Effect of ABCA1-V771M polymorphism on plasma lipid levels and its relationship with coronary atherosclerotic heart disease

Objective To explore the risk association of ABCA1-V771M polymorphism with coronary heart disease (CHD) in Hart nationality in Northwest of China. Methods With case-control study, ABCA1-V771M polymorphism was detected in 204 unrelated Hart nationality people in Northwest of China, and all the subjects by coronary angiography were grouped into 106 cases and 98 controls. The genotypes and alleles frequency distribution of ABCA1-V771M polymorphisms were analyzed by PCR-RFLP analysis, and the clinical statistics of serum lipids were compared and its effects of ABCA1-V771M polymorphism on the plasma lipid levels and coronary atherosclerotic heart disease were analyzed. Results The genotypic frequencies of ABCA1-V771M polymorphism matched well under Hardy-Weinberg equilibrium (P>0.05), V and M allelic frequencies were 33.3% and 66.7%. In comparison with VV VM genotype carriers, MM genotypes carriers had much lower plasma levels of HDL-C (P<0. 001) and much higher plasma levels of TG (P<0. 05). M allelic frequency in CHD group was significantly higher than V allelic frequency (P<0. 05). M allele was related with more severity of atherosclerosis in the coronary artery than V allele (P<0.05). However, there was no obvious difference in the incidence of AMI among carriers with three genotypes of ABCA1-V771M polymorphism (P>0.05). Conclusion ABCA1-V771M polymorphism was not only associated with the plasma levels of HDL-C and TG, but also related to the susceptibility and severity of coronary atheroselerotic heart disease. Moreover, M771 allele appeared to be atherogenie among Han population in Northwest of China.     

低阻通风船体的远程控制测试平台开发（英文）

This paper addresses the development and testing of a remotely controlled boat platform with an innovative air-ventilated hull. The application of air cavities on the underside of ship hulls is a promising means for reducing hydrodynamic drag and pollutant emissions and increasing marine transportation efficiency. Despite this concept’s potential, design optimization and high-performance operation of novel air-cavity ships remain a challenging problem. Hull construction and sensor instrumentation of the model-scale air-cavity boat is described in the paper. The modular structure of the hull allows for easy modifications, and an electric propulsion unit enables self-propelled operation. The boat is controlled remotely via a radio transmission system. Results of initial tests are reported, including thrust, speed, and airflow rate in several loading conditions. The constructed platform can be used for optimizing air-cavity systems and testing other innovative hull designs. This system can be also developed into a high-performance unmanned boat.     

A havelock source panel method for near-surface submarines

A panel method is described for calculating potential flow around near-surface submarines. The method uses Havelock sources which automatically satisfy the linearized free-surface boundary condition. Outputs from the method include pressure field, pressure drag, wave resistance, vertical force, trim moment and wave pattern. Comparisons are made with model tests for wave resistance of Series 58 and DARPA SUBOFF hulls, as well as with wave resistance, lift force and trim moment of three length-to-diameter variants of the DSTO Joubert submarine hull. It is found that the Havelock source panel method is capable of determining with reasonable accuracy wave resistance, vertical force and trim moment for submarine hulls. Further experimental data are required in order to assess the accuracy of the method for pressure field and wave pattern prediction. The method is implemented in the computer code “HullWave” and offers potential advantages over RANS-CFD codes in terms of speed, simplicity and robustness.     

A non-geometrically similar model for predicting the wake field of full-scale ships

The scale effect leads to large discrepancies between the wake fields of model-scale and actual ships, and causes differences in cavitation performance and exciting forces tests in predicting the performance of actual ships. Therefore, when test data from ship models are directly applied to predict the performance of actual ships, test results must be subjected to empirical corrections. This study proposes a method for the reverse design of the hull model. Compared to a geometrically similar hull model, the wake field generated by the modified model is closer to that of an actual ship. A non- geometrically similar model of a Korean Research Institute of Ship and Ocean Engineering (KRISO)’s container ship (KCS) was designed. Numerical simulations were performed using this model, and its results were compared with full-scale calculation results. The deformation method of getting the wake field of full-scale ships by the non-geometrically similar model is applied to the KCS successfully.     

Experimental and numerical investigations on vibration characteristics of a loaded ship model

In this paper, vibration characteristics of the structure in the finite fluid domain are analyzed using a coupled finite element method. The added mass matrix is calculated with finite element method (FEM) by 8-node acoustic fluid elements. Vibration characteristics of the structure in finite fluid domain are calculated combining structure FEM mass matrix. By writing the relevant programs, numerical analysis on vibration characteristics of a submerged cantilever rectangular plate in finite fluid domain and loaded ship model is performed. A modal identification experiment for the loaded ship model in air and in water is conducted and the experiment results verify the reliability of the numerical analysis. The numerical method can be used for further research on vibration characteristics and acoustic radiation problems of the structure in the finite fluid domain.     

Numerical calculation of supercavitating flows over the disk cavitator of a subsonic underwater projectile

To deal with the effect of compressible fluids on the supercavitating flow over the subsonic disk cavitator of a projectile, a finite volume method is formulated based on the ideal compressible potential theory. By using the continuity equation and Tait state equation as well as Riabouchinsky closure model, an “inverse problem” solution is presented for the supercavitating flow. According to the impenetrable condition on the surface of supercavity, a new iterative method for the supercavity shape is designed to deal with the effect of compressibility on the supercavity shape, pressure drag coefficient and density field. By this method, the very low cavitation number can be computed. The calculated results agree well with the experimental data and empirical formula. At the subsonic condition, the fluid compressibility will make supercavity length and radius increase. The supercavity expands, but remains spheroid. The effect on the first 1/3 part of supercavity is not obvious. The drag coefficient of projectile increases as the cavitation number or Mach number increases. With Mach number increasing, the compressibility is more and more significant. The compressibility must be considered as far as the accurate calculation of supercavitating flow is concerned.     

Home-to-work commuting,urban form and potential energy savings: A local scale approach to regional statistics

The link between transport energy consumption and land use patterns has been the focus of a considerable amount of academic works over the past decades. While many empirical researches are backed up with solid statistical techniques, most of them do not fully consider the influence of scale underlying empirical quantitative investigations. Using fine-scale home-to-work commuting data for Wallonia (Belgium), this paper re-evaluates Breheny’s (1995) assertion that urban structure should hold the characteristics of major cities if substantial energy savings are to be achieved. A local scale approach highlights efficient settlements in terms of transport energy consumption not only within major towns, but also within remote rural areas. Furthermore, results suggest that influencing the urban form following local energy efficient examples rather than regional ones could also yield significant gains, without an extreme policy stance of re-urbanisation in major cities.     

An analysis of destination choice for opaque airline products using multidimensional binary logit models

We investigate how customers respond to an opaque airline product offered by a European carrier. In this opaque product design, customers are randomly assigned to travel to one of approximately ten destinations; however, for a fee they may exclude one or more destinations from the choice set (or a particular package design) prior to learning which destination they will travel to. We use a multidimensional binary logit model to predict the probability that one or more alternatives will be chosen by a customer. Results show that customers are more likely to pay to exclude destinations located close to the origin airport and destinations that speak the same language as the origin airport. Length of stay, cost of living at the destination, and measures of destination attractiveness are also found to be significant predictors for some package designs. Based on these findings, we offer general recommendations for how to design opaque packages for airline customers.     

A Sociological Approach to Maritime Studies: A Statement and Example

This paper is an attempt to illustrate the stance of the Soviet Union in the law of the sea debate in the light of Soviet ocean activities. The paper has two sections. First, it examines the range of Soviet ocean activities. The considerable extent of Soviet ocean use underscores the importance which the Soviet Union places on the law of the sea debate and its consequent active participation in the process of international negotiation. Second, the paper considers the published record of the Soviet Union in the United Nations seabed debate. In seven years of debate the United Nations General Assembly and the Ad Hoc and permanent Seabed Commities and sub-Commities have generated a considerable body of documantation reflecting the public policy of over one hundred States concerning the law of the sea. Soviet expressions of opinion alone cover more than five hundred pages of documentation. Specific Soviet positions can be considered within two ganeral preferences: the protection of traditional freedoms of the high seas and opposition to ocean control by either coastal States or by an independent international ocean authority. The paper shows how these preferences and the specific Soviet negotiating positions defend and promote the maritime interests of the Soviet Union.