寒冷地区隧道温度场的变化规律

为了揭示隧道温度场的变化规律,以某寒冷地区公路隧道为依托,选择11个测试断面,对隧道拱顶、拱腰、边墙和路面四个部位的温度进行1.5a的长期测试,采用正弦函数回归法,对测试数据进行分析。结果表明:隧道洞内的年气温变化具有周期性,随时间大致呈正弦曲线变化;隧道内纵向气温随着进入隧道距离的增大,年平均温度逐渐下降,年温度振幅也下降,其变化规律呈指数函数曲线变化关系;隧道围岩温度在径向一定范围内,随着径向深度的增加,年平均温度上升,年温度振幅衰减,并且呈指数函数曲线变化关系;防水夹层对隧道保温隔热是有利的。     

5羟色胺受体可塑性在大鼠肠易激综合征中的作用

目的探讨5羟色胺(5-HT)以及5-HT3、5-HT4受体可塑性在肠易激综合征(IBS)不同亚型发病中的作用。方法成年雄性SD大鼠27只,随机分为IBS合并腹泻组(IBS-D)I、BS合并便秘组(IBS-C)和空白对照组。分别采用乙酸灌肠、冰水灌胃的方法制备IBS-D和IBS-C大鼠模型。用5-HT以及5-HT3、5-HT4受体抗体的免疫组化方法检测各组大鼠肌间神经丛的5-HT及其受体数量的变化。结果①大鼠肌间神经丛5-HT阳性肠神经元数目IBS-D组(4.37±0.88)显著高于对照组(2.99±0.41,P<0.01),而IBS-C组(3.04±0.35)和对照组相比无差异(P>0.05);②大鼠肌间神经丛5-HT3受体免疫组化染色的灰度值各组间差异无统计学意义(F=0.082,P=0.922);③大鼠肌间神经丛5-TH4受体免疫组化染色的灰度值IBS-D组(141.98±6.96)显著低于对照组(159.90±2.55,P<0.01),而IBS-C组(155.62±2.03)与对照组差异无统计学意义(P>0.05)。结论大鼠肠肌间神经元内的5-HT含量及5-HT4受体数量的显著增多可能与IBS-D大鼠的发病相关。     

Relationship between the acid-suppression efficacy of proton pump inhibitors and CYP2C19 genetic polymorphism in patients with peptic ulcer

Obiective To investigate acid-suppression efficacy of proton pump inhibitors(PPls) in relation to CYP2C19 genetic polymorphism on patients with peptic ulcer. Methods By an open, randomized and control trial, fifty nine patients with active peptic ulcer were randomly assigned to receive one of three PPIs on a single dose (20 mg of each drug): omeprazole group (n=19), rabeprazole group (n=20) and esomeprazole group (n=20). lntragastric pH was recorded 1 hour before and 24 hours after administration. CYP2C19 genotype was tested in all patients. Resuits The EMs/PMs ratio of each group was 16/3,17/3 and 17/3, respectively. The total time that intragastric pH＞4, time percent pH＞4 and median pH in PMs patients were significantly higher than those in EMs patients of omeprazole group (P＜0.05). But all these differences were not found in rabeprazole group and esomeprazole group. The pH of nocturnal acid breakthrough (NAB) in both rabeprazole group and esomeprazole group was higher than that of omeprazole group, while there was no significant difference between rabeprazole group and esomeprazole group. Gonclusion The acid-suppression efficacy of omeprazole is highly dependent on CYP2C19 genetic polymorphism, while CYP2C19 genetic polymorphism may have a little influence on the acid-suppression efficacy of rabeprazole and esomeprazole. The acid-suppression action of rabeprazole and esomeprazole is superior to omeprazole, especially on night acid secretion.     

俄罗斯反水雷舰艇及装备发展给我们的启示

以俄罗斯反水雷舰艇为研究对象,介绍了俄罗斯反水雷舰艇及装备的发展过程及现状。借鉴俄罗斯发展反水雷舰艇的成功经验,吸取其先进的反水雷理论思想和技术,对我国反水雷舰艇的发展是非常必要和极其有益的。     

钢盖板临时路面体系在上海地铁7号线常熟路站中的应用

为尽量减少明挖法施工地铁车站在施工期间对现状地面交通的影响,上海地铁7号线常熟路站借鉴日本地铁车站施工中采用的较为成熟的钢盖板临时路面体系施工经验,结合本站的具体特点,采用了一种改进了的盖挖法施工钢盖板临时路面体系.文章全面介绍了该体系的设计,对今后类似工程有一定参考价值.     

富星桥预应力连续箱梁桥的设计

该文介绍了富星桥主桥的设计特点,该主桥为跨径40m＋70m＋40m的变截面预应力混凝土连续箱梁桥,箱宽20．75m,可供桥梁专业人员参考。     

三店塘大桥系杆拱桥设计

该文介绍了三店塘大桥主桥的设计特点,该主桥为跨径80m的下承式梁拱组合体系钢管混凝土拱桥,采用少支架的先拱后梁法施工,不影响河道的正常通航。     

真空断路器温升模拟与散热设计

温升对断路器的性能有着重要影响,是断路器设计时重点考虑的指标之一。笔者以某型10k V/5k A的真空直流断路器作为研究对象,通过热电耦合法对其进行了温度场数值模拟,与温升试验结果高度吻合。此后,探讨了散热器的配置位置以及强迫风冷方式对该型断路器温升分布的影响,最后提出了针对该断路器行之有效的温升改善措施。本文对真空断路器的散热设计有一定的参考意义。     

Modeling of ship maneuvering motion using neural networks

In this paper, Neural Networks (NNs) are used in the modeling of ship maneuvering motion. A nonlinear response model and a linear hydrodynamic model of ship maneuvering motion are also investigated. The maneuverability indices and linear non-dimensional hydrodynamic derivatives in the models are identified by using two-layer feed forward NNs. The stability of parametric estimation is confirmed. Then, the ship maneuvering motion is predicted based on the obtained models. A comparison between the predicted results and the model test results demonstrates the validity of the proposed modeling method.     

An elastic-plastic iceberg material model considering temperature gradient effects and its application to numerical study

To simulate the FPSO-iceberg collision process more accurately, an elastic-plastic iceberg material model considering temperature gradient effects is proposed and applied. The model behaves linearly elastic until it reaches the ‘Tsai-Wu’ yield surfaces, which are a series of concentric elliptical curves of different sizes. Decreasing temperature results in a large yield surface. Failure criteria, based on the influence of accumulated plastic strain and hydrostatic pressure, are built into the model. Based on published experimental data on the relationship between depth and temperature in icebergs, three typical iceberg temperature profiles are proposed. According to these, ice elements located at different depths have different temperatures. The model is incorporated into LS-DYNA using a user-defined subroutine and applied to a simulation of FPSO collisions with different types of iceberg. Simulated area-pressure curves are compared with design codes to validate the iceberg model. The influence of iceberg shape and temperature on the collision process is analyzed. It is indicated that FPSO structural damage not only depends on the relative strength between the iceberg and the structure, but also depends on the local shape of the iceberg.