低硒对心室肌纤维细胞动作电位的影响

用克山病区的粮食饲养大鼠,复制低硒动物模型、用浮置玻璃微电极技术,研究低硒大鼠在体心室肌细胞动作电位的变化,并与对照组进行了对比观察。结果发现低硒大鼠动作电位振幅明显降低(P<0.05),动作电位除极时限显著延长(P<0.01),而动作电位复极50%及90%的持续时间变化不显著(P>0.05)。实验结果说明低硒可明显影响大鼠心室肌细胞动作电位变化。为克山病心肌损害的病因学研究提供了重要的实验依据。     

A note on the interpretation of the dual variables in estimating traffic capacity at signal- controlled road junctions

The values of the dual variables in a constrained optimisation problem can be used to estimate the sensitivity of the optimal value of the objective function to changes in the constraints. Allsop (1972) used standard methods of linear programming to derive expressions for the sensitivity of the reserve capacity at a signal-controlled road junction to various changes in the traffic engineering constraints. That analysis used the assumption that the maximum reserve capacity would be achieved when the cycle time used is maximal. While this normally occurs, some junctions have come to light where a reduction in the cycle time increases the capacity. Allsop's analysis is extended here to account for this possibility.     

Rethinking maritime privatization in Africa

While recognizing the need for increased participation of the private sector in the maritime industry of developing countries, there is a need to go beyond the call for privatization in terms of mere change of ownership from state to private sector as the only solution to the inefficiency of the maritime industry in developing countries. This limited understanding of the maritime problems of these countries abounds in the literature on maritime privatization. This study departs from this approach and focuses on the political economy of the maritime industry, and suggests that maritime privatization will not necessarily result in increased efficiency of the divested maritime enterprises. Rather, it argues that maritime problems in these countries have less to do with ownership than with the structural constraints in world shipping together with internal management and local ~olitics. The maritime industrv in West and Central Africa is used as a case studv. and recommendations such as selective privatization, 'programme contract', and most importantly, corporatization, are suggested as alternative strategies that could enhance maritime privatization and the development of the maritime industry in developing countries.     

IN VITRO GLYCATION OF HEMOGLOBIN (HB):CHOOSING THE APPROPRIATE MODEL

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Cooperation in transit delivery in West German metropolitan areas

West Germany is densely populated, averaging 245 inhabitants/km², but varying widely between urban agglomerations and rural areas. Transport volume has increased by 40% since 1970, with virtually all growth due to private automobiles. Since 1981 public transit has been suffering from decreasing demand.A 1964 Expert's Report to the German federal government was the stimulus for initiating an effective funding mechanism for new public transit construction. In 1965 Germany's first federated transit authority was founded for the region of Hamburg.Principal among the goals of any cooperative agreement among transit companies are improvements for the passengers and improvement of revenues for the companies. To attain these ends, two distinct forms of transit aggrements have been developed in Germany: transit cooperative (Verkehrsgemeinschaft) and transit federation (Verkehrsverbund). The former is more suitable for smaller to medium-sized towns, while the latter is more suitable for larger cities. The two types are described in this article.German transit federations during the 1970s succeeded in significantly increasing ridership, while during the 1980s patronage has either remained steady or has declined. Yet transit federations showed much better perfomance than did public transit in general. In terms of costs and revenues, no public transit organization in Germany is able to break even; deficits vary between 42% and 55%. The author concludes, however, that hidden subsidies for automobile traffic are far higher, because of environmental damage and the high social cost of traffic accidents.     

The influence of personal security fears on women's travel patterns

This paper investigates the influence that women's fears and apprehension about attack and harassment have on use of transport facilities. After initial consideration of the factors that most affect perceived risk, the personal security aspects of different modes are reviewed by reference to a survey conducted in Southampton in 1986. High levels of perceived insecurity were found, particularly for walking at night, in parks and subways and when waiting for public transport services in isolated areas. The conclusions argue that personal security is an important but neglected issue, deserving of greater attention by transport planners.     

Stochastic Optimal Control of Highway Tractors with Active Suspensions

Stochastic optimal control and estimation theories are used to design an active suspension system for a cab ride in a tractor-semitrailer vehicle. A discrete-continuous vehicle model with eleven degrees of freedom is augmented by a stochastic road excitation model and a human perception of vibration shape filter. Both perfect measurement and estimated state cases are considered. The impact of the measurement noise on the design of the optimal controller is demonstrated. The performance of the optimally controlled system is compared with an optimal passive system. It is shown that significant improvements in ride comfort can be achieved through the use of actively controlled cab suspensions.     

Computer-Simulation of the Dynamical Curving Behaviour of a Railway-Bogie

This paper describes the modelling of a two axle railway-bogie with variable design configurations and its application in the investigation of the behaviour in transitional and circular curves. Several results indicate possibilities to improve the curving properties and recommend the usage of forced-steering bogies, which show better performance in narrow curves without unbearable sacrifices to high-speed-behaviour on straight track.     

Quantitative evaluation of passenger terminal orientation

When passenger terminal layout is being decided, one of the important aspects to consider is how the passenger orients himself during his visit to the terminal and his movements through it, i.e. terminal orientation. Among other things, this terminal characteristic results from visibility, or the visual connectivity between elements and spaces. The paper proposes an amendment and modification to the known method for the quantitative evaluation of terminal orientation which uses an oriented network to describe the connectivity of elements (terminal orientation). The amendment and modification of the method consists of proposing that during evaluation only visual connections that have functional meaning should be considered, rather than all visual connections. A further modification is the introduction of different weights for different connections. The example presented in the paper considers an airport terminal building.     

Privatisation and the quality of rail services

Using the concept of generalised costs to reflect quality in rail services, we consider the level of provision and quality of these services in the various forms they may take in a privatised environment within a model where we assume linear and separable demand and cost functions for analytical simplicity. Using the Pareto-efficient output and quality outcomes under a fully integrated system for reference (as well as those for a fully integrated profit-maximising monopolist) we show that if either bilateral monopoly or complementary monopoly emerge as a market structure the output of train services and their quality will generally fall. In the case of the emergence of both bilateral monopoly and complementary monopoly our analysis again suggests poor welfare outcomes. The implication that can be drawn from our analysis is that a regulator of a privatised rail system faces some severe problems if she is to attain the appropriate welfare targets.