一种基于卫星导航的列车初始定位方法研究

在西北环境恶劣地区,线路区间往往较少设置实体应答器,列车在区间重启时需要长距离低速运行.经过实体应答器后才能确定列车位置。针对该问题.本文提出一种基于卫星导航系统和车载电子地图的列车初始定位方法。该方法利用轨道约束算法和概率学方法,设计满足铁路安全标准要求的列车初始定位方法。     

某大型公务船的振动性能评估

采用有限元法评估了某大型公务船的振动性能,包括主机激励和螺旋桨激励下的全船总振动响应,以及上层建筑、后桅和雷达桅的局部振动响应。计算结果表明全船总振动性能良好,但后桅和雷达桅部分结构振动较为剧烈。通过改进设计,最终使全船振动性能满足ISO 6954(1984)的振动标准。     

铁路预应力路堤加固技术数值研究

研究目的:铁路预应力路堤在国内外尚属一种新型路基加固法,其受力变形特性暂未得到系统化研究,相关加固设计理论仍处于探索性阶段。因此,有必要通过数值手段了解预应力路堤的工作状态,以掌握其加固性能。鉴于此,借助ABAQUS软件平台构建预应力路堤仿真系统,分析差异化预应力加固参数对路堤变形和承载能力的影响以及预应力加固构件的受力特征。研究结论:(1)路堤本体段坡面较优加固位置为距本体顶面以下0.3倍本体高度处;(2)坡率1∶1的预应力路堤在第1、2排侧压板分别施加50 k Pa、100 k Pa预压荷载时,其变形与承载力均可达传统路堤(坡率1∶1.5)水平,并可通过提升加固标准进一步强化路堤承载性能;(3)当对第1、2、3排侧压板分别施加50 k Pa、100 k Pa、100 k Pa预压荷载时,路堤内部附加围压S11>13.5 k Pa区域大致呈"x"形分布并形成横贯路堤的"预压加固区";(4)侧压板锚固区受力集中且复杂,应注意保障锚固区板体强度;(5)力筋在路堤加载前后的应力变化量与坡面侧向变形特征相关;(6)本研究成果可为铁路预应力路堤的加固设计提供技术指导。     

北京市公共交通票制票价改革的交通影响评估

通过采集北京市公共交通客运量、客流压力、乘客乘车距离、票价水平等方面的数据,并借助乘客出行意愿调查,分析了公共交通票制票价改革对城市交通特别是公共交通运行的影响。     

Estimation of delay variability at signalized intersections for urban arterial performance evaluation

Urban arterial performance evaluation has been broadly studied, with the major focus on average travel time estimation. However, in view of the stochastic nature of interrupted flow, the ability to capture the characteristics of travel time variability has become a critical step in determining arterial level of service (LOS). This article first presents a stochastic approach that integrates classic cumulative curves and probability theories in order to investigate delay variability at signalized intersections, as a dominant part of the link travel time variability. This serves as a basis for arterial travel time estimation, which can be obtained through a convolution of individual link travel time distributions. The proposed approach is then applied in the estimation of travel time along one arterial in Shanghai, China, with abundant automatic vehicle identification (AVI) data sources. The travel time variability is evaluated thoroughly at 30-min intervals, with promising results achieved in comparison to the field measurements. In addition, the estimated travel time distributions are utilized to illustrate the probability of multiple LOS ranges, namely, reliability LOS. The results provide insights into how we might achieve a more reliable and informative understanding of arterial performance.     

柴油机活塞销孔型线对比分析研究

针对某柴油机活塞销孔的磨损问题,分别借助有限元方法和EHD仿真方法研究了不同销座结构匹配多种销孔型线对接触应力的影响,及不同活塞销孔型线对润滑特征评价参数的影响。综合研究表明,活塞销孔型线与热变形匹配不合理所引起的润滑状态恶化是导致活塞销孔磨损的直接原因,因此通过合理调整销孔型线可使接触应力均匀,润滑状态良好,并有效降低活塞销座磨损风险。     

无坎宽顶堰流量系数的计算及讨论

通过采用二元非线性回归分析方法对多个数学模型进行分析,结合实测资料,得到了水利工程中无坎宽顶堰流量系数的经验公式,克服了查表法中需要通过多步直线内插带来的不便,更适合在水力计算中应用。     

高等级公路沥青路面平整度的控制

结合几年来的公路施工经验,根据影响路面平整度主要因素,分析设备及施工工艺方面应注意的主要事项,以提高高速公路路面的平整度.     

降钙素基因相关肽与内皮素受体A在兔实验性蛛网膜下腔出血后基底动脉的表达

目的探讨蛛网膜下腔出血(SAH)后脑血管内皮细胞降钙素基因相关肽(CGRP)及内皮素受体A(ETRA)的表达与迟发性脑血管痉挛(DCVS)之间的关系。方法日本大耳白家兔60只,随机分为SAH模型组25只,盐水组25只,穿刺组5只,正常组5只。采用枕大池二次注血法制作SAH模型,灌注处死后取基底动脉制成切片。进行CGRP及ETRA的免疫组化和HE染色,观察CGRP与ETRA的免疫表达和病理结构变化,并用图像分析方法测量血管周长,使用方差分析进行统计学检验。结果基底动脉周长在SAH后均发生明显缩窄,其中在5d时缩小最强烈。CGRP与ETRA免疫阳性标记颗粒在SAH组的基底动脉组织中均有表达,其动态变化规律为CGRP的表达在1h时最明显,在3、5d依次表达减少,5d达到最低点,7d后开始逐渐升高,10d时表达相对比较明显,但未能达到正常水平,CGRP在穿刺组、正常对照组和盐水组也有散在不规则表达。在正常组、穿刺组和盐水组的基底动脉内ETRA有表达;SAH组基底动脉内ETRA在3d组和5d组表现为高表达,以3d组为强,而其中血管内皮细胞表达最强烈,平滑肌也有表达,10d组的表达仍然较强。结论在SAH后脑血管内皮细胞CGRP和ETRA的表达呈现明显的动态改变,但二者的变化趋势并不同步;CGRP和ETRA在DCVS的发生发展中起重要的作用。     

The role of interleukin-8 produced by tumor induced fibroblasts in the development of cutaneous melanoma

Objective To determine the role of interleukin-8 (IL-8) produced by tumor induced fibroblasts in the development of cutaneous melanoma. Methods B16 melanoma cells induced L929 fibroblasts phenotype was transdifferentiated to myofibroblasts (MF) by co-culture in vitro. MF was monitored by morphology and immunophenotype for a-SMA. The level of IL-8 was detected by ELISA. The effect on B16 cell proliferation rate was estimated using MIT method in vitro. Melanoma implanting model was constructed in C57 mice. Results L929 MF phenotype could be modulated by B16 melanoma cells-derived transforming growth factor-β1 (TGF-β1) and elevated the levels of IL-8. L929 MF did not influence the B16 melanoma cells viability in vitro, but shortened the time of tumor formation and increased the incidence rates of tumors in C57 implanting model mice. Conclusion Fibroblasts can be activated by tumor cells and produce IL-8, which acts as an inflammatory cytokine promoting the development of cutaneous melanoma.