Inhibitory action of docetaxel on the proliferation of HeLa and SiHa cells

Objective To study the inhibitory action of docetaxel (DOC) on the proliferation of HeLa and SiHa cells. Methods Cell morphological changes were observed with inverted phase contrast microscope. MTT was adopted to test and calculate the cell inhibition ratio. Flow cytometry was used to detect cell cycle. Results DOC had an obvious concentration-dependent inhibitory effect on the proliferation of both HeLa and SiHa cells. The inhibition ratio of DOC on SiHa was significantly higher than that on HeLa (P<0.05). DOC blocked HeLa at G2/M phase. Under the effect of DOC, the cell cycle of SiHa was not changed much. Conclusion DOC has an obvious inhibitory action on both HeLa and SiHa cells, which shows a promising prospect of DOC in clinical treatment of cervical cancer.     

采用马歇尔设计方法对旧沥青混合料进行热再生设计研究

该文介绍利用马歇尔试验方法进行旧沥青混合料热再生的设计研究,并对再生沥青混合料的路用性能进行了检测。     

223省道岩质高陡边坡稳定性的分析评价

针对广东省道223线岩质高陡边坡的稳定性问题,从其地形地貌、地层岩性、岩体结构等方面论证了对边坡稳定性的影响,并结合岩体质量分级及赤平极射投影法,对边坡的稳定性进行定性的工程地质分析。结果表明：岩质边坡整体上是稳定的,但应注意局部稳定性问题。     

基于仿真分析的汽车侧翻风险研究

侧翻事故是汽车产品缺陷可能引发的一种典型风险.文中应用ADAMS软件建立仿真模型,模拟车辆侧翻事故过程以研究其发生机理,并通过正交试验分析了侧翻风险与其主要影响因素之间的关系.     

Application of support vector machine to ship steering

System identification is an effective way for modeling ship manoeuvring motion and ship manoeuvrability prediction. Support vector machine is proposed to identify the manoeuvring indices in four different response models of ship steering motion, including the first order linear, the first order nonlinear, the second order linear and the second order nonlinear models. Predictions of manoeuvres including trained samples by using the identified parameters are compared with the results of free-running model tests. It is discussed that the different four categories are consistent with each other both analytically and numerically. The generalization of the identified model is verified by predicting different untrained manoeuvres. The simulations and comparisons demonstrate the validity of the proposed method.     

Computation of the viscous hydrodynamic forces on a KVLCC2 model moving obliquely in shallow water

The viscous hydrodynamic force and moment on ships moving obliquely in shallow water axe important for ship navigation safety. In the paper, the viscous flow field around a KVLCC2 model moving obliquely in shallow water is simulated and the hydrodynamic drag, lateral force and yaw moment acting on the hull are obtained by a general purpose computational fluid dynamics (CFD) package FLUENT with shear-stress transport (SST) k-w turbulence model. The numerical computation is performed at different drift angels and water depths. The numerical results are compared with experimental results, and a good agreement is demonstrated.     

ABS“V模式”开发中的快速控制器样件制作和硬件在环仿真的研究

分析了制动过程的车辆动力学特性,建立了车辆系统模型和ABS控制器模型.遵循"V模式"开发流程,在Matlab/Simulink和dSPACE开发环境下实现了汽车ABS控制系统的快速样件制造和硬件在环仿真.     

场桥吊具防摇装置的改进

对场桥吊具防摇装置进行改进,解决了电磁阀线圈易损坏、防摇钢丝绳易磨损、油缸出现内泄漏等问题,达到预期的改造目的。     

城市轨道交通乘客换乘决策因素分析

许多城市的轨道交通系统已经完成从单线运营到多线网络化运营的转变.伴随网络化发展而来的集中换乘客流,给轨道交通的规划建设与安全运营提出了挑战.以上海市轨道交通为例,通过对比手机信令与客流分配模型两种统计途径下的换乘客流差异,探究乘客换乘行为特征与换乘决策影响因素.将绕行换乘行为归纳为6类:高辨识度换乘车站、换乘不便捷车站...     

某新型轻卡转向系统模态对标及优化研究

转向系统模态控制是整车NVH开发的重要内容.文章针对某新型轻卡的怠速方向盘抖动问题,讨论了转向系统有限元模型的准确度影响因素,并与实测的方向盘频响曲线做对比.在模态及应变能分析结果上探讨了模态提升的主要方向,在此基础上优化转向系统主要部件,取得了较好效果.文章提供的转向系统模型对标及优化方法具有指导意义,对类似工程问题...