Comparison of the optimum designs of center pillar assembly of an auto-body between conventional steel and ahss with a simplified side impact analysis

This study compares the optimum designs of center pillar assembly with advanced high-strength steel (AHSS) to that of conventional steel for crashworthiness and weight reduction in side impacts. A simplified side impact analysis method was used to simulate the crash behavior of the center pillar assembly with efficient computing time. Thickness optimization aims to perform an S-shaped deformation of the center pillar toward the cabin to reduce the injury level of a driver in a crash test. Center pillar members were regarded as an assembly of parts that are fabricated with tailor-welded blanks, and the thickness of each part was selected as a design variable. The thickness variables of parts that have significant effects on the deformation mechanism were extracted as the main design variables for thickness optimization based on the results of a sensitivity analysis with design of experiments. The optimization condition was constructed to induce an S-shaped deformation mode and reduce the weight of the center pillar assembly. An optimum design was obtained after several iterations with response surface methodology (RSM). Optimization was first performed with conventional steel and then with AHSS with the same procedure to optimize the crashworthiness of the center pillar assembly. After thickness optimization, optimum designs were applied to the full vehicle analysis to evaluate the validity of the optimization scheme with the simplified side impact analysis method. Then, the crashworthiness of optimum designs with conventional steel and AHSS were compared using the full vehicle analysis. This comparison demonstrates that AHSS can be more effectively utilized than conventional steel to obtain a lightweight design of an auto-body with enhanced crashworthiness.     

轻轨车辆的制造

根据庞巴迪运输部德国车辆制造有限公司（ＤＷＡ）轻轨车设计开发、车体模型制作与试验等课题研究情况，进一步介绍如何实现车体轻量化结构、防撞击设计、防火安全及采用的先进的焊接技术。     

Numerical simulation on truncated oval-nosed projectile penetrating into stiffened plate北大核心CSCD

[Objectives]In this paper, the numerical simulation method is used to study the anti-penetration performance and energy absorption mode of a stiffened plate, as well as the influence of different stiffened bars on the flight attitude of the projectile body.[Methods] Finite element software LS-DYNA is used to simulate the process of a truncated oval-nosed projectile penetrating a stiffened plate, and the results of the numerical simulation are compared with an experiment to verify the reliability of the numerical simulation method. The momentum method and mass equivalence method are used to predict the residual velocity of the projectile, and the applicability of different theoretical methods within different velocity ranges is compared. The deformation energy of different regions of the stiffened plate is then extracted to analyze the influence of the initial velocity of the projectile body on the energy absorption mode of the target plate. Finally, the structure of the stiffeners is changed and the influence of the relative position of the stiffeners on the penetration attitude of the projectile body is analyzed.[Results]The results show that the mass equivalence method is more accurate than the momentum method in predicting the residual velocity of the stiffened plate when the initial velocity of the projectile body is in the range of 300–900 m/s. The ratio of the deformation energy of the stiffened plate to the energy loss of the projectile body decreases with the increase of the initial velocity of the projectile body. The effect of a T-stiffened plate on trajectory is greater than that of a rectangular-stiffened plate.[Conclusions]The related calculation method and research results have certain reference value for research and engineering application surrounding the anti-penetration of stiffened plates. © 2023 Chinese Journal of Ship Research. All rights reserved.     

襄阳汉江沉管隧道设计关键技术北大核心CSCD

基于襄阳汉江沉管隧道的工程设计实践,针对该隧道强冲刷、强透水地层深厚、防洪要求高等特点,对隧道平纵布置、管节及接头止水结构、干坞选型及结构、沉管基础及回填、沉管最终接头及对接端止水结构等进行了研究。结果表明:(1)内河沉管隧道采用长距离双轴线干坞布置方式,通过格形地下连续墙、超深落底式帷幕、地下连续墙预应力锚索垂直支护和混凝土封底组合技术解决了强透水地层深基坑支护及隔水难题;(2)采用全断面顺浇技术进行整体式管节预制,实现了管节接头止水设施的全国产化;(3)在内河沉管隧道采用高精度浮式整平先铺卵石基础,并提出了强冲刷区管顶防冲保护解决方案;(4)采用了不设独立止推构造的陆域最终接头,并针对工程需求设置了大直径锁口钢管桩配合外侧止水墙的对接端支护结构及分片整体吊装双壁钢围堰二次止水结构。     

肿瘤免疫研究的回顾与展望

20多年来,本校免疫病理研究室一直从事肿瘤免疫的研究,从研究肿瘤浸润淋巴细胞的活化和肿瘤逃逸的机制开始,到探索诱导浸润淋巴细胞(tumor infiltrating lymphocytes, TIL)活化的最佳条件,并将这些研究结果转化为肿瘤免疫治疗和免疫预防的实践,从一个侧面反映了人类在征服肿瘤道路上的艰苦历程。     

IAA与HRP联合作用对人胰腺癌BXPC-3的细胞毒效应

目的　研究吲哚乙酸(IAA)与辣根过氧化物酶(HRP)在体外共同作用于人胰腺癌BXPC 3 细胞所产生的细胞毒效应。方法　MTT法测定IAA/HRP对BXPC 3细胞增殖的影响;流式细胞仪分析BXPC 3 细胞周期时相变化;胎盘兰(曲利本兰)排斥试验,研究IAA/HRP对BXPC 3 细胞死亡率的影响;原位细胞凋亡检测试剂盒检测IAA/HRP作用后BXPC 3细胞的凋亡。结果　IAA/HRP体外对BXPC 3 细胞有抑制生长的效应,且这种效应有浓度和时间依赖性;BXPC 3细胞在IAA/HRP作用48 h后细胞周期被阻滞在G1期和G2期;IAA/HRP作用72 h后对照组和药物组的凋亡细胞数存在着显著性差异,且凋亡细胞数有浓度依赖性。结论　IAA/HRP对胰腺癌BXPC 3 细胞有细胞毒作用,可体外抑制细胞的增殖,诱导凋亡。     

萘乙酸抑制K562细胞增殖作用的初步研究

目的研究萘乙酸(NAA)对K562细胞增殖的抑制作用。方法应用MTT法、细胞计数法、流式细胞术、分裂指数分析、tunnel法以及姊妹染色单体交换(sister chromatid exchange,SCE)和微核制备,对NAA处理的K562细胞进行细胞增殖、细胞周期、凋亡以及染色体损伤检测。结果与对照组相比,NAA可以有效抑制K562细胞的生长,并将细胞阻滞在G1期,降低细胞分裂指数,促进细胞凋亡,提高K562细胞SCE频率以及微核形成率。结论NAA具有抑制K562细胞增殖的作用。     

新型EGFP标记的杆状病毒转移载体的构建及EGFP的制备

目的构建可表达增强型绿色荧光蛋白(EGFP)融合蛋白的昆虫杆状病毒转移载体,利用Sf-9细胞表达、制备EGFP。方法用PCR法从pEGFP质粒中扩增EGFP基因,NcoⅠ/SalⅠ双酶切,克隆入杆状病毒转移载体NcoⅠ/SalⅠ酶切位点之间,获得pFB-EGFP质粒;转化E.coliDH10Bac,通过转座子Tn7的介导,获得重组杆状病毒Ac-EGFP;感染Sf-9昆虫细胞;利用激光共聚焦显微镜和SDS-PAGE观察并检测EGFP的表达。非变性法纯化EGFP。结果荧光显微镜和激光共聚焦显微镜证实感染的Sf-9细胞可表达EGFP;通过SDS-PAGE获得的EGFP,大小为27ku。结论重组pFB-EGFP载体具备表达EGFP的能力,为分子生物学研究提供了一种新型可表达EGFP融合蛋白的昆虫杆状病毒表达载体。     

Galvanic corrosion behaviour of HE 20 / MDN 138 & HE 20 / MDN 250 alloys in natural seawater

In view of their excellent mechanical properties, workability and heat treatment characteristics, MDN 138 & MDN 250 have been widely used in missile, rocket and aerospace industries. With light weight and high performance characteristics HE 20 aluminium alloy acts as an important material in defence and aerospace applications. The galvanic corrosion behaviour of the metal combinations HE 20 / MDN 138 and HE 20 / MDN 250, with 1:1 area ratio, has been studied in natural seawater using the open well facility of CECRI’s Offshore Platform at Tuticorin for a year. The open circuit potentials of MDN 138, MDN 250 and HE 20 of the individual metal, the mixed potential and galvanic current of the couples HE 20 / MDN 138 and HE 20 / MDN 250 were periodically monitored throughout the study period. The calcareous deposits on MDN 138 and MDN 250 were analysed using XRD. The results of the study reveal that that HE 20 has offered required amount of protection to MDN 138 & MDN 250.     

Mathematical model for optimising the sequence for clearing snow from the manoeuvring area during winter operations

This article considers the optimisation of the sequence for clearing snow from stretches of the manoeuvring area of an airport. This issue involves the optimisation of limited resources to remove snow from taxiways and runways thereby leaving them in an acceptable condition for operating aircraft. The airfield is divided into subsets of significant stretches for the purpose of operations and target times are established during which these are open to aircraft traffic. The document contains several mathematical models each with different functions, such as the end time of the process, the sum of the end times of each stretch and gap between the estimated and the real end times. During this process, we introduce different operating restrictions on partial fulfilment of the operational targets as applied to zones of special interest, or relating to the operation of the snow‐clearing machines. The problem is solved by optimisation based on linear programming. The article gives the results of the computational tests carried out on five distinct models of the manoeuvring area, which cover increasingly complex situations and larger areas. The mathematical model is particularised for the case of the manoeuvring area of Adolfo Suarez Madrid—Barajas Airport. Copyright © 2016 John Wiley & Sons, Ltd.

Highlights
• Optimal sequence for clearing snow from the manoeuvring area of an airport.
• Contains optimising algorithms solved using CPLEX LP‐based tree search.
• Restrictions on partial fulfilment of operational targets applied to subsets of significant stretches, used for planning the operation of snow‐clearing machines.
• Model applied to the case of the manoeuvring area of Adolfo Suárez Madrid Barajas Airport.
• Conclusions are given on the results of the computational tests carried out. There are five models of the manoeuvring area which cover increasingly complex situations and larger areas.