提高沥青-酸性集料抗水损害的试验研究

针对酸性集料与沥青粘附性差、混合料水敏感性大的难题 ,根据配位键理论采用含铬外加剂处理酸性集料 ,显著提高沥青与酸性集料的粘附性。用强化的冻融劈裂试验评价混合料水损害 ,对比试验说明经过含铬外加剂处理后的酸性集料混合料劈裂强度比提高显著 ,长期抗水损害性能也较好。     

汽车电动助力转向盘力特性的初步研究

从转向轴助力式电动转向系动力学模型出发,推导出转向盘力的仿真计算公式,并简要分析了比例控制式EPS系统的控制系数对其转向盘力特性的影响。得出通过采用可变比例控制的方式可以改善汽车的转向盘力特性的结论。     

高速公路中央分隔带槽形混凝土护栏的开发研究

简要介绍了高速公路中央分隔带槽形混凝土护栏的开发过程，提出了改进后的中央分隔带混凝土护栏的定型尺寸。研究结果表明，改进后护栏不仅造价降低，同时也改善了车辆碰撞的防护效果。     

内燃机振动动力式主动吸振器的研究

振动主动控制技术具有减振效率高，有效减振频率范围度，反应敏捷等优点，在机械振动领域具有广泛的应用前景。在一台四缸柴油机上进行振动主动控制的研究，使用主动控制技术控制动力吸振式的频率，使其能足够发动机的主动振动频率，并保持最佳状态，从而有效地抑制发动机的振动。     

Real-Time Fault Diagnosis for Gas Turbine Blade Based on Output-Hidden Feedback Elman Neural Network

In order to remotely monitor and maintain large-scale complex equipment in real time, China Telecom plans to create a total solution that integrates remote data collection, transmission, storage, analysis and prediction. This solution can provide manufacturers with proactive, systematic, integrated operation and maintenance service, and the data analysis and health forecasting are the most important part. This paper conducts health management for the turbine blades. Elman neural network, and improved Elman neural network, i.e., outputhidden feedback (OHF) Elman neural network are studied as the main research methods. The results verify the applicability of OHF Elman neural network.     

生存素在5-氟尿嘧啶诱导人绒癌细胞株JAR凋亡中的作用

目的探讨生存素(survivin)在化疗药物5-氟尿嘧啶(5-Fu)诱导的人绒癌细胞株(JAR)凋亡中的作用。方法用JAR细胞株进行培养传代,以不同浓度5-Fu作用于JAR细胞,MTT方法观察5-Fu对JAR细胞生长的抑制情况,流式细胞仪检测细胞凋亡率,用逆转录聚合酶链(RT-PCR)和免疫印迹技术(Western-blot)方法检测survivin基因和蛋白的表达。结果①5-Fu对JAR细胞的生长具有抑制作用,并有浓度和时间的依赖性;②5-Fu诱导JAR细胞凋亡,凋亡率随浓度而增加;③5-Fu作用后survivin基因和蛋白表达减少,随浓度增加而减少。结论5-Fu可能是通过降低survivin表达水平,诱导JAR细胞凋亡。     

Effect of ABCA1-V771M polymorphism on plasma lipid levels and its relationship with coronary atherosclerotic heart disease

Objective To explore the risk association of ABCA1-V771M polymorphism with coronary heart disease (CHD) in Hart nationality in Northwest of China. Methods With case-control study, ABCA1-V771M polymorphism was detected in 204 unrelated Hart nationality people in Northwest of China, and all the subjects by coronary angiography were grouped into 106 cases and 98 controls. The genotypes and alleles frequency distribution of ABCA1-V771M polymorphisms were analyzed by PCR-RFLP analysis, and the clinical statistics of serum lipids were compared and its effects of ABCA1-V771M polymorphism on the plasma lipid levels and coronary atherosclerotic heart disease were analyzed. Results The genotypic frequencies of ABCA1-V771M polymorphism matched well under Hardy-Weinberg equilibrium (P>0.05), V and M allelic frequencies were 33.3% and 66.7%. In comparison with VV VM genotype carriers, MM genotypes carriers had much lower plasma levels of HDL-C (P<0. 001) and much higher plasma levels of TG (P<0. 05). M allelic frequency in CHD group was significantly higher than V allelic frequency (P<0. 05). M allele was related with more severity of atherosclerosis in the coronary artery than V allele (P<0.05). However, there was no obvious difference in the incidence of AMI among carriers with three genotypes of ABCA1-V771M polymorphism (P>0.05). Conclusion ABCA1-V771M polymorphism was not only associated with the plasma levels of HDL-C and TG, but also related to the susceptibility and severity of coronary atheroselerotic heart disease. Moreover, M771 allele appeared to be atherogenie among Han population in Northwest of China.     

正常绒毛和葡萄胎中Mel-CAM标记中间型滋养细胞的增殖情况

目的探讨葡萄胎中Mel-CAM与滋养细胞黏附、浸润之间的关系以及Mel-CAM标记中间型滋养细胞(IT)的增殖情况。方法采用双重免疫组化法,检测Mel-CAM标记IT的Ki-67表达情况。结果葡萄胎中Mel-CAM表达较正常绒毛明显增高,差异有统计学意义(P<0.05);葡萄胎绒毛表面有Mel-CAM标记IT出现,而正常绒毛表面则无;葡萄胎组织中IT的Ki-67指数较正常绒毛明显增高,差异有统计学意义(P<0.05)。结论葡萄胎绒毛表面有Mel-CAM表达,表现出双重分化方向,这可能与葡萄胎的发病机制有关;检测葡萄胎组织中IT的Ki-67指数对于预测葡萄胎的转归有潜在的价值。     

基于旅游资源特色的公路护栏设计研究

文章总结了目前常用护栏形式的特点,讨论了各种护栏形式与不同类型的旅游资源之间的协调性.基于路段与旅游资源之间关系的分析,提出了旅游公路护栏设计的基本原则,并结合工程实例,讨论了各种形式护栏特殊设计的基本思路.     

政府介入能否有效推动技术创新:基于两个案例的分析

技术创新与产业升级是经济持续发展的核心动力,其成功与否攸关中国经济的未来.因此,约从2000年中期开始,国家便启动鼓励技术创新与产业结构升级的方针政策.然而,作者的田野调查发现,这类产业政策往往并未取得预期效果.作者通过对典型案例的深入分析,条理出政府介入创新失效的两种机制:“风险积聚”与“监督失灵”.前者是指国家介入促使企业不顾风险,从而提高了企业失败的可能性;后者是指创新活动无法衡量,导致政策实施过程中政府无法监督企业.在上述发现的基础上,作者进一步反思了政府介入在早期“追赶模仿”与如今“超前创新”两个不同发展阶段的作用效果,认为中国若想成功鼓励技术创新,必须转变既有的发展模式.