Study on T lymphocyte subsets and NK cells in patients with Graves＇ disease combined with type 2 diabetes

Objective To investigate changes in T lymphocyte subsets and NK cells in patients with simple Graves' disease (GD)and Graves' disease combined with type 2 diabetes mellitus (GD/T2DM). Methods Fifteen cases of GD/ T2DM were selected from our hospital from November 2001 to November 2004. Before and after therapy thyroid function, thyroglobulin antibody (TGA), thyroid microsomal antibody (TMA) and blood glucose level were measured, and T lymphocyte subsets (CD3, CD4, CD8, CD4/CD8) and NK cells (CD56) were measured by immunofluorescence double labeling monoclonal antibody and flow cytometry, respectively. At the same time, comparison was made with simple GD (15 cases), T2DM (15 cases) and healthy control (20 cases). Results Before therapy, CD4/CD8, CD4 and NK cells in GD/T2DM were less than normal, and there was no significant difference in comparison with simple GD (P<0.05). In T2DM group, only CD4/CD8 and CD4 were less than those of healthy controls (P<0.05). When thyroid function recovered after 1 to 3 months of methimazole treatment in both GD/T2DM and simple GD groups, various indexes recovered, which were more obvious in simple GD. Conclusion Immune hypofunction of GD may be the key to the immune abnormality of GD/T2DM, which is more significant than that of simple GD or T2DM. The recovery of thyroid function and immune abnormality is not consistent, and the recovery of GD is more significant than that of GD/T2DM.     

“工厂法”沉管隧道早期性能的足尺试验研究

由于沉管隧道管段体积大、结构形式复杂、施工工艺复杂,容易因温度、收缩以及约束等原因,造成管段结构在预制阶段出现危害性裂缝,进而影响结构的服役性能和耐久性能。文章依托在建港珠澳大桥沉管隧道工程实例,开展了足尺试验,对"工厂法"沉管管节关键部位的温度和应变发展实施了监测,分析对比了温度发展规律和应变发展规律。分析结果表明:在早期因混凝土水化热引起温度上升,整个管段结构膨胀受拉,温度到达峰值后逐渐下降,结构也收缩恢复;但由于混凝土自收缩等因素的存在,结构最终收缩受压。研究所提供的试验结果可作为深入进行数值分析的一个基础。     

FSAE赛车前悬架运动学仿真及参数优化

运用Catia软件建立某FSAE赛车前悬架三维模型,并将Catia中的坐标转换成Adams软件中的坐标,建立Adams前悬架模型。针对该FSAE赛车前悬架进行双轮跳动运动学仿真,并对悬架传递比和前轮定位参数进行参数优化。     

基于CFD的空气滤清器入口结构改进设计

采用基于时均Navier-Stokes方程和高雷诺数k-ε紊流模型,对某一型号空气滤清器入口部分进行了流动计算,并根据计算结果对压力、速度特性进行了分析,提出了改进模型。通过对改进后模型的计算,可以看出内部流场和流速的分布都得到了改善,证明改进后的结构更符合气体流动特性。     

临近地铁的燃气设备振动特性及隔振措施分析

对燃气设备自身运行的振动特征及临近的地铁线路列车经过后叠加的振动响应特性进行了现场测试,分析了地铁线路对临近的燃气设备的振动影响特征.以某地铁线路下穿燃气调压站实际工程为案例,对燃气设备应对地铁列车振动的控制措施及其效果进行了研究分析.研究结果表明:地铁列车通过时,周边燃气设备的振动速度幅值增加明显、加速度幅值变化较小...     

高职院校新能源汽车技术教学内容与方法探讨

如今汽车行业发展十分迅速,新能源汽车已经成为了汽车行业的重要组成部分,为了更好培养新能源汽车产业市场高技能人才,有很多高职院校相继开设了新能源汽车技术专业或汽车检修专业新能源方向。在开设这些课程的时候,教师一定要实现与时俱进的发展目标,注重对学生综合素质的提升,文章将会针对高职新能源汽车技术教学内容与方法等内容进行简要论述和分析,希望能够为人们带来一些帮助和启发。     

桥墩拼装工法用新型预应力锚固体系的开发与应用

当前我国桥墩预制拼装工法应用越来越多,通过分析桥墩预制拼装工法中各种常用竖向预应力锚固体系的优缺点,提出了一种新型的、具有自锁功能的竖向预应力锚固体系。主要从该预应力锚固体系的研究背景、结构设计、试验研究、施工工艺研究和工程应用等方面进行阐述。研究和应用表明该新型预应力锚固体系锚固性能可靠、施工工艺简单、质量易保证、成本较低,能很好满足预制构件竖向拼装的需要,值得在工程中推广应用。     

青岛胶州湾海底公路隧道通风方案设计

青岛胶州湾隧道为特长海底隧道,属城市快速交通隧道,其通风设计是隧道建设中的关键环节.参照国内、外既有隧道的有关资料,结合本隧道的具体特点进行了多个通风方案比选,认为采用分段纵向通风加洞口高排方案最为经济合理;通过对隧道风量计算等问题进行的深入研究,提出了采用"在用机动车综合排放因子"的计算方法.     

Response-based analysis for Tension Leg Platform

The typical industry practice for Tension Leg Platform (TLP) design focuses on a conventional short-term design recipe, which assumes that an N-year design environment leads to an N-year response. In the response-based design method, the TLP is designed to withstand N-year responses rather than respond to N-year environmental conditions. In this paper, we present an overview and a general procedure for the response-based design method and use a case study to compare the critical TLP responses between the two methods. The results of our comparison show that the conventional short-term design method often contains an element of conservatism and that the response-based design method can reduce the design conditions and thereby achieve cost savings.     

隧道下穿超浅埋国道的爆破减振技术

隧道下穿交通量大、超浅埋的国道公路时,为了能安全穿越,确保行车畅通,围岩开挖采用了拱上部周边打空炮眼减振、开挖面增打减振孔、炮孔复合装药、预留光爆层等综合减振措施的爆破技术。经现场爆破监测,爆破振动波速基本控制在20mm/s之内,降低了爆破的振波,有效地控制了公路地表下沉,确保了公路运营的安全。