Effect of ABCA1-V771M polymorphism on plasma lipid levels and its relationship with coronary atherosclerotic heart disease

Objective To explore the risk association of ABCA1-V771M polymorphism with coronary heart disease (CHD) in Hart nationality in Northwest of China. Methods With case-control study, ABCA1-V771M polymorphism was detected in 204 unrelated Hart nationality people in Northwest of China, and all the subjects by coronary angiography were grouped into 106 cases and 98 controls. The genotypes and alleles frequency distribution of ABCA1-V771M polymorphisms were analyzed by PCR-RFLP analysis, and the clinical statistics of serum lipids were compared and its effects of ABCA1-V771M polymorphism on the plasma lipid levels and coronary atherosclerotic heart disease were analyzed. Results The genotypic frequencies of ABCA1-V771M polymorphism matched well under Hardy-Weinberg equilibrium (P>0.05), V and M allelic frequencies were 33.3% and 66.7%. In comparison with VV VM genotype carriers, MM genotypes carriers had much lower plasma levels of HDL-C (P<0. 001) and much higher plasma levels of TG (P<0. 05). M allelic frequency in CHD group was significantly higher than V allelic frequency (P<0. 05). M allele was related with more severity of atherosclerosis in the coronary artery than V allele (P<0.05). However, there was no obvious difference in the incidence of AMI among carriers with three genotypes of ABCA1-V771M polymorphism (P>0.05). Conclusion ABCA1-V771M polymorphism was not only associated with the plasma levels of HDL-C and TG, but also related to the susceptibility and severity of coronary atheroselerotic heart disease. Moreover, M771 allele appeared to be atherogenie among Han population in Northwest of China.     

低阻通风船体的远程控制测试平台开发（英文）

This paper addresses the development and testing of a remotely controlled boat platform with an innovative air-ventilated hull. The application of air cavities on the underside of ship hulls is a promising means for reducing hydrodynamic drag and pollutant emissions and increasing marine transportation efficiency. Despite this concept’s potential, design optimization and high-performance operation of novel air-cavity ships remain a challenging problem. Hull construction and sensor instrumentation of the model-scale air-cavity boat is described in the paper. The modular structure of the hull allows for easy modifications, and an electric propulsion unit enables self-propelled operation. The boat is controlled remotely via a radio transmission system. Results of initial tests are reported, including thrust, speed, and airflow rate in several loading conditions. The constructed platform can be used for optimizing air-cavity systems and testing other innovative hull designs. This system can be also developed into a high-performance unmanned boat.     

调车内燃机车用TK18B-57型涡轮增压器

介绍了TK18B-57型涡轮增压器的技术特点;得出了装用该型增压器的8ДМ-21/21型柴油机的试验结果;给出了柴油机流体特性及在所有工况下的参数变化图表.     

高速列车新型制动系统

从最初在原苏联到后来在俄罗斯,高速列车制动系统的研制工作已历经40余年。在此期间开发、研制并通过试验的列车有:РТ2000型、ЭР200型、Сокол型、涅夫斯基高速列车、反向牵引机车。所列这些机车车辆均具有保证安全运行所必需的设备:统一型“牵引—制动”控制器、快速作用式电空制动机、再生电阻制动机、磁轨和盘形制动机、防滑行装置、空气弹簧等。Сокол型高速列车的电空制动系统已通过了250km/h速度的试验。制动机微机控制和仪器工况诊断系统已在地铁列车和РА1型内燃动车上应用了10多年。本文介绍了由制动设备设计院为速度达300km/h、节数较少的高速列车和地铁列车开发的新型制动系统的结构、功能及主要技术参数。     

140 km/h大吨位集装箱平车的制动系统

介绍了最高运行速度可达140 km/h的"快速"大吨位集装箱平车制动试验的过程和结果,提出了改进这种远景平车制动系统的建议.     

使用有限元分析以改善重载运输车轴

分析了北美铁路货运发生的车轴故障,介绍了使用有限元对F级和K级车轴进行应力分析计算,研究车轴尺寸变化对应力的影响,并提出了改善重载车轴设计的建议.     

CA-3型自动车钩装置钩尾销的疲劳寿命

介绍了俄罗斯4家工厂生产的CA-3型自动车钩钩尾销的试验台试验结果,并指出为提高运行安全性,有必要采用钩尾销疲劳特性的规范要求.     

机车轴承部件车载诊断系统

文内介绍了以АРП-11型轴承寿命分析仪为基础的机车轴承部件车载诊断系统的作用、结构和使用结果。     

ISS-based robust adaptive fuzzy algorithm for maintaining a ship's track

This paper focuses on the problem of linear track keeping for marine surface vessels. The influence exerted by sea currents on the kinematic equation of ships is considered first. The input-to-state stability(ISS) theory used to verify the system is input-to-state stable. Combining the Nussbaum gain with backstepping techniques,a robust adaptive fuzzy algorithm is presented by employing fuzzy systems as an approximator for unknown nonlinearities in the system. It is proved that the proposed algorithm that guarantees all signals in the closed-loop system are ultimately bounded. Consequently,a ship's linear track-keeping control can be implemented. Simulation results using Dalian Maritime University's ocean-going training ship 'YULONG' are presented to validate the effectiveness of the proposed algorithm.     

完整街道的完整性评估

衡量完整街道完整性的工具可以被用于制定政策、决定基础设施投资优先考虑的区域以及如何分配单个街道的路权。回顾了评估完整街道设计最前沿的研究文献。评估完整街道必须先建立基于现实情况的完整性评定标准,而此标准需通过建立街道分类体系将不同类型街道优先体现的功能和预期目标相结合。标准指标体系应体现街道的完整程度,包括交通、环境及场所等要素,同时也应足够灵活,从而能够阐述实现这些功能的各种方法。除极个别外,文献回顾的大多数指标体系都不适合用来评估完整街道,因为这些评估体系大多仅衡量街道是否具备特定的设计要素。另外,一条街道的完整性还可以依据其交通运行、环境和场所方面的标准来评估,也可以与所属街道分类制定的预期目标进行比较。因此,考量一条街道涉及很多因素,如何界定完整街道的优劣及评价指标仍然有许多工作要做。