基于AMFNN的非线性噪声消除器

提出基于加乘性模糊神经网络(AMFNN)的非线性噪声消除器，讨论了AMFNN模型和学习算法及其通用逼近性．该消除器利用AMFNN逼近噪声，然后从测量信号中消去噪声即得到有用信号．该噪声消除器具有神经网络分布式并行信息处理能力、较好的容错性和鲁棒性以及除噪性能．     

TSH RECEPTOR GENETIC ALTERATIONS IN THE AUTONOMOUSLYFUNCTIONING THYROID ADENOMAS

Objective To determine the relationship between TSH receptor gene mutations and autonomously functioning thyroid adenomas (AY‘]rAs). Methods The thyroid samples from 14 cases of diagnosed AFTAs were analyzed, with normal thyroid specimens adjacent to the tumors as controls. The 155 base pairs DNA fragments which encompassed the third cytoplasmic loop and the sixth transmembrane segments in the TSH receptor gene exon 10 were amplified by Polymerase chain reaction (PCR) and analyzed by the single-strand conformation polymorphism (SSCP). Direct sequencing of the PCR products was performed with Prism Dye Terminator Cycle Sequencing Core Kit.Results 6 of 14 AFTA specimens displayed abnormal migration in SSCP analysis. In sequence analysis of 3 abnormally migrated samples, one base substitution at nucleotide 1957 (A to C) and two same insertion mutations of one adenosine nucleotide between nucleotide 1972 and 1973 were identified. No mutations were found in controls. Conclusion This study confirmed the presence of TSH receptor gene mutations in AFTAs; both one-point substitution mutation and onebase insertion mutation were found to be responsible for the pathogenesis of AFTAs.     

THE STUDY ON THE CHANGES OF ZINC, COPPER, CALCIUM AND MAGNESIUM IN PLASMA AND ERYTHROCYTES DURING CARDIOPULMONARY BYPASS

Objective To study the changes and their influence factors involved of zinc, copper, calcium and magnesium in plasma and erythrocytes during cardiopulmonary hypass(CPB). Methods Zinc, copper, calcium and magnesium values in plasma and erythrocytes were measured by atomic absorption spectrophotometer during CPB. Results Zinc and copper levels in plasma were significantly elevated above preinduction level before perfusion, hut calcium and magnesium levels did not change significantly; zinc, copper and calcium levels in plasma were significantly below preoperation level during CPB, hut magnesium level in plasma was significantly increased above preoperation; zinc level in plasma was increased to preoperation level after CPB and began to decrease again at 8 hours after CPB,copper level in plasma was increased to preoperation level at 20 hours after CPB, calcium in plasma was increased significantly from beginning to 8 hours after CPB, magnesium level in plasma was decreased to preoperation level at 8 hours afterCPB. Concentration of zinc , copper, calcium and magnesium in erythrocytes did not change significantly. Conclusion During CPB, the changes of zinc, copper, calcium and magnesium had relation to hemodilution, operative wound, carrier protein, stress and component of priming Solution and cardioplegic solution, hut no relation to transferfrom plasma erythrocytes. The results indicate that it is beneficial to patient‘s recovery to supplement zinc, copper, calcium and magnesium properly by different ways during cardiac perioperation.     

EFFECTS OF FILTER MEMBRANES ADSORBING INFLAMMATORY MEDIATORS IN HEMOFILTRATION

Sepsisischaracterizedbyreleaseofexcessiveamountofproinflammatorycytokinesinthecircu lation ,leadingtoa generalizedanduncontrolledhostresponse .Aconsiderablenumberofexperimen talandclinicalinvestigatorshavereportedemploy inghemofiltration (HF)toeliminatecytokinesandchemokines .Thisexcessiveinflammatoryresponsecouldbedownregulatedwithremovalofcytokinesandothermediators .Thesedatashowedthatthemechanismofmediatorseliminationwaslinkedtoconvectionandadsorptionbyhemofiltration .Ad sorptionappearstob…     

MITOCHONDRIAL DNA POLYMORPHISM IN CONTROL REGION FROM CHINESE YUGU POPULATION

Objective To investigate the mitochondrial DNA sequence polymorphism sites in Chinese YUGU ethnic group and to provide basic data used in forensic purpose. Methods Genomic DNA was extracted from the hole blood of 100 unrelated individuals of Chinese YUGU ethnic group by standard chelex-100 method. The sequence polymorphism sites was determined by PCR amplification and direct sequencing. Results 54 polymorphic sites were noted in mtDNA np16091-16418 region, and 46 haplotypes were identified. The genetic diversity was calculated to be 0. 9691, and the genetic identity was calculated to be 0. 0406. Conclusion There are some particular polymorphism sites in Chinese YUGU ethnic group. The results suggest that sequence polymorphism from np]6091 -- 16418 in human mitochondrial DNA can be used as a biological marker for forensic identity.     

EXPRESSION OF NESTIN AND GLIAL FIBRILLARY ACIDIC PROTEIN IN DIFFERENT PERIOD AFTER SPINAL INJURY IN ADULT RATS

Objective To study the expression of Nestin and glial fibrillary acidic protein (GFAP) in different period after spinal injury in adult rats. Methods Animal moels were created by artery clamp. Expression of Nestin and GFAP in different period ( 1,3,5days; 1-8 weeks) and different area( injury locus and its surrounding tissue ) after spinal injury were observed pathologicaly using immunofluorescence and LeicaQ5001W imaging processing system.Results There was expression of Nestin and GFAP in injured area 1 day after injury. The expression increased not only in in injured area but its sourrounding 3--7 days later and gradually got to peak value. As the time went on, expression of Nestin and GFAP dereased. Conclusion Spinal injury can induce the expression of Nestin. Nerve stem cell has response to spinal injury. There is positive correlation between expression of Nestin and hyperplasia of reactivity astrocyte. Nerve stem cell maybe invovled in the repair of central nervous system (CNS).     

地铁列车在出站晚点情况下的"压赶结合"运行调整方法

针对地铁列车站停时间计划外延长所导致的“出站晚点”情况和基于“车站发到间隔”与“列车追踪间隔”的均衡目标,本丈论述后续列车站前“压点”运行与站后“赶点”运行相结合的应对策略的有效性及合理性,提出地铁列车“压点”运行过程中ATO模式曲线的实时调整方法,作为现行的“赶点”运行调整方法的扩充,优化随机客流的有效吸纳。     

干道主车流的分形描述和测度构成理论

本文对主干道主车流的形成过程进行了分形描述,提出了分形测度构成的具体步骤,给出了信号控制交叉口的主车流分形图形的定义,描述了主车流分形控制的理论基础。研究表明,用分型理论控制的交叉口在同一时间内可使车辆通过数量增加2～3倍,并创造良好的经济效益。     

城市交通状态的空间依赖性和异质性分析

有关城市交通状态空间特征的研究相对匮乏。从空间角度分析城市宏观交通特征,首先,针对城市路网几何形态和交通数据的关系提出适合于城市交通数据分析的空间模型。然后,以从长期的浮动车数据中提取的路段行程速度作为描述交通状态的实验数据,分别采用空间自相关和核密度估计法定量分析路网行程速度的空间依赖性和空间异质性,并分析其在典型时段的空间分布特征。结果显示:城市交通状态的关联性在空间上随着路段间距的增长而衰减;城市交通状态的空间分布特征随时间变化,受路网结构和区域功能的影响在空间中呈现集聚特征。     

基于振动成型法的抗裂水稳碎石关键技术研究及应用

基于振动成型法的抗裂型水稳碎石是一种以连续级配粗集料形成相互嵌挤骨架、用水泥及细料填充骨架空隙而形成的骨架嵌挤密实结构无机结合料。通过试验,分析了不同水泥剂量及4.75mm通过率对抗裂水泥稳定碎石强度的影响,并得到了4.75mm通过率及水泥剂量取值范围。依托某省道新建工程,研究了基于振动成型法的抗裂型水稳碎石配合比优化设计方法,并对现场施工关键要点进行了探讨。