独墩单铰支座曲线梁桥通病分析及治理

针对目前独墩单铰支座曲线梁桥出现的通病 ,就温度对其梁体的变位影响以及预应力等因素对其支座支反力的作用进行了实例剖析。在此基础上探讨此类桥梁的支承体系的病害整治对策 ,并通过加固实例的监测结果予以验证     

汽车操纵动力学十八自由度模型仿真研究

本文介绍了根据多刚体动力学中的凯恩方法建立的一般两轴汽车的十八自由度数学模型。     

逆变器复合控制方案稳定性准确性和快速性的判定方法研究

本文针对重复控制加PI控制的复合控制方案,参照重复控制稳定性、准确性和快速性的判定方法总结出适用于复合控制方案的判定方法。并将重复控制器与复合控制方案的特性进行了对比,从理论上说明了判据的有效性。最后通过仿真进一步验证复合控制方案的判定方法。     

针片状指数对道砟直剪力学特性的影响

为研究针片状道砟在破碎情况下对道砟散体直剪力学特性的影响，通过进行不同工况下道砟直剪试验，从道砟散体剪切强度、变形及破碎特性对试验结果进行分析. 研究结果表明:（1） 随着针片状指数增加，道砟散体直剪力学性能下降，包括抗剪强度和内摩擦角（100 kPa下当针状指数由0分别提高到20%、40%时，抗剪强度分别降低10.9%、16.8%；片状指数由0分别提高到20%、40%时，抗剪强度分别降低14.7%、22.3%；针、片状道砟总值由0分别提高到20%、40%时，抗剪强度分别降低12.4%、18.9%）. （2） 随着针片状道砟含量增加，试样剪缩和剪胀量均降低. （3） 针片状道砟在直剪试验过程中易于发生破碎，且破碎类型多为整体断裂并伴随尖角破碎折断，显著影响有砟道床维修周期.      

海洋核动力平台电力系统设计概要

中国正在进行的海洋核动力平台国家示范工程项目,其电力系统设计存在着新的问题。本文以海洋核动力平台的需求为立足点,充分兼顾核电站的设计要求以及船舶入级的要求,归纳了适用于海洋核动力平台电力系统设计的要点,对海洋核动力平台的工程设计和新标准规范的制定具有较强的参考意义。     

钢棒加强式轨枕道床的纵横向阻力试验研究

为了探究钢棒加强式轨枕的纵横向阻力机理、分担以及钢棒插入深度和砟肩宽度的影响规律，为川藏铁路长大坡道韧性和稳定性增强提供新方法，通过进行一系列纵横向阻力试验得到了钢棒加强式轨枕纵横向阻力的总体特性和分担情况；通过改变钢棒插入深度和砟肩宽度探究了两者对钢棒加强式轨枕纵横向阻力的影响规律. 结果表明:与普通轨枕相比，钢棒加强式轨枕的纵横向阻力都有提高，当砟肩宽度为500 mm，堆高为0，钢棒插入深度为400 mm时，钢棒加强式轨枕纵横向阻力比肩宽为500 mm、堆高为150 mm条件下普通轨枕分别高39.2%和53.7%，枕底部分横向阻力分担比普通轨枕提升8%，纵向阻力提升26%；钢棒插入深度对道床阻力影响较大，在砟肩宽度为500 mm、堆高为0 时，插入深度由100 mm变至400 mm，相较于普通轨枕肩宽为500 mm、堆高为150 mm的工况，纵向阻力增幅由5.1%变至39.2%，横向阻力增幅由6.1%变至53.7%；砟肩宽度变化时，纵向阻力变化较小，横向阻力变化较大.      

STX4型驮背多功能运输车车体制造工艺

介绍了STX4型驮背多功能运输车的主要结构特点,分析了车体制造过程中的控制要点和难点,同时对制造难点提出了应对措施,有效保证了STX4型驮背多功能运输车的制造质量。     

The role of interleukin-8 produced by tumor induced fibroblasts in the development of cutaneous melanoma

Objective To determine the role of interleukin-8 (IL-8) produced by tumor induced fibroblasts in the development of cutaneous melanoma. Methods B16 melanoma cells induced L929 fibroblasts phenotype was transdifferentiated to myofibroblasts (MF) by co-culture in vitro. MF was monitored by morphology and immunophenotype for a-SMA. The level of IL-8 was detected by ELISA. The effect on B16 cell proliferation rate was estimated using MIT method in vitro. Melanoma implanting model was constructed in C57 mice. Results L929 MF phenotype could be modulated by B16 melanoma cells-derived transforming growth factor-β1 (TGF-β1) and elevated the levels of IL-8. L929 MF did not influence the B16 melanoma cells viability in vitro, but shortened the time of tumor formation and increased the incidence rates of tumors in C57 implanting model mice. Conclusion Fibroblasts can be activated by tumor cells and produce IL-8, which acts as an inflammatory cytokine promoting the development of cutaneous melanoma.     

Effect of ABCA1-V771M polymorphism on plasma lipid levels and its relationship with coronary atherosclerotic heart disease

Objective To explore the risk association of ABCA1-V771M polymorphism with coronary heart disease (CHD) in Hart nationality in Northwest of China. Methods With case-control study, ABCA1-V771M polymorphism was detected in 204 unrelated Hart nationality people in Northwest of China, and all the subjects by coronary angiography were grouped into 106 cases and 98 controls. The genotypes and alleles frequency distribution of ABCA1-V771M polymorphisms were analyzed by PCR-RFLP analysis, and the clinical statistics of serum lipids were compared and its effects of ABCA1-V771M polymorphism on the plasma lipid levels and coronary atherosclerotic heart disease were analyzed. Results The genotypic frequencies of ABCA1-V771M polymorphism matched well under Hardy-Weinberg equilibrium (P>0.05), V and M allelic frequencies were 33.3% and 66.7%. In comparison with VV VM genotype carriers, MM genotypes carriers had much lower plasma levels of HDL-C (P<0. 001) and much higher plasma levels of TG (P<0. 05). M allelic frequency in CHD group was significantly higher than V allelic frequency (P<0. 05). M allele was related with more severity of atherosclerosis in the coronary artery than V allele (P<0.05). However, there was no obvious difference in the incidence of AMI among carriers with three genotypes of ABCA1-V771M polymorphism (P>0.05). Conclusion ABCA1-V771M polymorphism was not only associated with the plasma levels of HDL-C and TG, but also related to the susceptibility and severity of coronary atheroselerotic heart disease. Moreover, M771 allele appeared to be atherogenie among Han population in Northwest of China.     

沙棘果油及沙棘籽油对大鼠放射性皮肤损伤的影响

目的观察沙棘果油及沙棘籽油对大鼠放射性皮肤损伤的影响。方法实验用深部X线治疗机,每次以3000 cGy的剂量,照射两次,造成大白鼠臀部放射性皮肤损伤。待动物症状明显后,将Ⅱ度皮肤损伤的动物随机分为6组,即阴性对照组、沙棘果油高剂量组、沙棘果油低剂量组、沙棘籽油高剂量组、沙棘籽油低剂量组以及阳性对照组。沙棘果油及籽油高剂量组,每天在损伤部位涂药两次,而其低剂量组每天涂药一次,阴性对照组每天涂灭菌的注射用水一次,阳性对照组每天涂Solcoseryl-Jelly软膏一次。结果肉眼观察结果显示,连续用药10d后,沙棘果油、籽油及Sol-coseryl-Jelly组动物的局部红斑、水肿明显减轻,创面分泌物明显减少,用药2周后,上述症状明显消退,与阴性对照组比较,明显好转;另外,沙棘果油、籽油及Solcoseryl-Jelly组的创面愈合时间明显缩短。光学显微镜观察结果显示,沙棘果油、籽油及Solcoseryl-Jelly组的皮肤损伤明显减轻,炎症反应亦明显减轻,创面修复明显。电子显微镜观察结果显示,阴性对照组的超微结构明显受损,而沙棘果油、籽油及Solcoseryl-Jelly组的损伤明显减轻。结论沙棘果油及沙棘籽油对大鼠放射性皮肤损伤有明显的治疗作用。