高氧液在新生儿缺血缺氧性疾病中的应用

目的　探讨高氧液对新生儿缺血缺氧性疾病治疗的可行性及疗效。方法　采用比色法、血气分析检测 2 0例用高氧液患儿血浆SOD、MDA及血气变化 ,同时以 2 0例未用高氧液患儿作对照 ,观察临床症状、体征改变。结果　用高氧液组PaO2 、SaO2 明显升高 (P <0 .0 1) ,PaCO2 明显下降 (P <0 .0 1) ,同时有pH、HCO3 -、BE下降 ;血浆SOD升高、MDA下降 (P <0 .0 1) ;用高氧液临床症状体征迅速改善 ,有效率 95 % (P <0 .0 5 )。结论　高氧液对治疗新生儿缺血缺氧性疾病尤其是低氧血症有明显效果     

人行通道工程梯道明挖支护方案的设计

介绍了某剧院地下人行通道梯道明挖段施工的基本情况,论述了如何在不破坏原有建筑和地下管线的前提下,将梯道支护结构方案进行合理变更,并阐述了梯道明挖的施工方法。     

罗红霉素胶囊在人体的药代动力学及生物等效性

目的建立人血浆中罗红霉素浓度的高效液相分析方法,用于研究罗红霉素胶囊在人体的药代动力学和生物等效性。方法血浆样品采用己烷-异戊醇(98∶2)液-液萃取,反相高效液相法测定。结果罗红霉素的线性范围为0.25-32.06 mg/L(r为0.999 2),最低检出质量浓度为0.25 mg/L,最低检出量为12.5 ng,提取回收率为68.0%-72.8%,方法回收率为90.7%-99.4%。单次服用300 mg罗红霉素胶囊受试制剂或参比制剂后的药动学参数AUC0-48h、Cmaxt、maxt、1/2分别为(101.84±27.69)(mg.h)/L和(103.5±30.83)(mg.h)/L,(8.54±1.95)mg/L和(8.07±1.81)mg/L,(1.6±0.6)h和(1.8±0.6)h,(10.4±2.9)h和(10.5±2.6)h。受试制剂相对生物利用度为(100.5±19.1)%。结论该方法专一性较好,血浆内源性杂质无干扰,结果准确。罗红霉素的两种制剂间主要药动学参数无明显差异,具有生物等效性。     

基于GIS的机场道面管理系统

总结国内外建立机场道面管理系统的先进经验，根据机场道面管理和GIS的特点，构建了机场道面管理系统的基本结构和机场的分区管理模式，研究了建立机场道面的空间数据库和属性数据库的方法及其管理方法，介绍了系统关于GIS的主要功能。实践证明该方法符合实际．对建立基于GIS的机场道面管理系统是可行的。     

大跨度拱桥减震分析

以西藏尼木大桥为研究对象,结合该桥型特点,采用大型通用软件对其进行了模态分析和动力计算.通过模拟地震响应得到该桥的反应特性,由此采用调谐质量控制器(TMD)对该桥进行受控分析.采用振型贡献率确定受控模态,在获取TMD系统的优化参数后将其模拟入有限元模型中,并最终通过时程分析验证了TMD运用于拱桥被动减震控制的有效性.     

东菱精纯克栓酶对急性脑梗塞溶栓治疗的疗效观察

用东菱精纯克栓酶（DF-521）对116例急性脑梗塞进行了前瞻性、随机、开放对照治疗研究。并设对照组（常规治疗方法）108例。结果显示：克检酶治疗组总有效率为9741％，疗效明显优于对照组73．15％，并且有作用快，病程短，功能恢复好，不良反应少的优点，是治疗脑梗塞值得推广的药物。     

SD模型在我国汽车租赁行业发展趋势分析中的应用

从我国汽车租赁业发展现状入手，通过大量统计数据分析了汽车租赁行业特点，从市场和法规两方面提出了影响该行业发展的诸多因素，建立了相应的SD模型，其中包括进行系统因果分析、流图设计和模型构造．通过模型模拟来定量分析我国汽车租赁业发展趋势．     

基于CFD技术的砰击载荷强度直接计算

研究基于CFD技术的船舶砰击载荷预报及强度的直接计算,以通过对船波相对运动的短期预报得到入水速度极值,由积分变换得到入水速度的时历曲线,以CFD软件实现船体典型剖面入水砰击载荷的计算,得到船体剖面压力的空间分布,结果表明,船体剖面的压力随着位置高度的增加呈减小趋势,最后通过对某集装箱船进行有限元强度评估,验证了本文砰击强度直接计算方法的合理性和实用性。     

Severity of pedestrian injuries due to traffic crashes at signalized intersections in Hong Kong: a Bayesian spatial logit model

The present study intended to (1) investigate the injury risk of pedestrian casualties involved in traffic crashes at signalized intersections in Hong Kong; (2) determine the effect of pedestrian volumes on the severity levels of pedestrian injuries; and (3) explore the role of spatial correlation in econometric crash‐severity models. The data from 1889 pedestrian‐related crashes at 318 signalized intersections between 2008 and 2012 were elaborately collected from the Traffic Accident Database System maintained by the Hong Kong Transport Department. To account for the cross‐intersection heterogeneity, a Bayesian hierarchical logit model with uncorrelated and spatially correlated random effects was developed. An intrinsic conditional autoregressive prior was specified for the spatial correlation term. Results revealed that (1) signalized intersections with greater pedestrian volumes generally exhibited a lower injury risk; (2) ignoring the spatial correlation potentially results in reduced model goodness‐of‐fit, an underestimation of variability and standard error of parameter estimates, as well as inconsistent, biased, and erroneous inference; (3) special attention should be paid to the following factors, which led to a significantly higher probability of pedestrians being killed or sustaining severe injury: pedestrian age greater than 65 years, casualties with head injuries, crashes that occurred on footpaths that were not obstructed/overcrowded, heedless or inattentive crossing, crashes on the two‐way carriageway, and those that occurred near tram or light‐rail transit stops. Copyright © 2017 John Wiley & Sons, Ltd.     

Numerical analysis of the dynamic interaction between wheel set and turnout crossing using the explicit finite element method

A three-dimensional (3-D) explicit dynamic finite element (FE) model is developed to simulate the impact of the wheel on the crossing nose. The model consists of a wheel set moving over the turnout crossing. Realistic wheel, wing rail and crossing geometries have been used in the model. Using this model the dynamic responses of the system such as the contact forces between the wheel and the crossing, crossing nose displacements and accelerations, stresses in rail material as well as in sleepers and ballast can be obtained. Detailed analysis of the wheel set and crossing interaction using the local contact stress state in the rail is possible as well, which provides a good basis for prediction of the long-term behaviour of the crossing (fatigue analysis). In order to tune and validate the FE model field measurements conducted on several turnouts in the railway network in the Netherlands are used here. The parametric study including variations of the crossing nose geometries performed here demonstrates the capabilities of the developed model. The results of the validation and parametric study are presented and discussed.