真空降水联合低能量强夯加固吹填土路基

结合上海某临港新城大面积吹填土地基处理工程,试验研究了真空降水联合低能量强夯加固大面积吹填土路基问题,对加固过程中及加固后的地下水位变化、超静孔压变化、工艺参数、以及加固机理进行了分析和讨论。在此基础上确定了大面积施工的参数和工艺。真空降水联合低能量强夯的技术进一步拓宽了井点降水和强夯法的适用范围,为我国沿海地区工程建设中遇到的大面积吹填土加固问题提供了新的途径。     

独墩单铰支座曲线梁桥通病分析及治理

针对目前独墩单铰支座曲线梁桥出现的通病 ,就温度对其梁体的变位影响以及预应力等因素对其支座支反力的作用进行了实例剖析。在此基础上探讨此类桥梁的支承体系的病害整治对策 ,并通过加固实例的监测结果予以验证     

Effect of ABCA1-V771M polymorphism on plasma lipid levels and its relationship with coronary atherosclerotic heart disease

Objective To explore the risk association of ABCA1-V771M polymorphism with coronary heart disease (CHD) in Hart nationality in Northwest of China. Methods With case-control study, ABCA1-V771M polymorphism was detected in 204 unrelated Hart nationality people in Northwest of China, and all the subjects by coronary angiography were grouped into 106 cases and 98 controls. The genotypes and alleles frequency distribution of ABCA1-V771M polymorphisms were analyzed by PCR-RFLP analysis, and the clinical statistics of serum lipids were compared and its effects of ABCA1-V771M polymorphism on the plasma lipid levels and coronary atherosclerotic heart disease were analyzed. Results The genotypic frequencies of ABCA1-V771M polymorphism matched well under Hardy-Weinberg equilibrium (P>0.05), V and M allelic frequencies were 33.3% and 66.7%. In comparison with VV VM genotype carriers, MM genotypes carriers had much lower plasma levels of HDL-C (P<0. 001) and much higher plasma levels of TG (P<0. 05). M allelic frequency in CHD group was significantly higher than V allelic frequency (P<0. 05). M allele was related with more severity of atherosclerosis in the coronary artery than V allele (P<0.05). However, there was no obvious difference in the incidence of AMI among carriers with three genotypes of ABCA1-V771M polymorphism (P>0.05). Conclusion ABCA1-V771M polymorphism was not only associated with the plasma levels of HDL-C and TG, but also related to the susceptibility and severity of coronary atheroselerotic heart disease. Moreover, M771 allele appeared to be atherogenie among Han population in Northwest of China.     

The role of interleukin-8 produced by tumor induced fibroblasts in the development of cutaneous melanoma

Objective To determine the role of interleukin-8 (IL-8) produced by tumor induced fibroblasts in the development of cutaneous melanoma. Methods B16 melanoma cells induced L929 fibroblasts phenotype was transdifferentiated to myofibroblasts (MF) by co-culture in vitro. MF was monitored by morphology and immunophenotype for a-SMA. The level of IL-8 was detected by ELISA. The effect on B16 cell proliferation rate was estimated using MIT method in vitro. Melanoma implanting model was constructed in C57 mice. Results L929 MF phenotype could be modulated by B16 melanoma cells-derived transforming growth factor-β1 (TGF-β1) and elevated the levels of IL-8. L929 MF did not influence the B16 melanoma cells viability in vitro, but shortened the time of tumor formation and increased the incidence rates of tumors in C57 implanting model mice. Conclusion Fibroblasts can be activated by tumor cells and produce IL-8, which acts as an inflammatory cytokine promoting the development of cutaneous melanoma.     

复杂水文地质环境条件下等级公路的灾害防治研究

为了有效预防、治理各类复杂特殊岩土体公路自然灾害和人类活动、区域地质构造环境极端变化诱发的公路灾害,文章在分析公路灾害孕育、诱发、发生、发展过程中地下水补、径、排等关键水文地质致灾条件和灾害类型的基础上,详细研究了公路灾害的成灾机理特征,诱发、影响因素及防治措施。提出了对公路建设全过程的公路灾害安全评价和以勘探、预防预报、治理地表水、地下水运动变化等水文地质条件关键点为核心的公路灾害治理与防治技术措施。     

沙棘果油及沙棘籽油对大鼠放射性皮肤损伤的影响

目的观察沙棘果油及沙棘籽油对大鼠放射性皮肤损伤的影响。方法实验用深部X线治疗机,每次以3000 cGy的剂量,照射两次,造成大白鼠臀部放射性皮肤损伤。待动物症状明显后,将Ⅱ度皮肤损伤的动物随机分为6组,即阴性对照组、沙棘果油高剂量组、沙棘果油低剂量组、沙棘籽油高剂量组、沙棘籽油低剂量组以及阳性对照组。沙棘果油及籽油高剂量组,每天在损伤部位涂药两次,而其低剂量组每天涂药一次,阴性对照组每天涂灭菌的注射用水一次,阳性对照组每天涂Solcoseryl-Jelly软膏一次。结果肉眼观察结果显示,连续用药10d后,沙棘果油、籽油及Sol-coseryl-Jelly组动物的局部红斑、水肿明显减轻,创面分泌物明显减少,用药2周后,上述症状明显消退,与阴性对照组比较,明显好转;另外,沙棘果油、籽油及Solcoseryl-Jelly组的创面愈合时间明显缩短。光学显微镜观察结果显示,沙棘果油、籽油及Solcoseryl-Jelly组的皮肤损伤明显减轻,炎症反应亦明显减轻,创面修复明显。电子显微镜观察结果显示,阴性对照组的超微结构明显受损,而沙棘果油、籽油及Solcoseryl-Jelly组的损伤明显减轻。结论沙棘果油及沙棘籽油对大鼠放射性皮肤损伤有明显的治疗作用。     

人工关节磨损测量方法综述

人工关节的磨损问题是制约我国人工关节矫形术全面开展的重要因素之一,而磨损的检测和分析技术是评价磨损的手段。随着新技术、新材料等的发展,对人工关节磨损的检测提出新的要求,其中越来越迫切需要精确实现人工关节微量磨损的数字化检测、分析和表征。文章论述了目前国内外主要测量方法,分析了各自的特点和优点,这对于人工关节磨损的测量及其研究具有参考价值。     

复合主拱圈加固双跨空腹式石拱桥应用与研究

结合贵州省兴义市楼下长征桥（双跨空腹式石拱桥）加固项目,采用＂钢筋混凝土复合主拱圈＂加固技术提高旧桥承载能力。综合运用＂极限状态法＂和＂容许应力法＂评价加固后桥梁承载能力,从而对加固修复中、小跨径旧石拱桥,延长桥梁使用寿命,具有重要的现实指导意义。     

夹心钢板系统加固正交异性钢桥面板的性能分析

正交异性钢桥面板广泛应用在现代钢桥中,但在车辆荷载作用下,由于较高的应力集中易引起关键焊接部位的疲劳裂纹,采用夹心钢板系统（SPS）对正交异性钢桥面板进行加固。通过ANSYS软件建立了正交异性钢桥面板及其SPS加固层的三维有限元模型,在不同的荷载工况下,分析了按我国现行规范规定的车辆荷载的两个后轴共同作用下桥面板的应力分布特征,并与加固前的应力状态进行了对比。结果表明：骑U肋加载在桥面板时U肋焊接处产生的横桥向应力最大;采用SPS对正交异性钢桥面板进行加固的效果良好,与加固前相比,可较大幅度地降低钢桥面板的应力,更有助于抵抗钢桥面板疲劳裂纹的产生。