陕南燃煤型砷中毒患者内外环境砷、硒水平及对血清P53、BCL-2、NO、MDA的影响

目的探讨陕南燃煤型砷中毒患者内外环境砷、硒水平及对血清P53、B淋巴细胞瘤/白血病-2(BCL-2)、一氧化氮(NO)、丙二醛(MDA)的影响。方法采用石墨炉原子吸收法测定煤、水、土、玉米、辣椒、血清、尿、发中砷、硒含量;采用ELISA法、硝酸还原酶法、TBA法分别测定血清P53、BCL-2、NO、MDA水平。结果病区煤、土、玉米、辣椒中砷、硒含量显著高于非病区;病例组血清、尿和发砷、硒含量显著高于内、外对照组;病例组血清BCL-2水平显著高于外对照组,病例组、内对照组的血清MDA水平显著低于外对照组。结论陕南燃煤型砷中毒患者内、外环境砷含量增高,外环境硒含量偏高而内环境硒负荷适宜,其血清BCL-2水平增高,MDA降低,而P53、NO无显著变化。     

西安市城区绝经后妇女骨密度与女性生理因素的相关性

目的探讨绝经后妇女女性生理因素与腰椎、髋部骨密度的关系。方法对西安市城区281名绝经后妇女进行了女性生理因素的流行病学调查,并测定了腰椎、髋部骨密度。结果相关分析显示年龄、绝经年限、生育活产子女数和骨密度均呈显著负相关(P<0.01),而行经年限、身高、体重及体重指数(BMI)和骨密度均呈显著正相关(P<0.01)。比较骨质疏松组、骨量减少组和骨量正常组,年龄、绝经年限、生育活产子女数等,骨质疏松组明显高于骨量减少组和正常组(P<0.05);而平均每次月经持续天数、行经年限、身高、体重、BMI等,骨质疏松组明显低于骨量减少组和正常组(P<0.05)。结论西安市城区绝经后妇女的年龄、行经年限、绝经年限、生育活产子女数、身高、体重和BMI等与其腰椎和髋部的骨密度有明显的相关性。     

金、银湖内渍水位计算与分析

武汉市金山公路沿线经过金、银湖内涝区,该地区的内渍设计水位直接控制该项目路基和桥梁的设计标高.本文简要介绍湖区内渍设计水位的三种计算方法,按照"一法为主、多法比较、合理选用"的原则,选取较为合理的计算结果作为设计的依据.     

水泥土搅拌桩挡墙在基坑支护中的应用

分析了水泥土搅拌桩挡墙的设计和施工,将其作为一种基坑支护方案的优点是造价低、工期短、隔水性好等,可供相关工程参考.     

大跨钢管混凝土拱桥实测与理论温差变形分析

介绍了合阳嘉陵江大桥钢管混凝土拱桥变形观测方法,分析了该桥实测变形及理论温差计算变形之间差异及造成差异的原因,并指出运营多年大跨径钢管混凝土拱桥变形复杂的空间状态,其变形状态往往是不可准确预测。     

Research on Multi-Objective Real-Time Optimization of Automatic Train Operation (ATO) in Urban Rail Transit

The determination and optimization of Automatic Train Operation (ATO) control strategy is one of the most critical technologies for urban rail train operation. The practical ATO optimal control strategy must consider many goals of the train operation, such as safety, accuracy, comfort, energy saving and so on. This paper designs a set of efficient and universal multi-objective control strategy. Firstly, based on the analysis of urban rail transit and its operating environment, the multi-objective optimization model considering all the indexes of train operation is established by using multi-objective optimization theory. Secondly, Non-dominated Sorting Genetic Algorithm II (NSGA-II) is used to solve the model, and the optimal speed curve of train running is generated. Finally, the intelligent controller is designed by the combination of fuzzy controller algorithm and the predictive control algorithm, which can control and optimize the train operation in real time. Then the robustness of the control system can ensure and the requirements for multi-objective in train operation can be satisfied.     

基于柔性车架的摩托车虚拟样机建模及仿真

在基于虚拟样机技术的摩托车多体动力学模型构建中导入有限元柔性车架,建立了更为真实的整车虚拟动力学模型;对刚性、柔性2种车架模型路面载荷谱输入的振动仿真结果进行对比表析,柔性车架的整车虚拟样机模型更符合实际情况。     

大跨度钢管混凝土拱桥时域抖振分析

探讨了利用非平稳随机过程理论和少量的实际风速记录模拟自然风,并以此作为桥址处的自然风用时域抖振分析方法对某系杆拱桥进行抖振时域分析。通过将计算结果与风洞试验结果的比较,发现二者误差不大。     

EFFECT OF LOW SELENIUM ON CHONDROCYTE DIFFERENTIATION AND DIFFERENTIAL EXPRESSION OF COLLAGEN TYPES Ⅰ , Ⅱ AND X IN ARTICULAR CARTILAGE FROM MINI-PIGS

Objective According to the distribution of low selenium areas, low nutrition state of the residents and the affecting cartilage growth and articular cartilage of Kashin-Beck Disease(KBD),the chondrocyte differentia- tion and differential expression of collagen types Ⅰ , Ⅱ and Ⅹ in articular cartilage from Chinese mini-pigs treated with low selenium were investigated in order to gain insight into the effects of these conditions on chondrocyte differ- entiation in KBD cartilage. Mothods Eleven male juvenile mini-pigs, aged from 4 weeks to 6 weeks after birth, were divided into 3 groups. The Se content in the diet of the “low Se” group was 0. 035mg/kg diet, and 0. 175 mg/kg diet in the control. For Se-supplemented group 0. 390mg /kg diet was added. The content of Se in blood was assayed at the beginning and at the end of each experiment. Samples of articular cartilage were taken from the right femur condylus, and collagen types Ⅰ , Ⅱ and Ⅹ in articular cartilage were analyzed by immunohistochemistry and in situ hybridization. Results ①All cartilage samples from juvenile mini-pigs fed with low selenium diet revealed a re- duction in type Ⅹ collagen mRNA expression in the hypertrophic chondrocytes as shown by in situ hybridization, and reduced type Ⅹ collagen deposition in the lower hypertrophic zone as shown by immunohistochemistry. ②Addition of selenium to the diet restored the type Ⅹ collagen to normal level. ③Type Ⅱ collagen was evenly distributed over the entire articular cartilage in all experimental and control groups. Type Ⅱ collagen mRNA signals were most prominent in the upper articular layer as well as in the hypertrophic zone in all groups. Type Ⅱ collagen expression was restrict- ed to the zone of endochondral ossification in all experimental groups and the control. Conclusion Low selenium has an down-regulatory role on the synthesis and deposition of collagen type Ⅹ in hypertrophic chondrocytes in articular cartilage of mini-pigs. Supplement of the low Se diet with additional Se restored the signals of collagen type Ⅹ to nor- mal levels. These findings indicate that selenium deficiency may disturb chondrocyte differentiation to hypertrophic cells in the growth plate,and worthy to be investigated further.     

A SPEECH RECOGNITION METHOD USING COMPETITIVE AND SELECTIVE LEARNING NEURAL NETWORKS

IntroductionHMM method and neural networks as a feasiblemethod have been used in speech recognitionsystem for several years,many improved meth-ods are still being discussed and proposed to en-hance its performance.On the basis of tradition-al HMM method and selection mechanism ,anew CSL algorithm ( competitive and selectivelearning neural networks) is proposed in this pa-per,which enables the system to avoid localminimum and have high recognition rate usingwith HMM and PSHNN.Isodistortio…