005) of MODIS-Aqua normalized water-leaving radiance at 551 nm this paper shows a fortnightly cycle in the Tagus estuary turbid plume. The Tagus estuary is one of the largest estuaries of the west coast of Europe and is located in the most populated area of Portugal, including the capital Lisbon. The turbid plume has been detected by the backscattering characteristics of the surface waters in the vicinity of the estuary mouth. In fortnightly scales, the turbid plume has smaller dimensions during and after neap tides and higher dimensions during and after spring tides. This is most probably associated with the fortnightly spring–neap tidal cycle and the consequent increase in turbidity inside the estuary during spring tides. During the summer weak spring tides (tidal amplitude approximately 2.5 m) no turbid plume is observed for an entire fortnightly cycle. Outside the summer months, precipitation, river discharge and winds, were found to increase the turbid area, but the fortnightly cycle appears to be superimposed on the large time-scale variability, and present throughout the year.     

Quasi-two-dimensional flow on the polar β-plane: Laboratory experiments

Geophysical turbulence is strongly affected by the variation of the Coriolis parameter with latitude. This variation results in the so-called β-effect, which forces energy from small-scales to be transferred preferentially into zonal motions. This effect results in the formation of narrow jet-like zonal flows that dominate the dynamics and act as transport barriers. Here, laboratory experiments are used to reproduce this effect in decaying turbulent flows. An electromagnetic cell is used to generate an initial field of vorticity in a rotating tank. Under conditions of quasi-geostrophic flow, the β-effect is produced by depth variation of the flow instead of variation of the Coriolis parameter. The effects of changing the container geometry and the overall fluid depth on the production of jets are investigated. The results suggest that this laboratory configuration can be used to model jet formation in the oceans and that increasing fluid depth is a practical way to decrease viscous effects.     

Characteristic flow patterns generated by macrozoobenthic structures

A laboratory flume channel, equipped with an acoustic Doppler flow sensor and a bottom scanning laser, was used for detailed, non-intrusive flow measurements (at 2 cm s^− 1 and 10 cm s^− 1) around solitary biogenic structures, combined with high-resolution mapping of the structure shape and position. The structures were replicates of typical macrozoobenthic species commonly found in the Mecklenburg Bight and with a presumed influence on both, the near-bed current regime and sediment transport dynamics: a worm tube, a snail shell, a mussel, a sand mound, a pit, and a cross-stream track furrow. The flow was considerably altered locally by the different protruding structures (worm tube, snail, mussel and mound). They reduced the horizontal approach velocity by 72% to 79% in the wake zone at about 1–2 cm height, and the flow was deflected around the structures with vertical and lateral velocities of up to 10% and 20% of the free-stream velocity respectively in a region adjacent to the structures. The resulting flow separation (at flow Reynolds number of about 4000 and 20,000 respectively) divided an outer deflection region from an inner region with characteristic vortices and the wake region. All protruding structures showed this general pattern, but also produced individual characteristics. Conversely, the depressions (track and pit) only had a weak influence on the local boundary layer flow, combined with a considerable flow reduction within their cavities (between 29% and 53% of the free-stream velocity). A longitudinal vortex formed, below which a stagnant space was found. The average height affected by the structure-related mass flow rate deficit for the two velocities was 1.6 cm and 1.3 cm respectively (80% of height and 64%) for the protruding structures and 0.6 cm and 0.9 cm (90% and 127% of depth) for the depressions. Marine benthic soft-bottom macrozoobenthos species are expected to benefit from the flow modifications they induce, particularly in terms of food particle capture due to altered particle pathways and residence times, but also for the exchange of gases, solutes and spawn. The present results confirm previous studies on flow interaction effects of various biogenic structures, and they add a deeper level of detail for a better understanding of the fine-scale effects.     

Further study on the ultimate strength analysis of spherical pressure hulls

From a comparative study it is concluded that current design rules for the spherical pressure hull of manned submersible need to be updated and unified. In this paper, a series of spherical pressure hulls are calculated by nonlinear FEM. Based on these numerical results, the influence of critical arch length and the relationship of ultimate strength with t/R and structural imperfection are studied. Finally, empirical formulae for the ultimate strength of the titanium alloy spherical pressure hull of deep manned submersible based on numerical computations are given. The formulae can be used as the core equations to update current design rules.     

Altimeter assimilation in the OCCAM global model: Part I: A twin experiment

An altimeter data assimilation scheme has been tested in the OCCAM (Ocean Circulation and Climate Advanced Modelling) global 1/4°, 36-level model using a twin experiment format. The Cooper and Haines displacement scheme is used. The method works well in most regions and depths. Currents and densities in the top 1000 m generally improve by over 50–70% after 5 months of sea level assimilation every 15 days. Below 1000 m, an error reduction of up to 50% is achieved. The errors remain low during a further 60-day run without assimilation. Diagnostics for the North Atlantic, the Tropical Pacific and the Antarctic Circumpolar Current are shown alongside the global averages.The main problems encountered were in weakly stratified regions of the Antarctic and Arctic seas. A scale selective filter is developed to avoid assimilating scales much larger than the local deformation radius, and this avoids the adverse assimilation effects in the southern oceans. A companion paper uses this scheme to assimilate TOPEX and ERS-1 altimeter maps.     

Impact of phytoplankton community size on a linked global ocean optical and ecosystem model

We isolated the effect phytoplankton cell size has on varying remote sensing reflectance spectra (R_rs(λ)) in the presence of optically active constituents by using optical and radiative transfer models linked in an offline diagnostic calculation to a global biogeochemical/ecosystem/circulation model with explicit phytoplankton size classes. Two case studies were carried out, each with several scenarios to isolate the effects of chlorophyll concentration, phytoplankton cell size, and size-varying phytoplankton absorption on R_rs(λ). The goal of the study was to determine the relative contribution of phytoplankton cell size and chlorophyll to overall R_rs(λ) and to understand where a standard band ratio algorithm (OC4) may under/overestimate chlorophyll due to R_rs(λ) being significantly affected by phytoplankton size. Phytoplankton cell size was found to contribute secondarily to R_rs(λ) variability and to amplify or dampen the seasonal cycle in R_rs(λ), driven by chlorophyll. Size and chlorophyll were found to change in phase at low to mid-latitudes, but were anti-correlated or poorly correlated at high latitudes. Phytoplankton size effects increased model calculated R_rs(443) in the subtropical ocean during local spring through early fall months in both hemispheres and decreased R_rs(443) in the Northern Hemisphere high latitude regions during local summer to fall months. This study attempts to tease apart when/where variability about the OC4 relationship may be associated with cell size variability. The OC4 algorithm may underestimate [Chl] when the fraction of microplankton is elevated, which occurs in the model simulations during local spring/summer months at high latitudes in both hemispheres.     

热带海洋大气中的3004铝和∝铜的原电池反应(英文)

The galvanic corrosion behaviour of aluminium 3004-∝brass with different area ratios was studied in the tropical marine atmosphere at Tuticorin harbour over a period of 426 days. The area ratios, viz. A Aluminium:A∝ brass, studied were 0.125, 0.25, 0.5, 1, 2, 4 and 8. The galvanic corrosion behaviour of the metals was studied in terms of the relative increase in the corrosion rate of aluminium due to galvanic coupling with ∝ brass, the relative decrease in the corrosion rate of ∝ brass due to galvanic coupling with aluminium, and the susceptibility of aluminium to pitting owing to galvanic coupling with ∝ brass. The galvanic potential and galvanic current of the system were monitored. Pits of different dimensions ranging from mild etchings to perforations were experienced on the borders and the surfaces of the interface of aluminium in contact with ∝ brass. The corrosion products resulting from galvanic corrosion were analysed using XRD and the pitting on aluminium as a result of galvanic corrosion was highlighted in terms of pit depth, size and density of pit, using a high resolution microscope. The most favourable area ratio of aluminium-∝ brass in marine atmosphere in terms of gravimetric corrosion rate is 8:1 and the most unfavourable area ratio of aluminium-∝ brass is 1:4.