大鼠反复癫痫发作后心脏交感神经-β肾上腺素受体的表达变化

目的 观察大鼠反复癫痫发作后心室肌β受体mRNA表达水平的动态变化.方法 将20只健康SD大鼠随机分为4组,对照组、1周组、2周组和4周组.对照组大鼠只在头部植入电极,不给电刺激,其余各组用电休克诱发癫痫发作.在相应时间点处死大鼠,取左心室组织,用RT-PCR方法测定β1、β2受体mRNA的表达水平.结果 大鼠反复癫痫发作后β1受体mRNA的表达水平明显下降(P<0.05),β2受体mRNA的表达水平无明显变化.β2受体在β受体中所占比例由对照组的15%上升到癫痫反复诱发4周后的40%.结论 大鼠反复癫痫发作后心脏β2受体在β受体中所占比例逐渐升高.     

Association between the -1562 C/T polymorphism in the MMP-9 promoter and phenotype of esophageal squamous cell carcinoma in northern Chinese population

Objective To conduct a case-control study on the association of the nucleotide polymorphisms in the promoter region of the matrix metalloproteinase-9 (MMP-9) gene with phenotype of esophageal cancer. Methods All subjects were unrelated residents in northern regions of China. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was used to determine the MMP-9 genotypes. Results The overall distribution of genotypes in the patients was not different from that in the controls (OR=0.77, 95% CI=0.45-1.34; P=0.36). There were no significant differences between the patients and the control subjects in terms of the distributions of sex and age, smoking status, alcohol dependence, pickled diet status, or history of environmental exposure. The patients were further examined with stratifications by age, sex, grade, depth of tumor invasion, lymphatic invasion, venous invasion and TNM staging. The results showed no pronounced association among the stratifications. Conclusion There is no significant association between the MMP-9 single nucleotide polymorphism genotypes and phenotype of esophageal cancer.     

Histological changes following surgically-assisted rapid tooth movement through resistance reduction and distraction osteogenesis in dogs

Objective To investigate the histological changes of rapid tooth movement in dogs treated by resistance reduction and distraction osteogenesis, aiming to establish an animal model and further to reveal the remodeling mechanism of rapid tooth movement. Methods A total of 8 local hybrid dogs were selected as subjects for this study. The second pre-molar was extracted on both sides. The experimental side underwent alvelor surgery for resistance reduction and a home-made tooth-borne intraoral distraction device was installed for rapid tooth movement, while for the other side (control side) only tooth-borne intraoral distraction device was used for rapid tooth movement. The longest active force-delivery span was 2 weeks, followed by 6-week retention. The distance between the moved tooth and anchor unit was recorded weekly, and radiography was performed for each side before and after distraction. The surrounding tissues including periodontal ligament and alveolar bone were sectioned for histological analysis. Results The average distance of tooth movement was 3.55mm on the experimental side and 1.11mm on the control side. The rate of tooth movement was notably higher (P<0.01) and no significant apical root resorption was detected by X-ray on the experimental side. The active alvelor bone remodeling was found on the tension and pressure sides. However, there was no significant difference between the experimental side and the control side after the retention period. Conclusion The rate of orthodontic tooth movement can be accelerated through resistance reduction and periodontal distraction without any unfavorable effects but at minimal anchorage loss.     

高速公路慢速交通路段沥青混凝土配合比设计

针对慢速车道路段交通荷载的特点,从沥青原材料选择及级配优化设计入手,研究了慢速交通条件下抗车辙沥青混合料的设计方法,并对设计的沥青混合料抗永久变形性能进行分析和评价,提出慢速交通段沥青混合料的设计指标、设计参数。     

基于LabVIEW的电机振动数据分析平台

建立了基于LabVIEW的电机振动数据分析平台.该平台主要由频谱分析模块和时频分析模块两部分构成.通过频谱分析模块实现幅度谱、功率谱分析以及频率峰值计算;而时频分析模块可用来进行时间与频率联合分布强度的分析.将两组交流电机调速系统振动测试数据应用于该分析平台,测试结果表明:所建立的振动数据分析平台能够方便、有效地对振动测试数据进行频谱分析与图形显示,对测试数据中的干扰信号具有一定的处理功能,具有仪器化的人机界面,操作简单方便.     

中咀坡水电工程溢洪道水工模型试验研究

针对中咀坡水电工程的初设方案,探究工程在其洪水期运行阶段是否满足泄洪要求,泄洪隧洞底部是否会产生空蚀,破坏建筑物安全以及闸门调度等问题,建立水工物理模型。通过试验对工程溢洪道的泄流能力,泄水隧洞底部受压情况进行验证和计算;为保证电站正常运行,对于上游来水量较小的枯水期,拟定闸门调度方案。     

安全管理与监控监测信息系统设计与实现

安全管理与监控监测信息系统是集计算机网络技术、数字视频技术、自动化监测技术为一体的地铁工程建设安全风险管理信息系统.从系统的总体设计(包括系统总体构成,系统结构层设计、数据管理设计、数据流程设计以及业务总体设计)、功能实现以及应用效果分别进行详细介绍.     

截面转换法加固钢筋混凝土T形梁桥合理加固区段探讨

以承载能力极限状态结构设计理论为依据,在加固前建立一个关于加固区段的截面弯矩方程,通过求解方程来确立合理加固区段长度,并结合具体的实例进行了详细阐述,为快速确定合理加固区段提供合理的理论保证,并减少了试算和验算的工作量。     

橡胶沥青洒布车传热学分析及计算

根据热量平衡原理,阐述了橡胶沥青洒布车保温层厚度的设计计算过程,并按照洒布车施工时对介质加热升温的实际需要,探讨了两类沥青洒布车加热系统的特点,研究了外置导热油炉式加热系统的设计方法,指出通过沥青泵循环或增加机械搅拌装置来强化管外对流换热是提高换热速度的有效措施。     

国Ⅳ汽油车NEDC循环下的排放特性分析

对5辆满足国Ⅳ排放标准的不同汽油车进行了NEDC循环下的排放试验.结果表明,在机外净化方面,催化转化器具有较好的排放控制效果;在机内净化方面,缸内直喷式(CDI)汽油车HC和CO的排放小于进气管喷射式(PFI)汽油车,但NOx排放相对较高;两种喷油方式汽油车平均粒径小于1 um的颗粒物数量均超过了排放总量的95%;试验车在过渡工况占多数的市区运转循环下排放恶化,而在等速工况占多数的市郊运转循环下排放较好.