海洋核动力平台电力系统设计概要

中国正在进行的海洋核动力平台国家示范工程项目,其电力系统设计存在着新的问题。本文以海洋核动力平台的需求为立足点,充分兼顾核电站的设计要求以及船舶入级的要求,归纳了适用于海洋核动力平台电力系统设计的要点,对海洋核动力平台的工程设计和新标准规范的制定具有较强的参考意义。     

高职高专中药炮制技术课程数字化教学资源的构建与运用——以郑州铁路职业技术学院中药专业为例

数字化信息化教学模式已经逐渐发展为高职高专教学的主流,为了适应数字化信息化教学模式的变化,郑州铁路职业技术学院依托信息化教学平台,通过构建中药炮制技术课程数字化资源,建设了微课、PPT、在线题库等数字资源,以线上线下相结合的混合教学模式,激发了学生学习的积极性和热情,丰富并提高了师生互动的方式和频率,达到了提高教学质量的目的。     

The role of interleukin-8 produced by tumor induced fibroblasts in the development of cutaneous melanoma

Objective To determine the role of interleukin-8 (IL-8) produced by tumor induced fibroblasts in the development of cutaneous melanoma. Methods B16 melanoma cells induced L929 fibroblasts phenotype was transdifferentiated to myofibroblasts (MF) by co-culture in vitro. MF was monitored by morphology and immunophenotype for a-SMA. The level of IL-8 was detected by ELISA. The effect on B16 cell proliferation rate was estimated using MIT method in vitro. Melanoma implanting model was constructed in C57 mice. Results L929 MF phenotype could be modulated by B16 melanoma cells-derived transforming growth factor-β1 (TGF-β1) and elevated the levels of IL-8. L929 MF did not influence the B16 melanoma cells viability in vitro, but shortened the time of tumor formation and increased the incidence rates of tumors in C57 implanting model mice. Conclusion Fibroblasts can be activated by tumor cells and produce IL-8, which acts as an inflammatory cytokine promoting the development of cutaneous melanoma.     

Effect of ABCA1-V771M polymorphism on plasma lipid levels and its relationship with coronary atherosclerotic heart disease

Objective To explore the risk association of ABCA1-V771M polymorphism with coronary heart disease (CHD) in Hart nationality in Northwest of China. Methods With case-control study, ABCA1-V771M polymorphism was detected in 204 unrelated Hart nationality people in Northwest of China, and all the subjects by coronary angiography were grouped into 106 cases and 98 controls. The genotypes and alleles frequency distribution of ABCA1-V771M polymorphisms were analyzed by PCR-RFLP analysis, and the clinical statistics of serum lipids were compared and its effects of ABCA1-V771M polymorphism on the plasma lipid levels and coronary atherosclerotic heart disease were analyzed. Results The genotypic frequencies of ABCA1-V771M polymorphism matched well under Hardy-Weinberg equilibrium (P>0.05), V and M allelic frequencies were 33.3% and 66.7%. In comparison with VV VM genotype carriers, MM genotypes carriers had much lower plasma levels of HDL-C (P<0. 001) and much higher plasma levels of TG (P<0. 05). M allelic frequency in CHD group was significantly higher than V allelic frequency (P<0. 05). M allele was related with more severity of atherosclerosis in the coronary artery than V allele (P<0.05). However, there was no obvious difference in the incidence of AMI among carriers with three genotypes of ABCA1-V771M polymorphism (P>0.05). Conclusion ABCA1-V771M polymorphism was not only associated with the plasma levels of HDL-C and TG, but also related to the susceptibility and severity of coronary atheroselerotic heart disease. Moreover, M771 allele appeared to be atherogenie among Han population in Northwest of China.     

沙棘果油及沙棘籽油对大鼠放射性皮肤损伤的影响

目的观察沙棘果油及沙棘籽油对大鼠放射性皮肤损伤的影响。方法实验用深部X线治疗机,每次以3000 cGy的剂量,照射两次,造成大白鼠臀部放射性皮肤损伤。待动物症状明显后,将Ⅱ度皮肤损伤的动物随机分为6组,即阴性对照组、沙棘果油高剂量组、沙棘果油低剂量组、沙棘籽油高剂量组、沙棘籽油低剂量组以及阳性对照组。沙棘果油及籽油高剂量组,每天在损伤部位涂药两次,而其低剂量组每天涂药一次,阴性对照组每天涂灭菌的注射用水一次,阳性对照组每天涂Solcoseryl-Jelly软膏一次。结果肉眼观察结果显示,连续用药10d后,沙棘果油、籽油及Sol-coseryl-Jelly组动物的局部红斑、水肿明显减轻,创面分泌物明显减少,用药2周后,上述症状明显消退,与阴性对照组比较,明显好转;另外,沙棘果油、籽油及Solcoseryl-Jelly组的创面愈合时间明显缩短。光学显微镜观察结果显示,沙棘果油、籽油及Solcoseryl-Jelly组的皮肤损伤明显减轻,炎症反应亦明显减轻,创面修复明显。电子显微镜观察结果显示,阴性对照组的超微结构明显受损,而沙棘果油、籽油及Solcoseryl-Jelly组的损伤明显减轻。结论沙棘果油及沙棘籽油对大鼠放射性皮肤损伤有明显的治疗作用。     

护栏高度变化对防撞能力影响研究

护栏高度由于路面加铺罩面而降低,使得其安全防护性能受到影响。利用LS-DYNA有限元分析软件对不同高度下波形梁护栏进行了碰撞仿真实验,量化分析了护栏高度降低与其安全防护能力关系,确定了护栏防撞性能不能满足规范要求的临界高度值。对沿海高速公路原有护栏提出改造方案,并运用计算机仿真证明其符合规范规定。     

我国载人深渊器的发展策略及当前进展

文中简要介绍了载人深渊器的概念;阐述了我国研制载人深渊器的意义;总结了"蛟龙号"的经验与启示;提出了我国载人深渊器的发展策略并综述了目前所取得的进展.     

小汽车限行政策实践评述与反思

为解决小汽车保有量增加过快引发的交通相关问题,国内外许多城市开始实施限行政策.本文梳理总结了国内外城市限行政策的演化进程,发现尽管限行政策对缓解交通拥堵和改善空气污染有一定的作用,但不同城市的限行措施和限行效果也各有差异,出行者的一些规避限行的行为可能会对限行政策的实施效果产生一定的影响.     

集聚经济视角下轨道交通投资对城市系统均衡的影响

随着城镇化进程加快,城市规模增加所带来的集聚效应和交通拥堵等负外部性之间的矛盾越来越突出,优化城市交通基础设施建设是缓解该矛盾的重要举措。本文同时考虑了集聚经济和交通拥挤两种外部性,构建并求解了一个两区域城市空间结构模型,分三种情况探究了轨道交通的投资引入和道路容量的优化对城市规模和城市空间结构均衡的影响。结果表明,轨道交通的投资引入能够增加城市人口规模和社会福利,使城市结构更加紧凑。但是,随着集聚经济水平的提高,城市规划者应逐步完善公交配套设施,以降低公交拥挤成本,提高公交出行分担率;还应制定相应的福利政策,避免由于个体效用下降而导致人口流出。     

《汽车电子稳定系统》信息化教学设计

文章以高职汽车类专业平台课程《汽车构造》课程中的工作任务--《汽车电子稳定系统》教学设计为例,理论与实践相结合研究《汽车构造》课程信息化教学设计,从教学分析、教学策略、教学实施、教学反思四方面阐述设计过程,实际教学效果良好,教学特色鲜明,对信息化教学的推广,具有启示与借鉴意义。