P物质和表皮生长因子受体在早期银屑病发病中的作用

目的　探讨P物质 (substanceP ,SP)和表皮生长因子受体 (epidermalgrowthfactorreceptor ,EGFR)在银屑病发病早期的作用机制。方法　用放射免疫法检测正常组织和各期银屑病皮损处SP和EGFR的表达状况。结果　进行期银屑病患者和静止期银屑病患者皮损处SP明显高于恢复期患者和正常人 (P <0 .0 5 )。进行期和静止期银屑病患者皮损表皮中EGFR阳性表达明显高于正常皮肤 (P <0 .0 5 ) ;恢复期皮损的阳性表达与正常组织无显著差异性 (P >0 .0 5 )。结论　SP和EGFR可能在银屑病发病的早期阶段相互协同而起关键作用     

新月拱桥结构静动力特性分析

以某城市景观桥梁——新月拱桥为工程背景,运用Midas Civil建立全桥空间杆系有限元模型,对其施工全过程的静态受力、动力特性及稳定性进行分析。研究结果表明:空间桥跨结构受力合理,具有良好的刚度与强度;结构振动基频为0.93 Hz,为横向1阶;各主要施工阶段的稳定安全系数均大于4.0,具有良好的稳定性。     

车用催化器载体蜂窝孔内气流分析

本文利用流动数值计算（CFD）的方法研究催化转化器载体蜂窝孔内的气流分布，通过研究发现在空速很低时在扩张段就出现气流分离现象，而在载体人口端流速分布则比较均匀；在载体蜂窝内随着空速的增加气流状态由层流向紊流转变，因此不能简单地将其气流简化为不可压层流。     

Study on T lymphocyte subsets and NK cells in patients with Graves＇ disease combined with type 2 diabetes

Objective To investigate changes in T lymphocyte subsets and NK cells in patients with simple Graves' disease (GD)and Graves' disease combined with type 2 diabetes mellitus (GD/T2DM). Methods Fifteen cases of GD/ T2DM were selected from our hospital from November 2001 to November 2004. Before and after therapy thyroid function, thyroglobulin antibody (TGA), thyroid microsomal antibody (TMA) and blood glucose level were measured, and T lymphocyte subsets (CD3, CD4, CD8, CD4/CD8) and NK cells (CD56) were measured by immunofluorescence double labeling monoclonal antibody and flow cytometry, respectively. At the same time, comparison was made with simple GD (15 cases), T2DM (15 cases) and healthy control (20 cases). Results Before therapy, CD4/CD8, CD4 and NK cells in GD/T2DM were less than normal, and there was no significant difference in comparison with simple GD (P<0.05). In T2DM group, only CD4/CD8 and CD4 were less than those of healthy controls (P<0.05). When thyroid function recovered after 1 to 3 months of methimazole treatment in both GD/T2DM and simple GD groups, various indexes recovered, which were more obvious in simple GD. Conclusion Immune hypofunction of GD may be the key to the immune abnormality of GD/T2DM, which is more significant than that of simple GD or T2DM. The recovery of thyroid function and immune abnormality is not consistent, and the recovery of GD is more significant than that of GD/T2DM.     

采用预防性养护改进路面管理系统

着眼于如何采用预防性养护改进路面管理系统,使路面管理系统支持预防性养护计划的制定;提出整合的方法,分析每一种方法的优缺点,讨论整合的必要性以及在整合过程中可能遇到的问题,最后为如何有效的把预防性养护整合到路面管理系统中提供了一些技术措施。     

基于CFD的空气滤清器入口结构改进设计

采用基于时均Navier-Stokes方程和高雷诺数k-ε紊流模型,对某一型号空气滤清器入口部分进行了流动计算,并根据计算结果对压力、速度特性进行了分析,提出了改进模型。通过对改进后模型的计算,可以看出内部流场和流速的分布都得到了改善,证明改进后的结构更符合气体流动特性。     

生物接触氧化法处理洗浴废水的填料选择研究

生物接触氧化法处理洗浴废水的填料选择研究以软性纤维和软性泡沫作为备选填料,采用活性污泥挂膜法,浅析了膜培养过程中的影响因素.最后通过最佳水力停留时间这一废水处理指标对备选填料进行比较,最终选择软性泡沫作为动态实验填料.     

口语训练对增强学生参与课堂积极性的作用探讨

提高大学生外语运用的综合能力是外语教学的重点也是难点,本文通过分析影响大学生课堂积极性的以部分因素,结合新的考评方式试图探索出一套既能提高学生课堂积极性又能灵活评估的英语口语教学思路与模式。     

PTEN和PCNA在子宫内膜癌组织中的表达

目的探讨抑癌基因PTEN及增殖细胞核抗原(PCNA)在子宫内膜癌中的表达及临床意义。方法应用免疫组化SP法检测PTEN和PCNA在18例正常增生期子宫内膜(正常组)、21例子宫内膜不典型增生(癌前病变组)和22例子宫内膜腺癌(内膜癌组)中的表达。结果正常组、癌前病变组及内膜癌组PCNA表达分别为61.1%(11/18)、71.4%(15/21)和95.5%(21/22),3组间比较,差异有统计学意义(P<0.05);各组子宫内膜组织中PTEN表达分别为:正常组88.9%(16/18)、癌前病变组71.4%(15/21)、内膜癌组27.3%(6/22),3组间比较,差异有统计学意义(P<0.05)。结论PCNA表达增强可能是子宫内膜癌在分子水平上的早期变化,PTEN表达减弱可能与子宫内膜腺癌的发生、发展密切相关,二者对早期诊断子宫内膜癌有一定意义。     

INVESTIGATION ON THE DYNAMIC RESPONSE PERFORMANCE OF A NOVEL THREE-WAY SOLENOID VALVE

In order to meet the increasinglystrict emissionstandards andi mprove the perfor mance of diesel en-gines,using electronic control systemin diesel en-gines becomes more and more popular.In the com-mon-rail injection system of diesel engines,injec-tion ti ming and injection duration are controlled bythe solenoid valve.The perfor mance of common-rail injection systemis directly deter mined by thesolenoid valve[1-2].A novel high-speed three-waysolenoid valve used in the common-rail injectionsyste…