SSRIs抗抑郁药治疗首发重性抑郁症患者前后双侧额叶和海马1H-MRS的分析

目的利用质子磁共振波谱分析(1H-MRS)探讨首发重性抑郁症患者脑部神经生化物质的变化。方法利用1H-MRS测量21例首发重性抑郁症患者双侧额叶、海马N-乙酰天门冬氨酸(NAA)、谷氨酸复合物(Glx)、胆碱复合物(Cho)、肌酸(Cr)和肌醇(mI)水平,计算NAA/Cr、Glx/Cr、Cho/Cr、mI/Cr,并与21例正常对照者(对照组)进行比较。选择性5羟色胺再摄取抑制剂(SSRIs)抗抑郁治疗3个月后再次比较病例组治疗前后NAA/Cr、Glx/Cr、Cho/Cr、mI/Cr的变化。结果治疗前病例组左侧额叶NAA/Cr、右侧额叶Glx/Cr、NAA/Cr及左侧海马Glx/Cr、NAA/Cr较对照组降低;右侧额叶和海马mI/Cr较对照组升高;SSRI抗抑郁药治疗后病例组左侧额叶及海马NAA/Cr较治疗前升高,右侧额叶mI/Cr较治疗前降低。结论重性抑郁症的病理机制可能与神经功能障碍、谷氨酸系统及第二信使系统异常有关,抗抑郁剂的疗效可能与改善神经功能及调整第二信使系统功能失调有关。     

Research on temperature field and thermal stress of liquefied natural gas carrier with incomplete insulation

The insulation of membrane type liquefied natural gas (LNG) carrier is composed of plywood boxes filled with perlite. Within the service period, considering of the effects of load conditions, such as sloshing, wave load, it is possible to have some damage of the plywood box, leakage of perlite, and failure of the insulation box. LNG carrier without whole protection of effective insulation is dangerous. Hull structure is extremely fragile when exposed to ultra-low temperature. In order to solve these problems, firstly a study on insulation boxes’ character and work condition is carried out and some presuppositions of partial disabled insulation are put forward. Secondly the thermal system of LNG carrier is analyzed to find out an effective way to simulate the thermal action of close air between outer and inner hull. Then a calculation about temperature field and thermal stress is done by MSC/PATRAN&NASTRAN. At the end it is concluded that LNG carrier with incomplete insulation is dangerous and needs to be avoided.     

A novel tracking control approach for unmanned underwater vehicles based on bio-inspired neurodynamics

A novel hybrid control approach is presented for trajectory tracking control of unmanned underwater vehicles in this paper. The kinematic and dynamic controllers are integrated by the proposed control strategy. The paper has two objectives. Firstly, an improved backstep method is proposed to generate the virtual velocity using a bio-inspired neurodynamics model in the kinematic controller. The bio-inspired neurodynamics model is intended to smooth the virtual velocity output to avoid speed jumps of the unmanned underwater vehicle caused by tracking errors and to meet the thruster control constraints. Secondly, a new sliding-mode method is added to the dynamic controller, which is robust against parameter inaccuracy and disturbances. The combined kinematic–dynamic control law is applied to the trajectory tracking problem of two different types of unmanned underwater vehicle. Finally, simulation results illustrate the performance of the proposed controller.     

岸电接地电阻仿真研究

本文根据建筑物接地时常用基础接地极方式减小接地电阻的经验,提出岸电接地装置接地极可以采用基础接地极方式。对基础接地极电阻进行ANSYS仿真计算,通过与垂直接地极电阻理论计算结果相对比,确定基础接地方式的可用性,并得到了码头接地装置和船壳之间不需要连接导体的结论。该研究将对码头接地装置接地极设计提供理论依据,为岸电系统运行安全性提供了保证。     

变频调速装置dv/dt滤波器设计

电力推进系统中采用变频调速装置供电时,PWM逆变器直接驱动电机会产生较高dv/dt电压,特别是当逆变器通过长线电缆与电机连接时,由于电缆中分布参数的影响,会在电机端产生电压反射现象,从而在电机端产生两倍以上的过电压,加速电动机绝缘老化,缩短使用寿命。本文在理论分析的基础上,提出了H桥逆变器、全桥逆变器dv/dt滤波器的设计方法,给出了设计实例,仿真与试验结果验证了设计方法正确性与有效性。     

城市慢行交通发展研究

低碳和谐是都市人对城市生活的渴求,而实现这种生活的一个关键就是城市交通的低碳和谐,即较低的城市交通工具尾气排放、通畅的城市交通运行,舒适、愉快的城市居民出行.文中通过对慢行交通系统的研究提出了一系列城市低碳型交通发展的新思路.     

向阳大桥主桥设计

向阳大桥上跨连云港港疏港航道,主桥为48m+80m+48m矮塔斜拉桥,采用塔梁固结、塔墩分离体系。文章从桥型方案比选结构设计、结构分析等方面对向阳大桥主桥的构造进行了阐述,可为同类桥梁的设计提供借鉴。     

沪杭甬高速公路拓宽工程通车状态下新老桥梁的拼接工艺

通过理论分析、荷载试验及施工措施的研究,确定沪杭甬高速公路拓宽工程中新旧桥梁拼接,特别是不同梁板形式的上部结构拼接设计、施工方案,减少工程施工对高速公路营运的影响,以满足大交通量高速公路畅通的要求.     

融雪剂的作用机理及危害分析研究

介绍了化学融雪剂的特征、主要成分以及作用原理。使用氯盐融雪剂对道路面和桥面具有较大破坏作用,对道路基础设施的使用寿命将产生消极影响。分析了其对生态环境的危害,提出了对路面桥面破坏作用少的新的除雪手段和使用新型融雪剂的建议。     

水平地震作用下高桩码头结构响应谱分析

以高桩码头一个结构段为研究对象,建立空间有限元模型,采用振型分解反应谱法探讨了此类结构在水平地震作用下的响应,对不同地震方向作用下码头桩基内力变化进行分析。计算结果表明:结构在纵向水平地震作用下叉桩桩顶弯矩明显大于横向水平地震作用下的桩顶弯矩;当码头桩基布置对纵轴不对称时,纵向水平地震作用下桩的扭矩较大;横向地震作用下,后叉桩的轴力较大。研究结果可为高桩码头的抗震设计提供参考。