Study on T lymphocyte subsets and NK cells in patients with Graves＇ disease combined with type 2 diabetes

Objective To investigate changes in T lymphocyte subsets and NK cells in patients with simple Graves' disease (GD)and Graves' disease combined with type 2 diabetes mellitus (GD/T2DM). Methods Fifteen cases of GD/ T2DM were selected from our hospital from November 2001 to November 2004. Before and after therapy thyroid function, thyroglobulin antibody (TGA), thyroid microsomal antibody (TMA) and blood glucose level were measured, and T lymphocyte subsets (CD3, CD4, CD8, CD4/CD8) and NK cells (CD56) were measured by immunofluorescence double labeling monoclonal antibody and flow cytometry, respectively. At the same time, comparison was made with simple GD (15 cases), T2DM (15 cases) and healthy control (20 cases). Results Before therapy, CD4/CD8, CD4 and NK cells in GD/T2DM were less than normal, and there was no significant difference in comparison with simple GD (P<0.05). In T2DM group, only CD4/CD8 and CD4 were less than those of healthy controls (P<0.05). When thyroid function recovered after 1 to 3 months of methimazole treatment in both GD/T2DM and simple GD groups, various indexes recovered, which were more obvious in simple GD. Conclusion Immune hypofunction of GD may be the key to the immune abnormality of GD/T2DM, which is more significant than that of simple GD or T2DM. The recovery of thyroid function and immune abnormality is not consistent, and the recovery of GD is more significant than that of GD/T2DM.     

基于ISO/IEC 9126的Web资源质量评测系统

为了管理基于Web的信息系统的资源质量,以国际软件质量管理标准（ISO／IEC9126）为基础,建立了Web资源质量评测系统,该系统包括多维多层次的Web资源质量评测模型（WebQM）、Web资源质量评测算法以及评测结果的鲁棒性分析,详细讨论了Web资源质量建模和应用TOPSIS算法评测Web资源质量的过程,鲁棒性分析主要研究了质量评测过程中评测参数取值对评测结果的影响,以优化Web资源质量模型和完善关键指标。     

连续性血液净化枸橼酸体外抗凝技术在高危出血患者中的应用

目的研究枸橼酸体外抗凝技术行连续性血液净化(continuous blood purification,CBP)的抗凝效果,解决高危出血倾向患者需行CBP时抗凝难的问题。方法32例高危出血倾向患者随机分为A、B两组,每组16例。均行CBP治疗,均采用枸橼酸抗凝剂为碱基的置换液。A组患者置换液输注速度为2 000 mL/h,血流量200 mL/min,枸橼酸浓度为13.3 mmol/L;B组置换液输注速度为4 000 mL/h,血流量250 mL/min,枸橼酸浓度为7 mmol/L。通过外周静脉补充钙剂。监测患者每日治疗前及结束时全血活化凝血时间(WBACT)、血气分析、血清离子钙及总钙水平。结果32例患者共行CBP治疗112次,总治疗时间1 238.3 h;置换液输入前WBACT与治疗前差异不显著,输入置换液后两组滤器后WBACT(s)较滤器前在2、4、6 h各时间点的延长均有显著性差异(P<0.01);治疗后患者碱剩余(BE)及pH无大幅度上升,无碱中毒出现;治疗前后血清总钙、离子钙水平无显著变化;不加重全身出血倾向,无其他严重不良反应。结论枸橼酸体外抗凝技术能解决高危出血倾向患者行CBP时抗凝难题。     

朝阳凌凤钢管混凝土拱桥静荷载试验

对朝阳的一座540m钢管混凝土拱桥,进行了通车前的静载试验,试验内容不仅包括常规荷载试验的拱肋截面、吊杆应力测试;跨中挠度测试;拱脚位移测试;还进行了平截面假定试验,了解了该桥在建成后的工作状态和安全承载能力。     

肋板式结构通道设计

从中岭立交工程通道设计出发,提出对于斜交角大于85°通道采用肋板式结构方案的设计特点。     

朝阳凌凤钢管混凝土拱桥静荷载试验

对朝阳的一座540m钢管混凝土拱桥，进行了通车前的静载试验，试验内容不仅包括常规荷载试验的拱肋截面、吊杆应力测试；跨中挠度测试；拱脚位移测试；还进行了平截面假定试验，了解了该桥在建成后的工作状态和安全承载能力。     

Experimental study on frictional and sealing performances of packing rings in an oil-free gas compressor

To enhance the reliability and to extend service life of packing rings, tribological and sealing performances are investigated based on the experimental results. Friction force, leakage rate and power consumption of three materials of pressure packing seals are measured in a refitted vertical gas compressor. The rings are made of common filled polytetrafluroethylene (Filled PTFE), PTFE reinforced with 30% mass fraction carbon fiber (30%CF+PTFE), and carbon-carbon composites infiltrated with PTFE (C/C+PTFE), respectively. It is found that packing rings will periodically vibrate with the periodic vibration of pressure packing after the travel direction of motion abruptly turns to the reverse direction. Furthermore, the amplitude of vibration slows down with the increasing crank angle. Approximate value of friction force is available by multiple-point fast Fourier transformation (FFT) employed to process the experimental results by reducing the impact of vibration to a great extent. Of three materials of rings employed in experiments, Filled PTFE presents minimal leakage rate accompanied with maximum power consumption. And 30%CF+PTFE exhibits minimum friction power and moderate leakage rate. As for C/C+PTFE, its high mechanical and thermal properties are favorable factors to enhance the ability of operating under high pressure and velocity and to improve the wear resistance. Unfortunately, this also leads to a large leakage rate. Comprehensive consideration should be taken into to evaluate the availability, reliability and service life for a type of packing ring under dry running conditions.     

车辆运行声车型自动分类的AR模型技术

利用AR参数模型提取采集到的车辆行驶时产生的车外噪声信号的特征,利用假设检验进行特征选择,并设计了BP神经网络进行分类识别.对道路现场采集到的2种车型共计110个信号进行分析,实验结果表明,通过AR参数模型提取车辆车外噪声特征实现车型自动分类是可行的,其分类的正确率达80% 以上.     

加强我军空中战略投送能力建设研究

针对我军空中战略投送能力薄弱的问题,结合我国国情、军情,研究提出了建立健全快速动员机制、增强民用运输机的军事适用性、发展军用运输机和创新战略投送模式等建议,可为我军空中战略投送能力建设提供参考。     

基于最小换乘模型的公交查询系统的设计与实现

设计并实现了含电子地图的公交查询系统,包括站点、线路和出行方案等3种查询方式.阐述了站站之间以"换乘次数最少为首要条件,站数最少为次要条件"的最优乘车路线算法:求出换乘矩阵,根据换乘矩阵计算得到经过站点的数目.实践表明系统具有较强的实用价值.