拱架式预切槽施工机械在黄土隧道施工中的应用

隧道预切槽施工技术在国外应用比较广泛,但在我国应用还较少。针对黄土地质专项研制了国内首台拱架式预切槽机,并在黄土隧道进行了施工试验。通过施工试验,掌握设备定位、分区切灌、设备行走、施工作业组织等关键技术,并提出应用改进及优化措施。试验结果表明切槽系统工作状态和设备切削、喷灌功能满足设计及施工试验要求,为预切槽同步切削喷灌一体化研究提供了数据支撑和研究方向。     

基于系统优化平衡模型的P&R分配技术研究

为探索如何有效合理地选择停车换乘设施,提出了一种服务于停车换乘者停车行为的系统优化平衡模型.本文选取停车场的可用性为影响出行者选择的主要因素,以总停车阻抗最小为目标建立了系统优化平衡模型,通过具体实例分析,证明该模型较为简捷.     

Flow Stress Model of Stainless Steel OCr13Ni5Mo at Elevated Temperature

For a more accurate forming calculation and numerical simulation of hydraulic turbine blade,experimental studies on the flow stress of stainless steel OCr13Ni5Mo were carried out upon Gleeble-1500 thermal simulator under different deformation conditions.The results then were analyzed and the effects of all influencing factors were summarized consequently.New mathematic models were conceived.Utilizing the software Matlab,regression coefficients were calculated by the least square method.The model has an eminent capability of curve-fitting performance with impact structure whose correlation coefficient is up to 0.908 0 and the cosine coefficient is 0.995 8.All mathematic models and process parameters can be used in engineering calculations or computer simulations.     

A data model applied to the knowledge-based ICAS

Image-guided computer aided surgery system (ICAS) contributes to safeness and success of surgery operations by means of displaying anatomical structures and showing correlative information to surgeons in the process of operation. Based on analysis of requirements for ICAS, a new concept of clinical knowledge-based ICAS was proposed. Designing a reasonable data structure model is essential for realizing this new concept. The traditional data structure is limited in expressing and reusing the clinical knowledge such as locating an anatomical object, topological relations of anatomical objects and correlative clinical attributes. A data structure model called mixed adjacency lists by octree-path-chain (MALOC) was outlined, which can combine patient's images with clinical knowledge, as well as efficiently locate the instrument and search the objects' information. The efficiency of data structures was analyzed and experimental results were given in comparison to other traditional data structures. The result of the nasal surgery experiment proves that MALOC is a proper model for clinical knowledge-based ICAS that has advantages in not only locating the operative instrument precisely but also proving surgeons with real-time operation-correlative information. It is shown that the clinical knowledge-based ICAS with MALOC model has advantages in terms of safety and success of surgical operations, and help in accurately locating the operative instrument and providing operation-correlative knowledge and information to surgeons in the process of operations.     

英国职业教育特色与启示

文章介绍了中英职业教育合作项目的背景与进展,研究了英国当前的职业教育状况,分析了先进的教育经验．并对合作项目下的汽修课程体系改革作出了规划。     

羟基喜树碱对人胆管癌QBC939裸鼠移植瘤PS2、COX-2的影响

目的探讨羟基喜树碱对人胆管癌QBC939裸鼠移植瘤的乳癌相关肽(PS2)、环氧合酶-2(COX-2)的影响,分析PS2、COX-2与肿瘤发生、发展的关系。方法建立人胆管癌QBC939细胞株裸鼠皮下移植瘤模型,将30只裸鼠随机分成对照组、羟基喜树碱低剂量组和羟基喜树碱高剂量组,观察移植瘤体生长情况,RT-PCR法检测瘤体内PS2、COX-2 mRNA表达。结果与对照组比,羟基喜树碱低、高剂量组都可使移植瘤体的PS2 mRNA表达增高;COX-2 mRNA表达降低,且瘤体生长减慢,与对照组比较差异有统计学意义(P<0.01)。结论羟基喜树碱可降低移植瘤COX-2 mRNA表达,增高移植瘤体的PS2 mRNA表达,并使人胆管癌裸鼠移植瘤生长减慢。     

NT4-Ant-Shepherdin[79-87]融合基因重组载体的构建

目的设计构建携带NT4-Ant-Shepherdin[79-87]的cDNA融合基因的重组载体,为针对Survivin的靶向治疗奠定基础。方法应用非对称引物/模板法、PCR技术制备NT4-Ant-Shepherdin[79-87]cDNA片断,连接于pGEM-T-Easy载体,经克隆测序、酶切后与PBV220/NT4质粒连接;转化感受态细胞E.coliDH5α,亚克隆获得NT4-Ant-Shepherdin[79-87]融合基因。结果克隆出Ant-Shepherdin[79-87]基因,经酶切及测序证实结果正确;连接PBV220/NT4,经克隆、酶切,琼脂糖凝胶电泳证实获得321bp的NT4-Ant-Shepherdin[79-87]目的基因片断。结论通过分子生物学技术成功构建了携带NT4-Ant-Shepherdin[79-87]融合基因的重组载体,为进一步研究针对Survivin的靶向抗肿瘤作用奠定了基础。     

健胃愈疡颗粒对慢性胃炎伴幽门螺杆菌感染胃黏膜PAF、PS2的表达及对上皮细胞凋亡的影响

目的观察健胃愈疡颗粒(JWYY)对幽门螺杆菌相关性胃炎胃黏膜乳癌相关肽(PS2)和血小板活化因子(plate-let activating factor,PAF)表达的变化,并分析其可能的作用机制。方法80例幽门螺杆菌感染慢性胃炎患者随机分为2组,治疗组42例给予健胃愈疡颗粒治疗,对照组38例给予西药三联药物治疗。应用胃镜下活检胃黏膜组织快速尿素酶和Warthin-Starry染色法检测幽门螺杆菌,应用Western blot检测PS2、PAF表达变化。应用末端转移酶介导的dUTP切口末段标记法(TUNEL)检测细胞凋亡。第4周复查胃镜。结果治疗组凋亡指数明显比对照组减少(P<0.05),治疗组总有效率高于对照组(P<0.05)。Western blot检测显示:JWYY颗粒可上调PS2并下调PAF的表达,而对照组对胃黏膜PS2和PAF的表达影响不大。结论健胃愈疡颗粒治疗幽门螺杆菌(Hp)相关性胃炎可能与杀灭Hp、上调PS2和下调PAF的表达来抑制细胞凋亡有关。     

潮流电站载体结构强度直接计算

潮流发电是一种新型的潮汐能利用技术,具有广阔的发展前景。潮流电站载体结构的设计好坏直接关系到潮流电站的安全性和可靠性。针对某潮流电站,建立载体结构有限元模型,参照相关规范要求,对其强度进行计算分析。计算结果表明:各个分析工况下的屈服和屈曲强度校核结果均满足规范要求。文中所得结论对潮流电站载体的设计具有参考意义。