大跨度中承式钢管系杆混凝土拱桥设计和体会

介绍了一座较大跨度的中承式钢管系杆混凝土拱桥—朝阳东大桥的设计思路和工程主要技术特点,并就设计过程当中的一些体会,对钢管混凝土拱桥的应用提出了一些看法,可以给业内同行提供参考,对今后大跨拱桥设计提供借鉴。     

对铁岭市银州路和广裕街交叉口改建工程的评价

重点从平面交叉口工程设计、交通安全设施、壮观和谐等三个方面对铁岭市银州路和广裕街平面交叉口工程进行评价。     

盐通高铁与宁启铁路交叉并线区段GSM-R方案研究

盐通高铁与宁启铁路在海安、如皋地区存在多处交叉并线,交叉并线区段GSM-R覆盖方案已成为铁路通信系统的设计重点和难点.对盐通高铁与宁启铁路交叉并线区段的GSM-R覆盖方案进行研究,并从建设投资、运营维护、网络优化、频率规划等方面分析各个方案的优缺点,最终提出工程实施方案,为今后类似工程提供了工程案例.     

基于Faster R-CNN与形态法的路面病害识别

为提高基于图像处理的路面表观病害检测识别效率及精度,引入目标检测中的快速区域卷积神经网络(Faster Region Convolutional Neural Network,Faster R-CNN)算法以快速识别病害种类、位置与面积;针对已提取的带边框裂缝病害区域,采用基于VGG16迁移学习与模型微调的CNN与50...     

新型光纤光栅测量法在系杆拱桥索力监测中的应用

为保证系杆拱桥的安全和正常工作,必须加强桥梁索力监测.由于光纤光栅的优越性,现已成为工程健康监测领域的研究热点,但现有方法尚未成熟,因此研究一种新型光纤光栅索力监测技术,即光纤光栅基座夹具测量法,并将此方法应用在新建的龙苴大桥索力实时监测中.监测结果表明:光纤光栅基座夹具测量法及实施方案的可行性和准确性,检测数据可靠.此方法既可监测实际张拉过程中索力,也可在张拉结束后进行索力持续监测,为系杆拱桥的安全监测起到重要的补充及改进作用.     

Techno-economic study of LNG diesel power (dual fuel) ship

This article mainly proposed three technically effective alternatives to comply with the emission control regulations and laws in shipping. Liquefied natural gas (LNG)-diesel dual fuel power technology was introduced through feasibility study on several aspects including research development, retrofitting methods, vessel type, safety issues, and other technical characteristics. Based on sample ship and route, economic evaluation was conducted on these three alternatives. Cost-effectiveness of each project was detailed in the calculation of net present value (NPV) and payback time via discount cash flow method. The findings show that LNG-diesel dual fuel power technology performs best among three alternatives. Due to the impact of fuel price, two scenarios were carried out in sensitivity analysis which witnessed a variation of NPV with the fluctuation of fuel price. Further study shows the turning point between project (i) and project (iii) with different discount rate and the interaction between discount rate and fuel price, left project (ii) the least cost-effective solution in three alternatives.     

TNFα、Leptin-Rb、NF-κB和PPAR-γ在酒精性肝病大鼠肝细胞中的表达

目的 探讨TNFα、NF-κB、Leptin-Rb和PPAR-γ等在大鼠酒精性肝病中与肝组织炎症、坏死和纤维化的关系.方法 胃造瘘法建立长期大鼠酒精性肝病模型,分别在第4、8、12、24和52周用免疫组化、原位杂交和RT-PCR技术检测不同阶段大鼠肝组织中TNFα、NF-κB、PPAR-γ和Leptin-Rb等的表达.结果 TNFα、NF-κB和Leptin-Rb水平在模型组大鼠肝细胞中,第8周表达逐渐增强,第24周起高水平表达一直持续至52周(P<0.01).PPAR-γ在对照组和第4、8周模型组肝细胞中表达最强,第12周表达开始减弱.TNFα和NF-κB在肝细胞中的表达呈明显正相关关系,与PPAR-γ则呈负相关关系(P<0.01).结论 TNFα和NF-κB与肝细胞病变程度有很好的一致性关系,Leptin-Rb在肝细胞的表达与肝纤维化发展相一致,PPAR-γ则刚好相反.     

Study on T lymphocyte subsets and NK cells in patients with Graves＇ disease combined with type 2 diabetes

Objective To investigate changes in T lymphocyte subsets and NK cells in patients with simple Graves' disease (GD)and Graves' disease combined with type 2 diabetes mellitus (GD/T2DM). Methods Fifteen cases of GD/ T2DM were selected from our hospital from November 2001 to November 2004. Before and after therapy thyroid function, thyroglobulin antibody (TGA), thyroid microsomal antibody (TMA) and blood glucose level were measured, and T lymphocyte subsets (CD3, CD4, CD8, CD4/CD8) and NK cells (CD56) were measured by immunofluorescence double labeling monoclonal antibody and flow cytometry, respectively. At the same time, comparison was made with simple GD (15 cases), T2DM (15 cases) and healthy control (20 cases). Results Before therapy, CD4/CD8, CD4 and NK cells in GD/T2DM were less than normal, and there was no significant difference in comparison with simple GD (P<0.05). In T2DM group, only CD4/CD8 and CD4 were less than those of healthy controls (P<0.05). When thyroid function recovered after 1 to 3 months of methimazole treatment in both GD/T2DM and simple GD groups, various indexes recovered, which were more obvious in simple GD. Conclusion Immune hypofunction of GD may be the key to the immune abnormality of GD/T2DM, which is more significant than that of simple GD or T2DM. The recovery of thyroid function and immune abnormality is not consistent, and the recovery of GD is more significant than that of GD/T2DM.     

饲料加硼对摄入过量氟的实验大鼠骨损伤的预防作用

目的探讨饲料加硼对过量氟摄入的大鼠骨损伤的预防作用。方法24只4-5周龄Sprague-Dawley(SD)大鼠分为:对照组(喂饲基础饲料,饮蒸馏水)、过量氟组[喂饲基础饲料,饮含100mg/LF-(氟化钠221mg/L的蒸馏水)]、硼预防组(喂饲加硼饲料,饮含100mg/LF-的蒸馏水)。实验3月后测量大鼠血清氟、硼含量及血清碱性磷酸酶(alkaline phosphatase,AKP)活性、骨氟和骨总RNA含量、胫骨纵径横径和干重及骨密度(bone mineral density,BMD),并检测大鼠股骨生物力学特性。结果和对照组比较,过量氟组大鼠血清氟、骨氟含量和血清AKP活性显著增高;骨总RNA含量、全身骨骼平均BMD和胫骨BMD降低;胫骨纵径、横径和干重减小;股骨最大负荷减低,最大形变增加。相比过量氟组,硼预防组大鼠血清氟和骨氟含量及AKP活性明显下降;骨总RNA含量、全身骨骼平均BMD、腰椎和胫骨BMD显著增高;胫骨纵径、横径和干重,股骨最大负荷明显增加。3组大鼠血清硼含量无显著性差异。结论大鼠摄入过量氟可出现明显的骨损伤,饲料加硼对此有一定的预防作用。     

海底埋设管线平管起吊运动分析

基于有限元软件OrcaFlex,充分考虑不规则波浪、海流、管土相互作用以及船舶管线耦合运动,建立海底埋设管线平管起吊模型。参考DNV-RP-F110计算埋深管道受到的土壤阻力,依据DNV-RP-C205确定相关水动力系数。通过数值模拟研究分析管线在平管起吊过程中管道的运动响应以及吊绳张力的时间历程变化,为实际海底管线平管起吊提供一定理论参考。