用化学发光法进行兔体锌盐药代动力学的研究

本文采用化学发光技术,对兔体血浆中不同锌盐的吸收代谢状况,进行了跟踪监测,将测试结果输入计算机进行数据处理,效果满意。     

拱桥拱背加固减载法

拱桥拱背加固减载法是对传统拱桥加固中扩大截面加固法的创新和改造，结合湖北省三峡库区3号桥和福建省永安大溪桥的加固实例，分析拱桥拱背加固减载法的机理、特点和适用范围。     

套管咬合桩支护技术在地铁工程中的设计与应用

结合对全套管钻孔咬合桩关键技术的研究及其在南京地铁工程中的应用,分析该工法的综合优势和适用条件,首次提出无筋桩的刚度贡献按10%～20%考虑的建议,满足施工工艺要求的超缓凝混凝土配制方法;成功应用具有自主知识产权的国产液压套管桩机完成了一批深大基坑的施工,对地铁车站和类似的深基坑工程有指导意义     

Effects of intersection field of view on emergent collision avoidance performance at unsignalized intersections: analysis based on driving simulator experiments

Proper intersection sight distance can effectively lower the possibility of intersection accidents. American Association of State Highway and Transportation Officials (2011) provide a series of recommended dimensions of intersection sight triangles for uncontrolled and stop/yield‐controlled intersections. However, in reality, although the actual intersection design for unsignalized intersections satisfies the requirements of sight distance and clear sight triangle in American Association of State Highway and Transportation Officials' guideline, there are still a large number of crashes occurring at unsignalized intersections for drivers running stop/yield signs or failing to slow down. This paper presents a driving simulator study on pre‐crash at intersections under three intersection field of view (IFOV) conditions. The aim was to explore whether better IFOVs at unsignalized intersections improve their emergent collision avoidance performance under an assumption of valid intersection sight distance design. The experimental results show drivers' ability to identify potential hazards to be significantly affected by their IFOVs. As drivers' IFOV improved, drivers were more likely to choose braking actions to avoid collisions. Better IFOVs were also associated with significant increases in brake time to intersection and significant reductions in deceleration rate and crash rate, thus leading to a lower risk of traffic crash involvement. The results indicate that providing a better IFOV for drivers at intersections should be encouraged in practical applications in order to improve drivers' crash avoidance capabilities. Copyright © 2016 John Wiley & Sons, Ltd.     

国内各城市的轨道交通线网负荷强度比较分析——基于中国城市轨道交通协会数据分析的研究报告之二

统计了国内28座城市的轨道交通(不含市域铁路、磁悬浮线、机场线)线网负荷强度。结合各城市的线网规模、市区和主城区常住人口密度、单程通勤距离、线路开通运营时间、沿线区域开发情况等因素,分析了引起线网负荷强度差异的原因。总结了提升城市轨道交通线网运营效率的要点:在城市主城区,当常住人口密度达到一定程度时,宜优先建设城市轨道交通,并应尽量覆盖大客流集散点;在城市外围区域,当基于TOD(交通引导发展)模式引导城市轨道交通建设时,应确保城市轨道交通建设与沿线区域土地利用开发同步实施。     

组织工程活性真皮的构建研究

目的探讨用脱细胞真皮(ADM)、胶原海绵膜(SCM)、胶原凝胶构建活性真皮的可行性。方法从幼儿包皮中纯化、扩增成纤维细胞(Fb),将其分别种植于ADM、胶原凝胶、SCM上,观察细胞增殖及支架收缩等情况。结果Fb在ADM上不能成活;在SCM上增殖良好,人工真皮收缩不明显;在胶原凝胶中增殖活跃,但人工真皮收缩明显。结论利用SCM构建的人工真皮,是一种较理想的活性真皮。     

北豆根中粉防己碱的药物代谢动力学研究

粉防己碱是北豆根所含主要有效成分之一，为了解药动学和药效学的关系，本文选择灵敏度高，选择性强的胶束荧光法，研究了粉防己碱在兔体内的药代动力学。实验结果表明，粉防己碱是一种中速吸收，中速消除的药物，其几个主要药动学参数为ｔ１／２（α）为１．４ｈ，ｔ１／２（β）为５．１８７ｈ、ｔ１／２（Ｋａ）为１．３１４ｈ、Ｋ２１为０．４３１２ｈ－１、Ｋ１０为０．１５３４ｈ－１、Ｋ１２为０．０４４ｈ－１、ＡＵＣ为１０５．７μｇ·ｈ·ｍｌ－１。     

Ge－M_（10）抗癌药理试验研究

作者对中草药的有效成分与锗生成的锗化物（简称Ｇｅ－Ｍ１０），进行了系列药理试验，实验结果表明Ｇｅ－Ｍ１０具有水溶性好，腹腔注射１００ｍｇ／ｋｇ·ｄＧｅ－Ｍ１０，抑瘤率为６４．２％，口服１００ｍｇ／ｋｇ·ｄＧｅ－Ｍ１０，抑瘤率为５８．５％。药代动力学参数ｔ１／２（ｋａ）为１．１３ｈ，ｔ１／２（ｋｅ）为５．２３ｈ，Ｔ（ｐｅａｋ）为３．０５，Ｃ（ｍａｘ）为０．９８μｇ／ｍｌ，ＬＤ５０为７６１８ｍｇ／ｋｇ，经抗癌机理研究表明，Ｇｅ－Ｍ１０是一种良好的免疫性抗癌药物。     

灌浆法在加固处理软路基中的应用

介绍了肃临线衡水市外环路项目软土路基灌浆加固设计、施工、检测及效果。     

浅谈桥梁毛勒伸缩缝施工技术

毛勒伸缩缝是桥梁伸缩缝的一种新结构,安装工艺较复杂,技术要求高。对E标段在安装毛勒伸缩缝实践中,对D80B、D160B型毛勒伸缩缝槽口尺寸的控制,毛勒缝装置的吊装、安装、调整、钢筋焊接等工艺及毛勒缝伸缩量的计算和安装、解锁温度等作了介绍。