贺斯行急性超容性血液稀释时对机体血液动力学及凝血功能的影响

目的　观察羟乙基淀粉 (6 %贺斯 2 0 0 0 .5 ,HES)行急性超容性血液稀释 (AHHD)时血液动力学、血气及凝血功能的变化。方法　选择ASAⅠ -Ⅱ级在硬外复合浅全麻下行食道癌根治及全髋置换手术患者 5 0例 ,麻醉前 30～4 0min内输入HES(15mL·kg- 1 ) ,使血容量增加 2 0 %。当Hb低于 90 g·L- 1 时输入同型异体血。术中连续监测HR、BP、SpO2 ,于HD前 (H0 )、HD后 15min(H1 )、输入同型异体血前 (H2 )以及术毕 (H3)各时点抽取动、静脉血行血气分析、血常规及凝血功能检测。结果　HR、BP在整个手术过程中无明显变化 (P >0 .0 5 ) ;Hb、Hct在HD后各时点均降低 (P <0 .0 5或P <0 .0 1)。PT在HD后H1 、H2 ,FIB在H2 时均明显降低 (P <0 .0 5或P <0 .0 1)。结论　采用HES行AHHD对心、肺、肝、肾及凝血功能正常患者行血液保护是安全有效的 ,可避免异体血不必要的输入     

A hybrid firefly algorithm for optimizing fractional proportional-integral-derivative controller in ship steering

In this paper, a new algorithm which integrates the powerful firefly algorithm(FA) and the ant colony optimization(ACO) has been used in tracking control of ship steering for optimization of fractional-order proportional-integral-derivative(FOPID) controller gains. Particle swarm optimization(PSO) algorithm is also used to optimize FOPID controllers, and their performances are compared. It is found that FA optimized FOPID controller gives better performance than others. Sensitivity analysis has been carried out to see the robustness of optimum FOPID gains obtained at nominal conditions to wide changes in system parameters, and the optimum FOPID gains need not be reset for wide changes in system parameters.     

三种路面破损分类算法的仿真比较

路面破损分类是制约路面破损自动检测的发展和普及的重要因素之一。本文在前文提出的破损密度方法的基础上,提炼出两种基于密度因子方法的算法——基本密度因子算法和方向密度因子算法,并通过仿真,验证了其对常见的5种路面破损类型进行分类的可行性。文中作为对照的方法是由美国Lee,Byoung Jik博士提供的PROXIMITY算法。仿真结果表明：1)三种路面破损分类算法中,方向密度因子算法对5种常见路面破损类型的整体识别效果最好;2)对于常规算法最难区分的块状裂缝和龟状裂缝,基本密度因子的算法的识别效果最好。这充分验证了前文中我们提出的基于破损密度因子的路面破损分类方法的可行性和优越性。     

TSH RECEPTOR GENETIC ALTERATIONS IN THE AUTONOMOUSLYFUNCTIONING THYROID ADENOMAS

Objective To determine the relationship between TSH receptor gene mutations and autonomously functioning thyroid adenomas (AY‘]rAs). Methods The thyroid samples from 14 cases of diagnosed AFTAs were analyzed, with normal thyroid specimens adjacent to the tumors as controls. The 155 base pairs DNA fragments which encompassed the third cytoplasmic loop and the sixth transmembrane segments in the TSH receptor gene exon 10 were amplified by Polymerase chain reaction (PCR) and analyzed by the single-strand conformation polymorphism (SSCP). Direct sequencing of the PCR products was performed with Prism Dye Terminator Cycle Sequencing Core Kit.Results 6 of 14 AFTA specimens displayed abnormal migration in SSCP analysis. In sequence analysis of 3 abnormally migrated samples, one base substitution at nucleotide 1957 (A to C) and two same insertion mutations of one adenosine nucleotide between nucleotide 1972 and 1973 were identified. No mutations were found in controls. Conclusion This study confirmed the presence of TSH receptor gene mutations in AFTAs; both one-point substitution mutation and onebase insertion mutation were found to be responsible for the pathogenesis of AFTAs.     

PROLIFERATION AND MIGRATION OF EPENDYMAL CELLS IN THE BRAIN OF ADULT RATS AFTER PERMANENT FOCAL CEREBRAL ISCHEMIA

Objective Ependymal cells are thought to be the primary source of neural stem cells in the adult central nervous system. The purpose of this study is to examine spatial and temporal profiles of ependymal cell proliferation and migration after focal cerebral ischemia. Methods Eighty male Sprague Dawley rats underwent permanent middle cerebral artery occlusion after injection of 10/μL of 0.2% Dil into the lateral ventricle. Rats were sacrificed and brain sections were acquired for pathological evaluation and laser confocal imaging at day 1,3,7,11,14,21 and 28 after ischemia. Results The density of Dil-labeled cells in the ischemic ipsilateral subventricular zone was significantly higher than that in the control group and these labeled cells dispersed in the ischemic ipsilateral subventricular zone and/or were located in ependyma from day 1 to 11. In the ischemic ipsilateral cortex, some Diilabeled cells occurred in peri-infarction and infarction of parietal region at day14 and peaked at day 21 when some Dil-labeled cell nodules were found in this region. During postischemic day 14--28, a significant decrease in labeled celldensity in the ischemic ipsilateral subventricular zone was coincident with a significant increase in labeled cells density in the cortex (peri-infarction and infarction). Conclusion The results indicate that ependymal cells proliferate and migrate after focal cerebral ischemia in the adult rat brain.     

EFFECTS OF FILTER MEMBRANES ADSORBING INFLAMMATORY MEDIATORS IN HEMOFILTRATION

Sepsisischaracterizedbyreleaseofexcessiveamountofproinflammatorycytokinesinthecircu lation ,leadingtoa generalizedanduncontrolledhostresponse .Aconsiderablenumberofexperimen talandclinicalinvestigatorshavereportedemploy inghemofiltration (HF)toeliminatecytokinesandchemokines .Thisexcessiveinflammatoryresponsecouldbedownregulatedwithremovalofcytokinesandothermediators .Thesedatashowedthatthemechanismofmediatorseliminationwaslinkedtoconvectionandadsorptionbyhemofiltration .Ad sorptionappearstob…     

经颈静脉肝内门体分流术治疗肝硬化门脉高压症对机体液递物质的影响及疗效

目的探讨经颈静脉肝内门体分流术(TIPS)治疗肝硬化门脉高压症对机体液递物质的影响及其临床疗效评价。方法肝硬化门脉高压症患者40例,分为TIPS组和内科组,每组20例。另选健康成人20例,作为正常对照组。应用放免法及生化分析法测定各组各时段血清一氧化氮(NO)、白细胞介素-6(IL-6)及血浆丙二醛(MDA)的水平,观察临床表现及肝功能的变化。结果TIPS术后所有患者出血停止,一般状况改善明显,TIPS术后1 d血清丙氨酸氨基转移酶(ALT)较术前升高,且差异有显著性(P<0.01),术后7 d有所降低,与术前相比无显著性差异。两治疗组40例患者血清NOI、L-6及血浆MDA水平治疗前后均高于健康正常人(P<0.01)。TIPS组术后NO水平与内科组治疗一周后相比明显升高(P<0.01)。TIPS组术后NO水平较术前明显升高(P<0.01)。结论TIPS治疗肝硬化门静脉高压症近期疗效显著,术后肝功能无明显损害;术后血清NO水平升高,其机制可能与TIPS引起门脉及全身血流动力学变化有关;MDA无明显变化,表明肝脏总的血流灌注减少不明显。     

基于神经网络的高温下（后）预应力损失分析

提出了基于神经网络的高温下(后)预应力损失的评价方法.针对影响高温下(后)预应力损失的复杂多变性和相当强的不确定性,建立了基于神经网络的高温下(后)预应力损失模型.运用神经网络强大的自适应、自组织、自学习的能力以及高度的非线性映射性、泛化性和容错性的特点,通过对训练样本的神经网络学习,建立了预应力损失与温度、初始有效预应力以及高温条件的网络关系,最终实现了对测试样本的预应力损失预报.     

连续配筋混凝土加铺层研究

介绍了旧水泥混凝土路面上连续配筋混凝土加铺层的结构型式、端部锚固结构以及施工技术,以为连续配筋混凝土路面在旧水泥混凝土路面加铺中的应用提供参考。     

工程项目成本管理与控制

结合工程实例介绍了工程项目管理的具体内容和成本控制的具体措施。