移动闭塞系统配置后备系统设备方案质疑

从移动闭塞系统和后备系统构成以及后备系统使用时机分析，提出移动闭塞系统配置后备系统方案的不合理问题，建议新建移动闭塞系统取消此配置。     

信号系统车载设备的安全完整度及安全评估

文章系统地介绍了安全完整度的定义及实现过程,包括危险识别、风险分析、危险控制、安全完整度等级和安全完整度需求的分配和实现,并介绍了安全评估的基本要求和过程以及在信号系统车载设备的应用实例。     

论职业学校教师职业的专业化及其实现

解释了职业专业化的内涵,分析了我国职业学校和教师职业专业化的现状,论述了我国实现职业学校教师职业专业化的途径。     

论海事行政处罚自由裁量权的规范应用

随着船舶违法行为种类的不断增多,以及自由裁量权幅度的增加,如何运用好法律赋予的行政权力,在海事执法实践中体现国家意志和公正性,是海事执法人员必须思考的问题。文章介绍了目前海事部门行使自由裁量权的现状,并就如何规范自由裁量权的应用和监督落实提出了相关建议。     

Establishment of a uremic apolipoprotein E knockout mouse model to explore the mechanism of uremic atherosclerosis

Objective To establish a uremic apoE-/- mouse model to observe serum biochemical parameters and features of aortic root atherosclerosis (AS) in the model. Methods A uremic model was induced surgically in apoE-/- mice: electrocautery of the right kidney at 8 weeks of age and nephrectomy (NX) of the left one 2 weeks later. Control mice were sham-operated. Two weeks after NX, renal functions were detected in the uremic and control mice to evaluate the efficiency of the model. After 10 weeks of NX, blood samples were taken to determine serum biochemical parameters, and aortic root was collected for frozen sections to investigate the lesion features of AS. Results Two weeks after NX, renal functions declined significantly in the uremic mice compared with the control ones, and remained stable 8 weeks later either in males or in females. Ten weeks after NX, serum levels of TCH, TG and LDL-C were dramatically higher in the uremic mice than in the controls, whereas no differences in serum HDL-C or glucose concentration were found between the two groups. Aortic root plaque relative area increased significantly in the uremic mice compared with the controls either in males or in females; more-over, the lesion area was larger in female mice than in male ones. Conclusion We established a uremic apoE-/- mouse model successfully, and this model is characterized by accelerated atherogenesis which is associated with an increase in serum lipid profile. This experimental model can be a useful tool to study the pathogenesis and therapeutic strategies of uremic AS.     

汽车侧面安全性的优化设计

根据某车型的侧面碰撞试验结果，分析了该车侧面安全性存在缺陷的原因。应用所建立的经确证侧面碰撞仿真模型，仿真计算了所提出的提高侧面安全性的改进方案。结果表明，优化改进后，B柱变形模式趋于合理，汽车侧面变形量整体上有所减小；假人肋骨变形量减小了42.3％，腹部受力减小了35．8％，耻骨结合点Y向分力减小了19．6％。     

体外预应力桥钢索锚固区空间应力仿真分析

结合某高速公路体外预应力试验桥的设计,利用桥梁分析专业软件M IDA S/C iv il对该桥的钢索端部锚固区域进行了空间应力仿真分析,研究了关键区域的应力分布、受力特点。同时,基于分析结果,应用拉杆-压杆分析模型对该区域进行了相应的配筋设计,研究结论可供类似工程参考。     

粉煤灰对水泥稳定类基层材料性能改善的机理探讨

针对粉煤灰对水泥稳定类基层材料性能改善机理不够完善、不够系统以至水泥粉煤灰稳定类基层材料无法很好地进行推广应用的问题,从材料的组成、结构决定材料的性能的原理入手,通过分析探讨粉煤灰对水泥稳定类基层材料的微观与宏观结构组成、化学与材料组成以及力学参数等方面的改性,提出粉煤灰通过填充作用、活性作用、接触形式改善作用、微集料作用以及改善力学参数作用对水泥稳定类基层材料的性能进行改善,为水泥粉煤灰稳定类基层材料的设计与应用提供了相应的理论支持。     

明月山特长隧道涌水突泥综合处理措施

明月山隧道为具有多种不良地质的特长公路隧道,施工中发生了特大涌水、突泥灾害,造成严重坍塌事故。通过对隧道涌、突水灾害产生的原因及坍塌形态进行详细的分析研究,采取了一系列行之有效的处理措施,并对地表、洞身及坍塌体进行了固结和加固,快速而有效地完成了突泥及坍方段施工。文章介绍了隧道涌水、突泥灾害的概况和采取的综合处理措施。     

含砂低液限粉土路基冲击压实技术研究

针对含砂低液限粉土路用性能差,常规压实方法难以达到压实度要求等施工难题,采用冲击碾压技术进行路基补压试验,获取冲压遍数、冲压沉降量等施工控制参数。通过试验确定采用沉降与面波法进行冲压质量评价,为全线推广使用冲击压实技术提供技术保障。