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Objective To investigate changes in T lymphocyte subsets and NK cells in patients with simple Graves' disease (GD)and Graves' disease combined with type 2 diabetes mellitus (GD/T2DM). Methods Fifteen cases of GD/ T2DM were selected from our hospital from November 2001 to November 2004. Before and after therapy thyroid function, thyroglobulin antibody (TGA), thyroid microsomal antibody (TMA) and blood glucose level were measured, and T lymphocyte subsets (CD3, CD4, CD8, CD4/CD8) and NK cells (CD56) were measured by immunofluorescence double labeling monoclonal antibody and flow cytometry, respectively. At the same time, comparison was made with simple GD (15 cases), T2DM (15 cases) and healthy control (20 cases). Results Before therapy, CD4/CD8, CD4 and NK cells in GD/T2DM were less than normal, and there was no significant difference in comparison with simple GD (P<0.05). In T2DM group, only CD4/CD8 and CD4 were less than those of healthy controls (P<0.05). When thyroid function recovered after 1 to 3 months of methimazole treatment in both GD/T2DM and simple GD groups, various indexes recovered, which were more obvious in simple GD. Conclusion Immune hypofunction of GD may be the key to the immune abnormality of GD/T2DM, which is more significant than that of simple GD or T2DM. The recovery of thyroid function and immune abnormality is not consistent, and the recovery of GD is more significant than that of GD/T2DM. 相似文献
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A new hierarchical approach called bintree energy segmentation was presented for color image segmentation. The image features are extracted by adaptive clustering on multi-channel data at each level and used as the criteria to dynamically select the best chromatic channel, where the segmentation is carried out. In this approach, an extended direct energy computation method based on the Chan-Vese model was proposed to segment the selected channel, and the segmentation outputs are then fused with other channels into new images, from which a new channel with better features is selected for the second round segmentation. This procedure is repeated until the preset condition is met. Finally, a binary segmentation tree is formed, in which each leaf represents a class of objects with a distinctive color. To facilitate the data organization, image background is employed in segmentation and channels fusion. The bintree energy segmentation exploits color information involved in all channels data and tries to optimize the global segmentation result by choosing the "best" channel for segmentation at each level. The experiments show that the method is effective in speed, accuracy and flexibility. 相似文献
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对我国北方地区最大的公路病害——道路冻胀翻浆的成因、危害程度均作了详细的论述。并从理论上和设计、施工方面提出了切实可行的防治措施,对公路工程的设计、施工具有广泛的指导意义和实用性。 相似文献
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简述了主动磁轴承的工作原理及数学模型,在传统系统辨识的基础上提出了基于BP神经网络的非线性辨识方案.通过闭环控制使转子稳定悬浮,并在控制器的输出信号中加入随机噪声,以使系统被充分激励.按照10 kHz的采样频率对磁轴承的I/O数据进行采样,以用于磁轴承特性的辨识.对某单自由度磁轴承的仿真表明,神经网络模型能够以很高的精度逼近磁轴承的输入输出数据,且对不同的输入信号有较好的泛化能力,验证了所提方案的有效性. 相似文献
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从理论上对钢板梁桥横向加固效果进行了定性分析,并应用大型有限元分析软件AN-SYS建立了加固前后桥梁结构的三维空间有限元模型。通过模态分析获得了加固前后结构前10阶自振频率和振型,并对几种方案的加固效果进行了定量分析,得出有意义的结论。 相似文献