Interaction between fragile histamine triad and protein kinase C alpha in human non-small cell lung cancer tissues

Objective To investigate the interaction between fragile histamine triad (FHIT) and protein kinase C alpha (PKCα) in human non-small cell lung cancer tissues. Methods FHIT and PKC伪 double positive samples were screened by immunohistochemical staining from 13 human non-small cell lung cancer tissues. Co-immunoprecipitation was performed by using anti-FHIT and anti-PKCα. The immune precipitate was analyzed by SDS-PAGE and Western blot. Results Immune precipitate staining detection showed that 3 samples out of the 13 cases were double positive for FHIT and PKCα. FHIT protein was present in the immune precipitate of anti-PKCα while there was PKCα in the immune precipitate of anti-FHITmAb. Conclusion FHIT and PKCα exist as a complex in human non-small cell lung cancer tissues, which will provide a new route for studying the pathogenesis and immunotherapy of human non-small cell lung cancer.     

项目现场安全管理资料的收集和整理

安全管理资料的收集与管理,是施工现场安全生产的基础性工作,也是检查落实安全生产责任制的依据。做好这项工作,对于保证工程项目的安全和质量具有十分重要的意义。     

加装颗粒物捕集器的城市公交车辆加载减速烟度和功率实验研究

为了验证柴油车颗粒物捕集器在公交车辆上的使用性能,采用柴油车加载减速工况法,分别测试了安装柴油车颗粒物捕集器前、后车辆的烟度和功率,分析了安装不同颗粒物捕集器后车辆烟度和功率产生变化的原因.分析结果表明:车辆安装同一过滤载体而不同再生方式的颗粒物捕集器后,随着行驶里程的增大,柴油机烟度降低率和功率都有所下降,烟度过滤效率取决于车辆技术状况和颗粒物捕集器的过滤性能;安装被动催化类捕集器的车辆功率受排气温度和催化剂影响较大,而安装主动再生类捕集器的车辆功率受再生效果影响较大.     

高速公路运营成本及其控制

成本管理及控制是实现高速公路效益目标的主要决定因素。因此,加强高速公路运营的成本管理,降低成本消耗,对提高高速公路的整体营运效益极为重要。     

道路用煤矸石研究

煤矸石的堆放不仅占用土地、污染环境、浪费资源、破坏生态,煤矸石还会爆炸伤人,可能引发泥石流、滑坡等地质灾害.通过研究煤矸石的物理化学性质,发现其所舍有的矿物质有利于用作筑路材料.因此,积极发展煤矸石在道路工程中的综合利用,变废物为资源,是节约能源、节约土地、保护环境、发展循环经济、建设节约型社会的重大举措.     

Numerical simulation of rock fracturing under uniaxial compression using virtual internal bond model

A multi-scale virtual internal bond (VIB) model for the isotropic materials has been recently proposed to describe the material deformation and fracturing. During the simulation process of material fracturing using VIB, the fracture criterion is directly built into the constitutive formulation of the material using the cohesive force law. Enlightened by the similarity of the damage constitutive model of rock under uniaxial compression and the cohesive force law of VIB, a VIB density function of rock under uniaxial compression is suggested. The elastic modulus tensor is formulated on the basis of the density function. Thus the complete deformation process of rock under the uniaxial compression is simulated.     

混沌映射在彩色图像水印中的应用

提出了一种新的基于混沌理论的彩色图像水印方法.在空域中RGB色彩空间的蓝色信道里嵌入水印以提高水印隐性和鲁棒性.水印的检测同样只在蓝色信道里进行,通过相关性的比较来确定结果.实验结果表明,文中所提出的水印方法速度快、易于实现,具有较高的安全性,并对包括剪裁在内的几何攻击有很好的鲁棒性.     

端羟基聚乳酸低聚物的合成研究

以1,4丁二醇为功能单体,将乳酸预脱水、减压聚合成功制备了不同分子量的端羟基聚乳酸低聚物。考察了聚合压力、1,4丁二醇与催化剂用量等不同条件对端羟基聚乳酸低聚物分子量的影响。研究表明随1,4丁二醇用量的增大,所得低聚物分子量逐渐降低;降低聚合压力能提高低聚物分子量;加大催化剂SnCl2.2H2O的用量能较小程度地增加低聚物分子量的分子量,但SnCl2.2H2O的用量以0.5%为宜。     

DC gain analysis of scaled CMOS op amp in Sub-100 nm technology nodes: A research based on channel length modulation effect

Metal-oxide-semiconductor field effect transistor (MOSFET) intrinsic gain degradation caused by channel length modulation (CLM) effect is examined. A simplified model based on Berkeley short-channel insulator-gate field effect transistor model version 4 (BSIM4) current expression for sub-100 nm MOSFET intrinsic gain is deduced, which only needs a few technology parameters. With this transistor intrinsic gain model, complementary metal-oxide-semiconductor (CMOS) operational amplifier (op amp) DC gain could be predicted. A two-stage folded cascode op amp is used as an example in this work. Non-minimum length device is used to improve the op amp DC gain. An improvement of 20 dB is proved when using doubled channel length design. Optimizing transistor bias condition and using advanced technology with thinner gate dielectric thickness and shallower source/drain junction depth can also increase the op amp DC gain. After these, a full op amp DC gain scaling roadmap is proposed, from 130 nm technology node to 32 nm technology node. Five scaled op amps are built and their DC gains in simulation roll down from 69.6 to 41.1 dB. Simulation shows transistors biased at higher source-drain voltage will have more impact on the op amp DC gain scaling over technology. The prediction based on our simplified gain model agrees with SPICE simulation results.     

阜阳公交便民“触角”30年延伸30倍

改革开放初期,阜阳市仅有17台公交营运车辆,公交线路仅有2条,线路总长不足13公里。到目前,阜阳市公交总公司拥有营运车辆516台,运营线路22条,线路总长达到了386公里。改革开放30年,阜阳公交线路由13公里发展到386公里,公交营运便民“触角”延伸了30倍。