Development of an intelligent CAE system for auto-body concept design

The concept design phase is a critical step in auto-body design, as it has a great effect on later design work. This paper describes the implementation of an auto-body structure design in the early stages of a new auto-body developing program. In order to reduce the long design period and analysis error that plagues traditional auto-body concept design, an intelligent CAE system has been successfully developed and implemented based on the UGS NX/API opening platform. This system, the so-called ACD-ICAE (Auto-body concept design-intelligent computer aided engineering) System that means concept design-intelligent computer aided engineering system, employs a fully parametrized template method to build the conceptual auto-body geometry model and FEM model quickly and easily. It also integrates auto-body modeling, analysis and optimization on only one CAD platform via a parametric variables database. Moreover, all parametric variables are shared and updated in different phases of the ACD-ICAE System. A wizard User Interface (UI) based on knowledge of auto-body engineering was developed and used in this system. The procedures implementing the functional diagram of the ACD-ICAE system are also provided. A typical example of a car body concept design with four doors shows that the ACD-ICAE system is efficient and accurate.     

基于GT—Power的汽车排气消声器性能分析及改进

利用GT-Power软件建立了某发动机工作过程与消声器的耦合仿真模型,得到消声器的插入损失和压力损失,仿真计算结果与试验结果基本一致,验证了该仿真模型的正确性.在保证压力损失不大于32 kPa的设计要求下,对消声器结构进行了局部改进.仿真结果表明,改进后消声器中高转速下的插入损失增加1～2 dB(A),较好地满足了该消声器的消声性能要求.     

汽车动力转向液压应急供油系统结构和原理分析

介绍了重型载货汽车动力转向中液压应急转向供油系统的组成、工作原理及主要元件的结构及功能.由于该液压应急转向供油系统具有电检测报警功能、对低速主转向供油的补充功能,在车辆动力转向失效或发动机停转等紧急状态下,仍能提供动力转向操作,从而进一步提高了车辆行驶的安全性.     

铁路钻探卡钻事故分析

卡钻是钻探中的一种事故,常易造成较大损失.文章从岩层、钻井液、钻探设备、施工因素方面分析了卡钻原因,提出了预防措施,并结合向莆铁路钻探中的卡钻事故进行了分析,总结了一些有意义的结论.     

低承载力地基重力式挡土墙墙踵台阶作用初探

在分析了重力式挡土墙特点的基础上,指出墙踵台阶能降低挡土墙对地基承载力的要求。采用岩土数值模拟软件FLAC^3D对无墙踵台阶和设置墙踵的重力式挡土墙的力学特征分析,确定设置墙踵台阶的挡土墙在低承载力地基使用的可行性理论依据。应用于实际工程证明,在低承载力地基重力式挡土墙设置墙踵台阶是合理、可行的。     

山区高速公路隧道结构型式模糊优选系统研究

基于模糊优选理论建立了隧道结构型式模糊优选系统。对系统自下而上进行求解,指标权重和定性指标的相对隶属度按二元对比法确定,成本型定量指标的相对隶属度按越小越优原则确定。实例分析表明,优选方法可行。     

通用腺伴随病毒载体的构建及表达报告基因GFP的实验研究

目的构建基因治疗通用型腺伴随病毒(AAV)载体并检测其转染外源基因作用。方法使用限制性内切酶切除pSSV9int质粒中的AAV病毒Rep和Cap基因元件后,插入了重组腺病毒专用穿梭质粒-pACCMVpLpA的含有CMV启动子、多克隆位点(MCS)和多聚腺苷酸信号(PolyA)的表达盒,构建了重组AAV通用载体质粒pSSHG-CMV。在该质粒MCS插入绿色荧光蛋白(GFP)基因后,使用pSSHG-CMV-GFP、GFP140和pAAV/Ad三种质粒共转染293包装细胞,制备GFP重组AAV。应用斑点杂交实验检测重组病毒滴度,并将该病毒感染新生大鼠NIH3T3细胞,荧光显微镜观察GFP表达。结果重组AAV的滴度在浓缩前可达2×1011cfu/mL,浓缩后可达2×1013cfu/mL,表明成功地构建了重组AAV载体。插入外源基因GFP后,在包装病毒和辅助质粒的联合作用下,能产生具有感染性的重组AAV。感染了重组GFP-AAV的大鼠NIH3T3细胞表达了明显的GFP荧光。结论构建的重组AAV通用载体pSSHG-CMV可转染外源基因,这为进一步的基因治疗奠定了基础。     

Correlation of expression of ER, PR and c-erbB-2 with ultrasonographic features in invasive ductal cancer of breast

Objective To analyze the relationship of the expression level of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER-2, c-erbB-2) of breast invasive ductal carcinoma (IDC) with ultrasonographic characteristics. Methods Totally 104 patients with IDCs confirmed pathologically were involved in this study. ER, PR and c-erbB-2 expression in the IDC specimens was determined by immunohistochemical staining technique. The correlation between the ultrasonographic features and the positive expression of ER, PR or c-erbB-2 was analyzed. Results The positive expression rate of ER and PR in the group with tumor spiculation sign and posterior acoustic attenuation was higher than that in the group without. The positive expression rate of ER differed significantly (P<0.05) while that of PR did not (P>0.05). The over-expression rate of c-erbB-2 in the group of microcalcification, sufficient blood flow and axillary lymph node metastasis was higher than that in the group of non-microcalcification, deficient blood flow or without axillary lymph node metastasis (P<0.05). The expression of ER, PR and c-erbB-2 was not related to the size of tumor (P>0.05). Conclusion The expression of ER and c-erbB-2 is closely related to the ultrasonographic characteristics of IDC, which may, to some extent, reflect the expression level of ER and c-erbB-2.     

基于TPA的管路振动贡献量分析

针对工程实际中管路振动贡献量难以定量分析的问题,引入传递路径分析法(TPA)。通过测量各路径的频率响应函数、各安装点和评估点的响应以及估算激励力,进行传递路径分析,进而得到设备与管路各自的贡献量。通过用某型海水泵进行实验,验证了该方法的准确性。实验结果表明,在40～200 Hz频段内,采用该方法得到的响应计算值与测量值误差小于3 dB,满足工程实际要求。     

黄芪蛰虫口服液对氢化可的松免疫抑制小鼠免疫功能的调节作用

目的研究黄芪蛰虫口服液对氢化可的松免疫抑制小鼠免疫功能的影响。方法50只昆明小鼠随机分为5组,每组10只。除正常对照组外其他4组建立氢化可的松(HC)免疫抑制动物模型,建模成功后用药3组分别按0.2、0.1、0.05mL/10g体重每天灌胃1次,10d后检测小鼠腹腔巨噬细胞活性、脾脏T淋巴细胞增殖转化能力、脾脏NK细胞活性、脾细胞产生抗体能力和IL-2的能力。结果不同剂量黄芪蛰虫口服液不同程度地提高HC免疫抑制小鼠的腹腔巨噬细胞吞噬活性、脾脏T淋巴细胞增殖转化能力、脾脏NK细胞的活性、脾脏产生抗体能力及IL-2能力的作用。结论黄芪蛰虫口服液具有提高HC免疫抑制小鼠的某些免疫功能。